Persistent gross lipemia and suspected corneal lipidosis following intravenous lipid therapy in a cat with permethrin toxicosis

Seitz, Marc A.; Creedon, Jamie M. Burkitt

doi:10.1111/vec.12440

Cited by 21 publications

(18 citation statements)

References 16 publications

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“…Most of the potential risks of ILE can be extrapolated from parenteral nutrition administration and include “fat overload syndrome” causing fat embolism, hemolysis, hyperlipidemia, and increased clotting times; volume overload; pancreatitis; nausea and vomiting . Specific to cats, two cases of corneal lipidosis have been reported following ILE administration for permethrin toxicosis . Both of these cats received well over the recommended 10% of total blood volume dose, and the only side effect noted was corneal lipidosis in conjunction with persistent lipemia and hypertriglyceridemia.…”

Section: Discussionmentioning

confidence: 99%

“…26 Specific to cats, two cases of corneal lipidosis have been reported following ILE administration for permethrin toxicosis. 27,28 Both of these cats received well over the recommended 10% of total blood volume dose, and the only side effect noted was corneal lipidosis in conjunction with persistent lipemia and hypertriglyceridemia. A recent study reviewing the effects of ILE on amitriptyline in the rat model postulated that an increased hemodynamic instability was noted in rats given ILE was due to enhancement of drug absorption from the GI tract.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Use of intravenous lipid therapy in a cat with carprofen overdose

Chumbler

Schildt

Mawby

et al. 2020

Clinical Case Reports

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Use of intravenous lipid therapy in a cat with carprofen overdose

Chumbler

Schildt

Mawby

et al. 2020

Clinical Case Reports

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“…In a case series, one dog had swelling and pain associated with extravasation of the ILE (Bates et al, 2013). There is a single case report of a cat which presented with persistent gross lipaemia and suspected corneal lipidosis following treatment for ivermectin toxicity with ILE (Seitz et al, 2016). Since there are no current studies evaluating the safety of ILE use in acute toxicities (Kuo et al, 2013), owners should be informed of its off-label use (Haworth et al, 2012).…”

Section: Resultsmentioning

confidence: 99%

Use of Intravenous Lipid Emulsion in Dogs With Suspected Tremorgenic Mycotoxicosis: 53 Cases

Kormpou

O’Sullivan

Troth

et al. 2018

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“…A total of 56 studies were included in the update, from which eleven were animal reports, two regarding LA and nine non-LA poisonings. [33][34][35][36][37][38][39][40][41][42][43]. Forty-five human reports, eight regarding LA and 37 non-LA were included.…”

Section: Literature Updatementioning

confidence: 99%

Evidence-based recommendations on the use of intravenous lipid emulsion therapy in poisoning

Gosselin

Hoffman

et al. 2016

Clinical Toxicology

134

104

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Background: Although intravenous lipid emulsion (ILE) was first used to treat life-threatening local anesthetic (LA) toxicity, its use has expanded to include both non-local anesthetic (non-LA) poisoning and less severe manifestations of toxicity. A collaborative workgroup appraised the literature and provides evidence-based recommendations for the use of ILE in poisoning. Methods: Following a systematic review of the literature, data were summarized in four publications: LA and non-LA poisoning efficacy, adverse effects, and analytical interferences. Twenty-two toxins or toxin categories and three clinical situations were selected for voting. Voting statements were proposed using a predetermined format. A two-round modified Delphi method was used to reach consensus on the voting statements. Disagreement was quantified using RAND/UCLA Appropriateness Method. Results: For the management of cardiac arrest, we recommend using ILE with bupivacaine toxicity, while our recommendations are neutral regarding its use for all other toxins. For the management of life-threatening toxicity, (1) as first line therapy, we suggest not to use ILE with toxicity from amitriptyline, non-lipid soluble beta receptor antagonists, bupropion, calcium channel blockers, cocaine, diphenhydramine, lamotrigine, malathion but are neutral for other toxins, (2) as part of treatment modalities, we suggest using ILE in bupivacaine toxicity if other therapies fail, but are neutral for other toxins, (3) if other therapies fail, we recommend ILE for bupivacaine toxicity and we suggest using ILE for toxicity due to other LAs, amitriptyline, and bupropion, but our recommendations are neutral for all other toxins. In the treatment of non-life-threatening toxicity, recommendations are variable according to the balance of expected risks and benefits for each toxin. For LA-toxicity we suggest the use of Intralipid V R 20% as it is the formulation the most often reported. There is no evidence to support a recommendation for the best formulation of ILE for non-LAs. The voting panel is neutral regarding ILE dosing and infusion duration due to insufficient data for non-LAs. All recommendations were based on very low quality of evidence. Conclusion: Clinical recommendations regarding the use of ILE in poisoning were only possible in a small number of scenarios and were based mainly on very low quality of evidence, balance of expected risks and benefits, adverse effects, laboratory interferences as well as related costs and resources. The workgroup emphasizes that dose-finding and controlled studies reflecting human poisoning scenarios are required to advance knowledge of limitations, indications, adverse effects, effectiveness, and best regimen for ILE treatment.

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Persistent gross lipemia and suspected corneal lipidosis following intravenous lipid therapy in a cat with permethrin toxicosis

Abstract: This is the first report documenting the complications of persistent gross lipemia and suspected corneal lipidosis in a cat following IVLT. This report underscores the off-label, experimental nature of IVLT as a treatment for intoxication in cats.

Cited by 21 publications

References 16 publications

Use of intravenous lipid therapy in a cat with carprofen overdose

Use of intravenous lipid therapy in a cat with carprofen overdose

Use of Intravenous Lipid Emulsion in Dogs With Suspected Tremorgenic Mycotoxicosis: 53 Cases

Evidence-based recommendations on the use of intravenous lipid emulsion therapy in poisoning

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