Persistent buccopharyngeal membrane

Kara, Cüneyt Orhan; Kara, İnci

doi:10.1016/j.otohns.2006.12.016

Cited by 12 publications

(6 citation statements)

References 3 publications

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“…10 In the 9th week, the mandible grows down and lengthens, causing the tongue to retract inferiorly and allowing the palatine shelves to elevate and fuse at midline. 10 During week 6 or 7, aberrant fusion could take place between the inferiorly displaced palatine shelves and the floor of the mouth. If these attachments are not obliterated with vertical growth of the face, the result is a subglossopalatal membrane.…”

Section: Discussionmentioning

confidence: 99%

“…In the 7th week of normal development, the palatine shelves are positioned vertically. Skeletal muscle growth of the tongue combined with relative mandibular hypoplasia causes the tongue to wedge itself between the palatine shelves 10 . In the 9th week, the mandible grows down and lengthens, causing the tongue to retract inferiorly and allowing the palatine shelves to elevate and fuse at midline 10 .…”

Section: Discussionmentioning

confidence: 99%

“…Skeletal muscle growth of the tongue combined with relative mandibular hypoplasia causes the tongue to wedge itself between the palatine shelves 10 . In the 9th week, the mandible grows down and lengthens, causing the tongue to retract inferiorly and allowing the palatine shelves to elevate and fuse at midline 10 . During week 6 or 7, aberrant fusion could take place between the inferiorly displaced palatine shelves and the floor of the mouth.…”

Section: Discussionmentioning

confidence: 99%

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Subglossopalatal Membrane With Associated Cleft Palate, Cardiovascular, and Neurologic Anomalies

Engel

Greenberg

Rozzelle

2021

Journal of Craniofacial Surgery

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Subglossopalatal membrane (or subglossopalatal synechia) is a rare clinical entity that can lead to respiratory distress and feeding difficulty due to oral obstruction. Here, the authors present a case of subglossopalatal membrane with associated cleft palate and cardiovascular and neurologic anomalies that was treated with surgical excision and lip-tongue adhesion. Etiology of these membranes is believed to be intrauterine fetal insult. Membranes should be treated with excision, whereas taking care to ensure patency of the airway. Presence of a subglossopalatal membrane should prompt thorough examination for additional congenital anomalies.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Subglossopalatal Membrane With Associated Cleft Palate, Cardiovascular, and Neurologic Anomalies

Engel

Greenberg

Rozzelle

2021

Journal of Craniofacial Surgery

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“…When the buccopharyngeal membrane does not rupture, it results in a medical condition called persistent buccopharyngeal membrane [20][21][22][23]. While rare on its own, this condition also appears to be present in a number of craniofacial syndromes such as 1p36 deletion syndrome (OMIM #607872), Hypomandibular faciocranial dysostosis (OMIM #241310) Agnathia-otocephaly complex (OMIM #202650), microphthalmia, syndromic 5 (OMIM # 610125) and Holzgreve-Wagner-Rehder syndrome (OMIM # 236110) [24,25].…”

Section: Introductionmentioning

confidence: 99%

Jak2 and Jaw Muscles Are Required for Mouth Development

Dickinson¹

2023

Preprint

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The mouth is a central feature of our face, without it we could not eat, breathe, nor communicate. A critical and early event in mouth formation is the creation of a “hole” which connects the digestive system and the external environment. This hole, which has also been called the primary or embryonic mouth in vertebrates, is initially covered by a 1-2 cell layer thick structure called the buccopharyngeal membrane. When the buccopharyngeal membrane does not rupture it impairs early mouth functions and may also lead to further craniofacial malformations. Using a chemical screen in an animal model (Xenopus laevis) and genetic data from humans, we determined that Janus kinase 2 (Jak2) could have a role in buccopharyngeal membrane rupture. We have determined that decreased Jak2 function, using antisense morpholinos or a pharmacological antagonist, caused a persistent buccopharyngeal membrane as well as the loss of jaw muscles. Surprisingly, we observed that the jaw muscle compartments were connected to the oral epithelium that is continuous with the buccopharyngeal membrane. Severing such connections resulted in buccopharyngeal membrane buckling and persistence. We also noted puncta accumulation of F-actin, an indicator of tension, in the buccopharyngeal membrane during perforation. Together the data has led us to a hypothesis where muscles are required to exert tension across the buccopharyngeal membrane, and such tension is necessary for its perforation.

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“…When the buccopharyngeal membrane fails to perforate in humans it causes a defect known as persistent buccopharyngeal membrane [12, 13]. This condition on its own is very rare but can also present in conjunction with other congenital syndromes (Table 1A) and cleft palate [14–16].…”

Section: Introductionmentioning

confidence: 99%

Using frogs faces to dissect the mechanisms underlying human orofacial defects

Dickinson

2016

Seminars in Cell & Developmental Biology

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In this review I discuss how Xenopus laevis is an effective model to dissect the mechanisms underlying orofacial defects. This species has been particularly useful in studying the understudied structures of the developing face including the embryonic mouth and primary palate. The embryonic mouth is the first opening between the foregut and the environment and is critical for adult mouth development. The final step in embryonic mouth formation is the perforation of a thin layer of tissue covering the digestive tube called the buccopharyngeal membrane. When this tissue does not perforate in humans it can pose serious health risks for the fetus and child. The primary palate forms just dorsal to the embryonic mouth and in non-amniotes it functions as the roof of the adult mouth. Defects in the primary palate result in a median oral cleft that appears similar across the vertebrates. In humans, these median clefts are often severe and surgically difficult to repair. Xenopus has several qualities that make it advantageous for craniofacial research. The free living embryo has an easily accessible face and we have also developed several new tools to analyze the development of the region. Further, Xenopus is readily amenable to chemical screens allowing us to uncover novel gene-environment interactions during orofacial development, as well as to define underlying mechanisms governing such interactions. In conclusion, we are utilizing Xenopus in new and innovative ways to contribute to craniofacial research.

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Persistent buccopharyngeal membrane

Cited by 12 publications

References 3 publications

Subglossopalatal Membrane With Associated Cleft Palate, Cardiovascular, and Neurologic Anomalies

Subglossopalatal Membrane With Associated Cleft Palate, Cardiovascular, and Neurologic Anomalies

Jak2 and Jaw Muscles Are Required for Mouth Development

Using frogs faces to dissect the mechanisms underlying human orofacial defects

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