Persistent efficacy of topical eprinomectin against nematode parasites in cattle

Abstract

Six studies were conducted to evaluate the persistent efficacy of eprinomectin pour-on against experimental challenges with infective nematode larvae in calves. In each study, calves were randomly assigned to one untreated group and up to four test groups, which were treated with eprinomectin at 500 microg/kg body weight at weekly intervals before single bolus challenge. The calves were necropsied approximately 4 weeks after challenge infection for nematode recovery. Eprinomectin pour-on provided > or =90% efficacy against challenge with Haemonchus placei, Trichostrongylus axei and T. colubriformis at 21 days after treatment and against Cooperia oncophora, C. punctata, C. surnabada, Dictyocaulus viviparus, Nematodirus helvetianus, Oesophagostomum radiatum and Ostertagia ostertagi at 28 days after treatment.

Evaluation of the pour-on administration of eprinomectin on milk yield and somatic cell counts in dairy ewes naturally infected with gastrointestinal nematodes

“…In our study, a long term effect of eprinomectin was evidenced. This has also been reported by other studies assessing the effectiveness of pour-on eprinomectin against experimental or natural GIN infection of goats ( Chartier et al, 1999 ) and cattle ( Cramer et al, 2000 ) for a period over 28 days post treatment.…”

Gastrointestinal nematodes of goats: host–parasite relationship differences in breeds at summer mountain pasture in northern Italy

“…In particular, the lower egg excretion observed in the July sampling, three weeks after treatment, was probably due to the immediate efficacy of the administered drug (9), whereas the prolonged lower excretion in the following samplings could also be due to other factors. Firstly, pour-on eprinomectin is known for its persistent efficacy, mainly in cattle (7,12). Probably, as observed by Chartier and Pors (5), its persistence is shorter in goats, although pour-on eprinomectin at a dose of 1 mg/kg b.w.…”

Efficacy of eprinomectin pour-on treatment in sheep naturally infected withDictyocaulus filariaandCystocaulus ocreatus

“…It is available on the market at a pour-on dose of 0.5 mg/kg for cattle (Shoop et al , 1996). Eprinomectin has been reported to be highly effective against ectoparasite infestations in farm animals (Aguirre et al , 2005; Rehbein et al , 2005; Habela et al , 2006), immature and adult gastrointestinal nematodes in cattle (Shoop et al , 1996; Pitt et al , 1997; Williams et al , 1997; Cramer et al , 2000) and Dictyocaulus viviparus (Shoop et al , 1996; Pitt et al , 1997; Williams et al , 1997; Cramer et al , 2000; Höglund et al , 2003). Evaluation of the effect of eprinomectin against lungworm infections in small ruminants has been performed in goats only and has been reported to be 100% effective against Muellerius capillaris (Geurden & Vercruysse, 2007).…”