Persistent attentional dysfunction in remitted bipolar disorder

Wilder-Willis, Kelly E.; Sax, Kenji W.; Rosenberg, Hannah; Fleck, David E.; Shear, Paula K.; Strakowski, Stephen M.

doi:10.1034/j.1399-5618.2001.030202.x

Cited by 131 publications

(83 citation statements)

References 22 publications

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“…Findings in this research area indicate that euthymic patients commonly exhibit deficits on various measures derived from a range of sustained attention tasks (13,20,21,(23)(24)(25)(26); however, these impairments are not universal (11,27). As with the examination of executive deficits, it is possible that discrepant findings are at least partly due to different tests or measures that are employed across studies.…”

Section: Considerationsmentioning

confidence: 98%

“…Additionally, although more studies are needed in bipolar patients, the favourable cognitive profile of atypical antipsychotic agents is recognized in psychotic disorders such as schizophrenia and implied in bipolar disorder (60). The absence of association between medication dose and cognitive impairment in most studies of euthymic bipolar patients suggests that if medication side effects are present, they are relatively minor in magnitude and do not probably account for the full extent of cognitive impairment in euthymic bipolar disorder (6,9,13,14,16,18,20,24,26,30). Another potential confound that has received some attention is the influence of residual or subclinical mood symptoms on neurocognitive functioning in euthymic patients.…”

Section: Potential Confounds or Moderatorsmentioning

confidence: 99%

See 1 more Smart Citation

Neuropsychological functioning in euthymic bipolar disorder: a meta‐analysis

Torres

Boudreau

Yatham

2007

Acta Psychiatr Scand

535

370

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IntroductionIt is well established that patients with bipolar disorder in acute manic-depressive states show considerable cognitive impairment (1-3). In recent years, however, there has been a strong shift towards studying neurocognitive functions in euthymic patients with bipolar disorder. These Torres IJ, Boudreau VG, Yatham LN. Neuropsychological functioning in euthymic bipolar disorder: a meta-analysis.Objective: Although cognitive deficits are prominent in symptomatic patients with bipolar disorder, the extent and pattern of cognitive impairment in euthymic patients remain uncertain. Method: Neuropsychological studies comparing euthymic bipolar patients and healthy controls were evaluated. Across studies, effect sizes reflecting patient-control differences in task performance were computed for the 15 most frequently studied cognitive measures in the literature. Results: Across the broad cognitive domains of attention ⁄ processing speed, episodic memory, and executive functioning, medium-to-large performance effect size differences were consistently observed between patients and controls, favoring the latter. Deficits were not observed on measures of vocabulary and premorbid IQ. Conclusion: Meta-analytic findings provide evidence of a trait-related neuropsychological deficit in bipolar disorder involving attention ⁄ processing speed, memory, and executive function. Findings are discussed with regard to potential moderators, etiologic considerations, limitations, and future directions in neuropsychological research on bipolar disorder.

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Section: Considerationsmentioning

confidence: 98%

Section: Potential Confounds or Moderatorsmentioning

confidence: 99%

Neuropsychological functioning in euthymic bipolar disorder: a meta‐analysis

Torres

Boudreau

Yatham

2007

Acta Psychiatr Scand

535

370

View full text Add to dashboard Cite

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“…However, the NCI, with medians of 72.0, 73.5 and 67.5 for each [25][26][27][28][29][30][31][32][33][34][35] different types. In unipolar depression, impairment when present affected attention and concentration, learning, and in some cases, executive function 23 .…”

Section: Discussionmentioning

confidence: 99%

Funciones cognitivas y terapia electroconvulsiva en pacientes psiquiátricos con enfermedad afectiva

Constaín

Saldarriaga

Rodríguez-Gásquez

et al. 2018

MedUPB

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Funciones cognitivas y terapia electroconvulsiva en pacientes psiquiátricos con enfermedad afectiva / Funções cognitivas e terapia eletroconvulsiva em pacientes psiquiátricos com doenças afetiva Gustavo A. Constaín 1 , María Victoria Ocampo Saldarriaga 2 , María de los Ángeles Rodrí-guez-Gásquez 3 , Julio César Restrepo Zapata 4 , David Monroy Duque 5 ABSTRACT Objective: Electroconvulsive therapy (ECT) has been considered a safe and effective treatment for depression, manic episodes, and other serious psychiatric conditions. Its main reported side effect has been cognitive impairment. This study describes the cognitive effects of ECT in psychiatric patients referred for treatment at a private clinic. Methodology: Descriptive case series study. A baseline assessment conducted before starting ECT, and another two (at one week and at six months) after completing the treatment cycle were used to describe the effects of frontotemporal bilateral ECT on neurocognitive function in terms of the change from the baseline to the final assessment in the domains of memory, psychomotor speed, reaction time, complex attention, and cognitive flexibility, as well as global cognitive function, as well as to determine ECT's safety by reporting adverse events. Cognitive assessment was conducted with a neuropsychological test battery and severity of psychiatric illness with the Clinical Global Impression-Severity scale (CGI-S). Six patients referred for treatment during six months were included. Results: No statistically significant differences were observed between the medians of the evaluations of CGI-S scale, global cognitive function or any of the domains evaluated. Conclusions: ECT did not produce changes in the cognitive functions assessed in the six studied patients. Keywords: electroconvulsive therapy; cognitive functions; adverse events; neuropsychological evaluation. RESUMENObjetivo: la terapia electroconvulsiva (TEC) se ha considerado un tratamiento seguro y eficaz para episodios de depresión mayor, para episodios maníacos y otros trastornos psiquiátricos serios. El estudio describe los efectos cognitivos de la TEC en pacientes referidos para tratamiento a una clínica privada. Metodología: estudio descriptivo del tipo de serie de casos. En cada participante se realizó una evaluación basal antes del inicio de la TEC y otras dos (una a la semana y otra a los seis meses) después de terminado el ciclo de tratamientos, para describir el efecto de la TEC frontotemporal bilateral en la función neurocognitiva mediante el cambio, desde el estado basal hasta la evaluación final en los dominios de memoria, velocidad psicomotora, tiempo de reacción, atención compleja y flexibilidad cognoscitiva, así como en la función cognoscitiva global; y determinar su seguridad por el reporte de eventos adversos. La evaluación cognitiva se realizó con una batería de pruebas neuropsicológicas y la severidad de la enfermedad psiquiátrica se evaluó con la escala Clinical Global Impression Severity (CGI-S). Se incluyeron seis pacientes remitidos para t...

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“…Recent reports have suggested the presence of persistent cognitive impairments in patients diagnosed with BD even after prolonged euthymic phases [16,26,[40][41][42][43][44][45][46][47][48]. Review by Torres et al [4] revealed widespread cognitive deficits in tests assessing attention, speed of information processing, memory and executive dysfunctions in remitted bipolars versus controls.…”

Section: Cognitive Functions In Bipolar Patientsmentioning

confidence: 99%

“…Burdick [64] has not detected a direct relationship between attention deficits and depressive symptoms. Sustained attention deficits apparent during the euthymic period of bipolar disorder cannot be explained in terms of working memory impairment and represent a reduced inherent capacity rather than a changed response bias [16,42,44,45,53,65,66]. Sustained attention deficits are claimed to be a core deficit for bipolar disorder, but those deficits are not dependent on executive dysfunctions, including working memory.…”

Section: Cognitive Functions In Bipolar Patientsmentioning

confidence: 99%