Persistent ferroptosis promotes cervical squamous intraepithelial lesion development and oncogenesis by regulating KRAS expression in patients with high risk-HPV infection

Wang, Tianming; Gong, Min; Cao, Yuting; Zhao, Chengcheng; Lu, Yuan-Qiang; Zhou, Yu; Yao, Shasha; Chen, Jianquan; Zhao, Chun; Ju, Rong

doi:10.1038/s41420-022-01013-5

Cited by 16 publications

(17 citation statements)

References 37 publications

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“…In addition, we found ferroptosis rather than apoptosis in NPC1-deficient HEI-OC1 cells. As we know, features of ferroptosis are different from those of apoptosis, with significant increase of Fe (II) content and exceeding lipid peroxide levels which are harmful to the mitochondria (Dixon et al, 2012;Wang et al, 2022). There have been some studies of NPCD on the effect of NPC1 deficiency and mental disorders.…”

Section: Discussionmentioning

confidence: 99%

NPC1 Deficiency Contributes to Autophagy-Dependent Ferritinophagy in HEI-OC1 Auditory Cells

Liang

Wang

et al. 2022

Front. Mol. Biosci.

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Niemann–Pick type C disease (NPCD) is a rare genetic syndrome characterized by cholesterol accumulation in multiple organelles. NPCD is mainly caused by gene deficiency of NPC intracellular cholesterol transporter 1 (NPC1). It has been reported that some of the NPCD patients exhibit clinical features of progressive hearing loss at high frequency and iron disorder, but the underlying relationship is unknown. A recent study has reported that ferroptosis contributes to the impairment of cochlear hair cells that are related to sensory hearing. In this study, we generated NPC1-deficient HEI-OC1 cells to show the effect of NPC1 deficiency on cochlear outer hair cells. We found that NPC1 deficiency enhances autophagy-dependent ferritinophagy to release Fe (II). Our work provides important insights into the effect of NPC1 deficiency in auditory cells, indicating that it induces ferroptosis and results in hearing loss.

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Section: Discussionmentioning

confidence: 99%

NPC1 Deficiency Contributes to Autophagy-Dependent Ferritinophagy in HEI-OC1 Auditory Cells

Liang

Wang

et al. 2022

Front. Mol. Biosci.

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“…In recent years, medicines designed as ferroptosis inducer are becoming new approach for clinical cancer therapy 130,131 . However, tumor cells can increase antioxidant genes to confer ferroptosis, which may even promote tumor development 126,132 . Further investigations exploring the mechanism of RPTPs and ferroptosis in cancers should be carried out.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

The role of receptor‐type protein tyrosine phosphatases in cancer

Wang

Cao

et al. 2023

Precision Medical Sciences

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Receptor-type protein tyrosine phosphatases (RPTPs), Class I protein tyrosine phosphatases, are involved in human tumor cell proliferation, apoptosis, migration, and invasion through reversible phosphorylation of tyrosine residues. This review summarizes the expression and role of RPTPs in cancer and illustrates the signaling pathway mechanisms of effecting oncogenesis, tumor progression, prognosis, and angiogenesis, so as to provide more effective targets for gene therapy of related cancers.

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“…Ferroptosis, however, does not always have an anti-tumor impact. According to Wang et al [57], an anti-ferroptosis impact would be triggered by prolonged ferroptosis. This effect raises the Kirsten rat sarcoma viral oncogene homolog (KRAS), which accelerates the development of squamous cell carcinoma (SCC) [57].…”

Section: Ferroptosis and Cervical Cancermentioning

confidence: 99%

“…According to Wang et al [57], an anti-ferroptosis impact would be triggered by prolonged ferroptosis. This effect raises the Kirsten rat sarcoma viral oncogene homolog (KRAS), which accelerates the development of squamous cell carcinoma (SCC) [57]. Additionally, Liu et al discovered that miR-193a-5p/GPX4 and circular RNA circACAP2 prevented ferroptosis in cervical cancer's malignant progression [58].…”

Section: Ferroptosis and Cervical Cancermentioning

confidence: 99%

Ferroptosis’s Role in Genitourinary System Cancer

Liu¹,

Yang²,

Wang³

et al. 2022

Oncologie

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A cell is the basic unit of life, and death is inevitable for any cell. However, cancer cells that deviate from the normal track can resist death and survive. Ferroptosis is recently discovered as a modulated cell death different from other known forms of cell death in morphology, biochemistry, and genetics. It is characterized by irondependent lipid peroxidation regulated by various metabolic pathways. The incidence and mortality of genitourinary system cancer have been increasing recently. Although clinical practice therapy techniques have improved, no plan with a positive prognosis has been identified. For the therapy of cancer, ferroptosis opens up new avenues. Many studies have shown a complex link between ferroptosis and cancer, while some studies have also found the role of ferroptosis in genitourinary system-related cancers and therapeutic prospects. This article reviews the ferroptosis research progress in genitourinary system cancers, including bladder cancer, prostate cancer, ovarian cancer, and cervical cancer. It will also provide new ideas for the treatment of these cancers.

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Persistent ferroptosis promotes cervical squamous intraepithelial lesion development and oncogenesis by regulating KRAS expression in patients with high risk-HPV infection

Cited by 16 publications

References 37 publications

NPC1 Deficiency Contributes to Autophagy-Dependent Ferritinophagy in HEI-OC1 Auditory Cells

NPC1 Deficiency Contributes to Autophagy-Dependent Ferritinophagy in HEI-OC1 Auditory Cells

The role of receptor‐type protein tyrosine phosphatases in cancer

Ferroptosis’s Role in Genitourinary System Cancer

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