Persistent Diarrhoea: A Preliminary Report on Clinical Features and Dietary Therapy in Bangladeshi Children

Roy, Swapan Kumar; Alam, A. N.; Majid, N; Khan, Arifuzzaman; Hamadani, Jena D.; Shome, G.P.

doi:10.1093/tropej/35.2.55

Cited by 26 publications

(17 citation statements)

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“…Alternatively, it might reflect increased fluid loss due to a less efficient absorptive mechanism. In our previous study, 88% of children with persistent diarrhoea lost body weight during their illness (21). The present study showed enhanced clinical recovery with zinc supplementation in the children who were underweight (Ͻ70 weight for age), the group at greatest risk for morbidity and mortality.…”

Section: Discussionsupporting

confidence: 65%

Impact of zinc supplementation on persistent diarrhoea in malnourished Bangladeshi children

Roy¹

1998

Acta Paediatrica

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To evaluate the impact of zinc supplementation on the clinical recovery and body weight of children with persistent diarrhoea, a randomized, double-blind, controlled trial was conducted in 190 children with persistent diarrhoea aged between 3 and 24 months. Children were randomly allocated to receive either zinc (20 mg d(-1)) syrup with multivitamin (2 x RDA) or multivitamin alone in three divided daily doses for 2 weeks. The trial was conducted in a diarrhoeal disease hospital in Dhaka, Bangladesh. Duration until clinical recovery (d), impact on body weight and serum zinc level after 2 weeks of zinc supplementation were recorded. The duration of illness was significantly reduced (33%) with zinc supplementation among children who were underweight (< or =70% wt/age, p = 0.03). Supplemented male children also had a significant reduction (27%) in duration for recovery compared with unsupplemented children (p = 0.05). From baseline to convalescence, zinc-supplemented children maintained their serum zinc concentration (13.4 vs 13.6 micromol l(-1)), whereas unsupplemented children had a decrease in serum zinc after the 2 weeks of diarrhoea (13.6 vs 11.8 micromol l(-1),p < 0.03). The mean body weight of the children in the supplemented group was maintained (5.72 vs 5.70 kg, p = 0.62) during hospitalization, unlike that of the control group, in which there was a reduction in body weight (5.75 vs 5.67 kg, p = 0.05). Five children in the unsupplemented group and one child in the zinc-supplemented group died during the 2 weeks of supplementation (p = 0.06). Zinc supplementation in persistent diarrhoea significantly reduced the length of the recovery period in malnourished children and prevented a fall in body weight and serum zinc concentration, indicating that zinc is a beneficial therapeutic strategy in this high-risk childhood illness.

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Section: Discussionsupporting

confidence: 65%

Impact of zinc supplementation on persistent diarrhoea in malnourished Bangladeshi children

Roy¹

1998

Acta Paediatrica

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“…9,15 The case fatality in this study was 8.3% which is similar to studies from India and Bangladesh. 16,17 Though maximum number of PD was observed in infancy, highest mortality was in the age group of one to five yrs. This is consistent with the observation from Bangladesh 1 , though higher mortality in younger age group has been reported from India and Turkey.…”

Section: Discussionmentioning

confidence: 97%

Persistent diarrhea: Risk factors and outcome

et al. 2010

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“…If this is unsuccessful a comminuted chicken diet is given. 22 In our study, we used comminuted chicken diet because this diet is free of fibres and complex carbohydrates. This was intended to examine the effects of Benefiber supplementation.…”

Section: Discussionmentioning

confidence: 99%

Partially hydrolysed guar gum supplemented comminuted chicken diet in persistent diarrhoea: a randomised controlled trial

Alam

2005

Archives of Disease in Childhood

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Background: Partially hydrolysed guar gum (Benefiber) added to a diet is fermented in the colon, producing short chain fatty acids, which improve intestinal function, including colonic salt and water absorption. Aims: To evaluate the effect of Benefiber supplemented comminuted chicken diet in the treatment of persistent diarrhoea. Methods: One hundred and sixteen children (aged 5-24 months), presenting to Dhaka Hospital with a history of watery diarrhoea for more than 14 days (persistent diarrhoea), were randomised to receive either: (1) comminuted chicken diet with Benefiber (study diet); or (2) comminuted chicken diet without Benefiber (control diet). The study period was seven days. Results: Of 116 children, 57 received the study diet and 59 received the control diet. Diarrhoea resolved in a greater number of children with the study than with the control diet (46/55 (84%) v 36/58 (62%); odds ratio 3.12, 95% CI 1.19 to 8.4). Survival analysis for the duration of diarrhoea also showed a reduced duration of diarrhoea in children receiving the study diet. There was also a trend in daily stool reduction in children receiving the study diet, significant on days 4-7. Conclusion: Results show that Benefiber supplemented comminuted chicken diet enhances recovery of children with persistent diarrhoea, indicating its therapeutic potential.

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Persistent Diarrhoea: A Preliminary Report on Clinical Features and Dietary Therapy in Bangladeshi Children

Cited by 26 publications

References 0 publications

Impact of zinc supplementation on persistent diarrhoea in malnourished Bangladeshi children

Impact of zinc supplementation on persistent diarrhoea in malnourished Bangladeshi children

Persistent diarrhea: Risk factors and outcome

Partially hydrolysed guar gum supplemented comminuted chicken diet in persistent diarrhoea: a randomised controlled trial

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