Persistent elevation of plasma vascular endothelial growth factor levels during the first month after minimally invasive colorectal resection

Belizon, Avraham; Balık, Emre; Horst, Patrick; Feingold, Daniel L.; Arnell, Tracey D.; Azarani, T.; Cekic, Vesna; Skitt, R.; Kumara, S.; Whelan, Richard L.

doi:10.1007/s00464-007-9725-7

Cited by 45 publications

(44 citation statements)

References 40 publications

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“…VEGF release following surgery may be undesirable, since it may enhance tumor growth and metastasis formation on residual tumor cells. Elevated circulating levels of VEGF were found following major abdominal surgery from several days up till 4 weeks postoperatively [47,48]. Interestingly, the release of VEGF were significantly higher in the open abdominal surgical patients compared with laparoscopic approach to colectomy, irrespective of whether surgery was for benign or malignant pathology [48].…”

Section: Cellular Immunitymentioning

confidence: 99%

Surgical Trauma and Immune Functional Changes Following Major Lung Resection

Lau

2013

Indian J Surg

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Video-assisted thoracic surgery (VATS) has evolved greatly over the last two decades. VATS major lung resection for early stage non-small cell lung carcinoma (NSCLC) has been shown to result in less postoperative pain, less pulmonary dysfunction postoperatively, shorter hospital stay, and better patient tolerance to adjuvant chemotherapy compared with patients who underwent thoracotomy. Several recent studies have even reported improved long-term survival in those who underwent VATS major lung resection for early stage NSCLC when compared with open technique. Interestingly, the immune status and autologous tumor killing ability of lung cancer patients have previously been associated with long-term survival. VATS major lung resection can result in an attenuated postoperative inflammatory response. Furthermore, the minimal invasive approach better preserve patients' postoperative immune function, leading to higher circulating natural killer and T cells numbers, T cell oxidative activity, and levels of immunochemokines such as insulin growth factor binding protein 3 following VATS compared with thoracotomy. Apart from host immunity, the angiogenic environment following surgery may also have a role in determining cancer recurrence and possibly survival. Whether differences in immunological and biochemical mediators contribute significantly towards improved clinical outcomes following VATS major lung resection for lung cancer remains to be further investigated. Future studies will also need to address whether the reduced access trauma from advanced thoracic surgical techniques, such as single-port VATS, can further attenuate the postoperative inflammatory response.

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Section: Cellular Immunitymentioning

confidence: 99%

Surgical Trauma and Immune Functional Changes Following Major Lung Resection

Lau

2013

Indian J Surg

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“…Plasma levels of the following proangiogenic proteins have been shown to be persistently increased after minimally invasive colorectal resection (MICR): Vascular endothelial growth factor (VEGF), angiopoeitin-2 (Ang-2), placental growth factor (PIGF), soluble vascular adhesion molecule-1 (sVCAM-1), monocyte chemotactic protein-1 (MCP-1), human chitinase 3-like 1 (Chi3L1), matrix metalloproteinase-3 (MMP-3), and others (11)(12)(13)(14)(15)(16). It has also been shown via in vitro endothelial cell (EC) culture studies that plasma from weeks 2 and 3 after MICR significantly stimulates endothelial cells to proliferate, migrate, and invade when compared to EC culture results obtained with the same patients preoperative plasma (12,17); these EC activities are critical to angiogenesis.…”

Section: Introductionmentioning

confidence: 99%

Plasma interleukin-8 levels are persistently elevated for 1ï¿½month after minimally invasive colorectal resection for colorectal cancer

Kumara¹,

Sutton²,

Bellini³

et al. 2017

mol clin onc

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Abstract. Minimally invasive colorectal resection (MICR) for colorectal cancer (CRC) is associated with elevated levels of seven proangiogenic proteins that persist for 2-4 weeks after surgery. The proangiogenic plasma may promote tumor growth postoperatively in patients with residual cancer. To the best of our knowledge, the impact of surgery on interleukin 8 (IL-8) levels is unknown. The aim of the present study was to evaluate plasma IL-8 levels after MICR for CRC. Patients with CRC enrolled in an institutional review board-approved plasma/data bank who underwent MICR were eligible. Blood samples were taken preoperatively (preop) and at multiple postoperative (postop) time points, and were stored at -80˚C. Only patients for whom preop, postop day (POD) 1, POD 3 and at least 1 late postop plasma samples (POD7-34) available were enrolled. Clinical, demographical and pathological data were collected. IL-8 levels were determined via ELISA and results were reported as the mean and ± standard deviation. The Wilcoxon signed rank test was used for analysis with P<0.05 used as the significance threshold. A total of 73 CRC patients (colon, 62%; rectal, 38%) who underwent MICR (laparoscopic-assisted, 60%; hand-assisted, 40%) were studied. The mean preop IL-8 level was 20.4±10.6 pg/ml. Significant elevations in plasma IL-8 levels were noted compared with preop levels on POD1 (43.1±38.6; n=72; P<0.0001), POD 3 (33.0±30.1; n=71; P<0.0001), POD7-13 (29.9±21.9; n=50; P<0.0001), n=24; P=0.002), and for the POD21-27 time point (24.0±9.2; n=16; P= 0.002). In conclusion, plasma IL-8 levels were significantly elevated from baseline for 4 weeks after MICR for CRC. In conjunction with the other proangiogenic MICR-associated blood compositional changes, increased IL-8 levels may promote tumor angiogenesis and growth postop.

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“…However, some of the proteins affected by surgery, for example IGFBP-3 and MMP-9, may influence cancer growth; of note, the majority of postoperative changes within this group of proteins facilitate and encourage tumor growth [3,5]. Recently, it has been noted that plasma VEGF levels are elevated after colorectal resection and that increased concentrations persist for 2-3 weeks [6]. VEGF is an important promoter of angiogenesis, which is a critical component of both wound healing and tumor growth.…”

Section: Introductionmentioning

confidence: 99%

Colorectal resection, both open and laparoscopic-assisted, in patients with benign indications is associated with proangiogenic changes in plasma angiopoietin 1 and 2 levels

et al. 2008

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CR for benign pathology results in higher Ang 2 levels, lower Ang 1 levels, and lower Ang 1 to Ang 2 ratios early after surgery. These alterations are proangiogenic. These results, plus the already noted VEGF increases, suggest that surgery results in proangiogenic plasma protein changes that may stimulate tumor growth early after surgery. The duration of the Ang 1 and 2 changes needs to be determined.

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Persistent elevation of plasma vascular endothelial growth factor levels during the first month after minimally invasive colorectal resection

Cited by 45 publications

References 40 publications

Surgical Trauma and Immune Functional Changes Following Major Lung Resection

Surgical Trauma and Immune Functional Changes Following Major Lung Resection

Plasma interleukin-8 levels are persistently elevated for 1ï¿½month after minimally invasive colorectal resection for colorectal cancer

Colorectal resection, both open and laparoscopic-assisted, in patients with benign indications is associated with proangiogenic changes in plasma angiopoietin 1 and 2 levels

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