Persistent coagulopathy in snake bite

Khadwal, Alka; Bharti, Bhavneet; Poddar, Banani; Basu, Srikant; Virdi, Virender Singh; Parmar, Veena R.

doi:10.1007/bf02723621

Cited by 2 publications

(3 citation statements)

References 8 publications

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“…Although the previous studies suggested that serious coagulopathy such as DIC rarely happened because venom was absorbed into the blood in only a small number of cases, in this study, the prevalence of DIC after poisonous snake bite was not considered to be low. In present study the PT/APTT was prolonged in 101 (90%) subjects, thrombocytopenia in 93(83%) patients and hypofibrinogemia in 81(72%) individuals, the findings are consistent with they study by Khadwal A, et al and Li QB, et al 27,28…”

Section: Discussionsupporting

confidence: 92%

Snake Bite

Ansari

Hussain

Shah

et al. 2015

TPMJ

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Snake bites are increasing amongst those who unlawfully keep snakes as petsworldwide. The rural population active in agricultural works, laborers, herders, professionalsnake handlers, trekkers, snake charmers and fishermen are at risk for snake bites. Objectives:To determine the frequency and pattern of vasculotoxic effects in patients with snake bite.Design: Case Study. Period: Six Months Setting: Liaquat University Hospital Hyderabad.Patients and methods: All the patients who initially present in casualty department of hospitalwith the history of snake bite were enrolled in the study. The vasculotoxic effects were evaluatedby whole blood clotting time (WBCT) test, bleeding time, PT/APTT, hypofibrinogemia, DIC andthrombocytopenia. Relevant information would be entered in specifically designed proformafor this study. The data was entered, saved and analyzed in SPSS. So no test of significancewould be applied. Results: Out of 140 patients 112(80%) had vasculotoxic effects, of which80(72%) were males and 32(28%) were females. The mean age ±SD of the overall patients was37.53±8.72 whereas the mean age ±SD of male and female population was 38.98±7.44 and34.88±4.32 respectively. The systemic bleeding was observed in 99% patients, the fang marksin 94 patients, the prolonged bleeding time, WBCT and PT/APTT in 103, 96 and 101 patients,thrombocytopenia in 93 patients, hypofibrinogemia in 81 patients and DIC in 76 patients.The hamaturia (22%), hamoptysis(16%) and hametemesis (11%) was predominant features.The gangrene was observed in 02 patients, vomiting was observed in 60% of patients hadhaematemesis in 11%, bleeding gums in 03 cases and haemoptysis in 16%. Renal failure wasobserved in 12 cases. Conclusions: The coagulation tests disturbed as venom increases theclotting time. Proteins digesting enzymes or thrombin like activity of venom may be one of thecauses for prolongation coagulation tests (vasculotoxic effects)

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Section: Discussionsupporting

confidence: 92%

Snake Bite

Ansari

Hussain

Shah

et al. 2015

TPMJ

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Section: Introductionmentioning

confidence: 99%

“…10 Prolonged bleeding disorders, even after antivenom immunotherapy, have been described and various explanations have been suggested, such as temporary decrease in antivenin levels, rapid elimination of antivenin from circulation or the continuous release of unneutralized venom from the envenomation site. 11 Less than 25% of antivenom needs are effectively covered and in most envenomations are probably given in insufficient doses. 10 The procurement of antivenom has become increasingly difficult and expensive in Africa.…”

Section: Introductionmentioning

confidence: 99%

Snake bites in Moyen Chari district, Chad: a five-year experience

2011

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Snake bites are of major public health importance in Africa as a cause of morbidity and mortality. Echis ocellatus is responsible for the majority of envenomation cases in West Africa. Antivenom immunotherapy is the only specific treatment available for envenomed patients. From January 1997 to December 2001, 325 patients suffering from snake bites were enrolled in a survey undertaken at Goundi Hospital, Chad. We analysed the percentage of envenomed patients, sex distribution, distribution along the year, lethality, hospital stay and recovery clotting time. Two hundred and ninety-eight patients showed signs of envenomation and were treated with antivenom immunotherapy with three different sera in consecutive periods. Young males were more frequently involved. The overall lethality was 8%. Lethality and hospital stay were significantly different in the differently treated patients. Most of the data in our series were similar to those from other sub-Saharan countries but, overall, the percentage of snake bite victims who were admitted to hospital was higher.

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Persistent coagulopathy in snake bite

Cited by 2 publications

References 8 publications

Snake Bite

Snake Bite

Snake bites in Moyen Chari district, Chad: a five-year experience

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