Persistent chemosis and periorbital edema

Chronic Lymphocytic Leukemia Presenting as Bilateral Periorbital Edema Treated With Low-dose Radiation Therapy

“…10,14 The mechanism of cutaneous infiltration is not fully understood but is thought to be due to an interaction between intercellular adhesion molecules of the lymphocytes and endothelial cells. 14 Cutaneous infiltration has also been reported to be triggered by antigenic stimulation at sites of prior infections and in areas of epidermal trauma. 11,15 The diagnosis of CLL involves detection of mature, monoclonal malignant B lymphocytes through flow cytometry or biopsy.…”

“…11 There have been 2 other case reports to date of leukemia cutis presenting as periorbital edema. 10,14 The mechanism of cutaneous infiltration is not fully understood but is thought to be due to an interaction between intercellular adhesion molecules of the lymphocytes and endothelial cells. 14 Cutaneous infiltration has also been reported to be triggered by antigenic stimulation at sites of prior infections and in areas of epidermal trauma.…”

“…10 Shantha et al described a case of periorbital chemosis and edema which improved after bendamustine and rituximab therapy. 14 Low-dose radiation therapy (4 Gy in 2 2-Gy fractions) has been successfully described in the treatment of indolent B-cell ocular adnexal lymphoma. 24 In our case, given the patient’s superior visual field restrictions and localized symptoms, a multidisciplinary team decision was made to proceed with palliative radiation therapy.…”