Persistent immunosuppressive effects of dibutyl phthalate exposure in adult male mice

Pierozan, Paula; Källsten, Liselott; Theodoropoulou, Eleftheria; Almamoun, Radwa; Karlsson, Oskar

doi:10.1016/j.scitotenv.2023.162741

Cited by 16 publications

(2 citation statements)

References 75 publications

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“…The immune landscape plays a pivotal role in shaping the clinical outcomes of cancer patients [ 55 , 56 ]. To evaluate immune cell infiltration in prostate cancer (PCa) patients, we employed the CIBERSORT algorithm.…”

Section: Discussionmentioning

confidence: 99%

Identification of cell differentiation trajectory-related gene signature to reveal the prognostic significance and immune landscape in prostate cancer based on multiomics analysis

Sun,

Tuo,

Chen

et al. 2024

Heliyon

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Section: Discussionmentioning

confidence: 99%

Identification of cell differentiation trajectory-related gene signature to reveal the prognostic significance and immune landscape in prostate cancer based on multiomics analysis

Sun,

Tuo,

Chen

et al. 2024

Heliyon

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“…Exposure to endocrine-disrupting chemicals, particularly phthalates, has been shown to induce immune responses that coordinate the activation of lymphocytes and monocytes in the immune and circulatory systems (Nowak et al, 2019;Pierozan et al, 2023), which may be a crucial factor in the effect of phthalates on white blood cell (WBC) counts (Xue et al, 2023). However, this hypothesis requires con rmation in future studies.…”

Section: Discussionmentioning

confidence: 99%

Exposure to phthalates and their alternatives in relation to biomarkers of inflammation and oxidative stress in adults: evidence from NHANES 2017–2018

Jin,

Cui,

et al. 2023

Environ Sci Pollut Res

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Phthalates and their alternatives are considered signi cant environmental risk factors that potentially in uence in ammation and oxidative stress. However, their impact on biomarkers of in ammation and oxidative stress was inconsistent. This study aimed to explore the associations between phthalates and high-sensitivity C-reactive protein (hsCRP), gamma-glutamyl transferase (GGT), and white blood cell (WBC) counts, employing both univariate exposure and multivariate co-exposure models. For this analysis, a total of 1619 individuals aged 18 years and above, sourced from the National Health and Nutrition Examination Survey (NHANES) conducted between 2017 and 2018, were selected as subjects. We explored the associations between hsCRP, GGT, and WBC counts and eighteen different phthalate metabolites. Multiple linear regression analysis revealed signi cant associations between hsCRP and two speci c metabolites: MCNP (β = 0.060, P = 0.034) and MEHP (β = -0.054, P = 0.049). We observed negative correlations of MCOP, MCPP, MHBP, and MONP with GGT (β = -0.036, P = 0.027; β = -0.045, P = 0.019; β = -0.046, P = 0.023; β = -0.053, P = 0.001, respectively). Conversely, MEHHP and MEHTP exhibited positive correlations with GGT (β = 0.048, P = 0.011; β = 0.029, P = 0.009). Furthermore, MECPTP and MEHTP showed positive correlations with WBC (β = 0.011, P = 0.026; β = 0.017, P = 0.001). Notably, we identi ed a non-linear relationship between phthalates and in ammation and oxidative stress markers.The Bayesian kernel machine regression (BKMR) analysis demonstrated a negative joint effect of the phthalates mixture on GGT, particularly at lower concentrations. The BKMR model also found that MEOHP and MHiBP were negatively associated with GGT. In contrast, MEHHP showed a signi cant positive association with GGT. Moderating effect analysis suggested that increased dietary in ammatory index (DII), income-to-poverty ratio (PIR), age, BMI, and less physical activity strengthened the association between phthalates and in ammation and oxidative stress. These ndings contribute to a deeper understanding of the relationships between phthalates and in ammation and oxidative stress.

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Persistent effects of di-n-butyl phthalate on liver transcriptome: Impaired energy and lipid metabolic pathways

Theodoropoulou,

Pierozan,

Marabita

et al. 2024

Chemosphere

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Persistent immunosuppressive effects of dibutyl phthalate exposure in adult male mice

Cited by 16 publications

References 75 publications

Identification of cell differentiation trajectory-related gene signature to reveal the prognostic significance and immune landscape in prostate cancer based on multiomics analysis

Identification of cell differentiation trajectory-related gene signature to reveal the prognostic significance and immune landscape in prostate cancer based on multiomics analysis

Exposure to phthalates and their alternatives in relation to biomarkers of inflammation and oxidative stress in adults: evidence from NHANES 2017–2018

Persistent effects of di-n-butyl phthalate on liver transcriptome: Impaired energy and lipid metabolic pathways

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