Persistent Impairment of Hippocampal Neurogenesis in Young Adult Rats Following Early Postnatal Alcohol Exposure

Klintsova, Anna Y.; Helfer, Jennifer L.; Calizo, Lyngine H.; Dong, Willie K.; Goodlett, Charles R.; Greenough, William T.

doi:10.1111/j.1530-0277.2007.00528.x

Cited by 146 publications

(162 citation statements)

References 84 publications

Supporting

Mentioning

137

Contrasting

Unclassified

Order By: Relevance

“…Impairment in memory (e.g., problems remembering information learned recently; repeatedly making the same mistakes; difficulty remembering long verbal instructions) 5. Impairment in visual spatial reasoning (e.g., disorganized or poorly planned drawings or constructions; problems differentiating left from right; problems aligning numbers in columns) hippocampal volume have been linked to functional memory impairments in human neuroimaging studies [41,42] and animal models [39,43]. Active working memory, which involves the capacity to store and process meaningful units at a given moment in time, has been found to be deficient in individuals with PAE, particularly for tasks involving multiple-step instructions [31].…”

Section: Memory Deficitsmentioning

confidence: 99%

Neurobehavioral Disorder Associated with Prenatal Alcohol Exposure (ND-PAE): Proposed DSM-5 Diagnosis

Kable

O’Connor

Olson

et al. 2015

Child Psychiatry Hum Dev

107

101

View full text Add to dashboard Cite

Over the past 40 years, a significant body of animal and human research has documented the teratogenic effects of prenatal alcohol exposure (PAE). Neurobehavioral Disorder associated with PAE is proposed as a new clarifying term, intended to encompass the neurodevelopmental and mental health symptoms associated with PAE. Defining this disorder is a necessary step to adequately characterize these symptoms and allow clinical assessment not possible using existing physically-based diagnostic schemes. Without appropriate diagnostic guidelines, affected individuals are frequently misdiagnosed and treated inappropriately (often to their considerable detriment) by mental health, educational, and criminal justice systems. Three core areas of deficits identified from the available research, including neurocognitive, self-regulation, and adaptive functioning impairments, are discussed and information regarding associated features and disorders, prevalence, course, familial patterns, differential diagnosis, and treatment of the proposed disorder are also provided.

show abstract

Section: Memory Deficitsmentioning

confidence: 99%

Neurobehavioral Disorder Associated with Prenatal Alcohol Exposure (ND-PAE): Proposed DSM-5 Diagnosis

Kable

O’Connor

Olson

et al. 2015

Child Psychiatry Hum Dev

107

101

View full text Add to dashboard Cite

show abstract

“…These effects are likely the direct result of cell death in the brain. Several studies have used various alcohol exposure paradigms in rodents to find that ethanol causes robust cell death in multiple brain regions during the first week of postnatal life [82][83][84][85][86]. Notably, none of these seminal studies examined alcohol-induced cell death in females.…”

Section: Alcoholmentioning

confidence: 99%

An examination of sex differences in the effects of early-life opiate and alcohol exposure

Terasaki¹,

Gomez²,

Schwarz³

2016

Phil. Trans. R. Soc. B

View full text Add to dashboard Cite

One contribution of 16 to a theme issue 'Multifaceted origins of sex differences in the brain'. Early-life exposure to drugs and alcohol is one of the most preventable causes of developmental, behavioural and learning disorders in children. Thus a significant amount of basic, animal and human research has focused on understanding the behavioural consequences and the associated neural effects of exposure to drugs and alcohol during early brain development. Despite this, much of the previous research that has been done on this topic has used predominantly male subjects or rodents. While many of the findings from these male-specific studies may ultimately apply to females, the purpose of this review is to highlight the research that has also examined sex as a factor and found striking differences between the sexes in their response to early-life opiate and alcohol exposure. Finally, we will also provide a framework for scientists interested in examining sex as a factor in future experiments that specifically examine the consequences of early-life drug and alcohol exposure.

show abstract

“…Current understanding of spatial memory deficits in children with FASDs is largely derived from an extensive animal literature showing that rats exposed to ethanol during early brain development had impaired place learning ability (Gianoulakis, 1990;Sutherland et al, 2000) and damage to the hippocampus (Klintsova et al, 2007;Livy et al, 2003), an area closely associated with spatial learning and recall and particularly vulnerable to alcohol exposure in animals and humans (Berman & Hannigan, 2000). In a study of three children who sustained early bilateral hippocampal damage due to hypoxic-ischemic brain injury, VarghaKhadem et al (1997) found significant impairments in delayed reproduction of a spatial arrangement using the Rey-Osterrieth Complex Figure task (ROCF) and poor everyday spatial memory using the parental report Everyday Memory Questionnaire (EMQ).…”

Section: Introductionmentioning

confidence: 99%

Effects of prenatal alcohol exposure on hippocampal volume, verbal learning, and verbal and spatial recall in late childhood

Willoughby

Sheard

Nash

et al. 2008

J Int Neuropsychol Soc

162

164

View full text Add to dashboard Cite

Children with prenatal alcohol exposure (PAE) show deficits in verbal learning and spatial memory, as well as abnormal hippocampal development. The relationship between their memory and neuroanatomic impairments, however, has not been directly explored. Given that the hippocampus is integral for the synthesis and retrieval of learned information and is particularly vulnerable to the teratogenic effects of alcohol, we assessed whether reduced learning and recall abilities in children with fetal alcohol spectrum disorders (FASDs) are associated with abnormal hippocampal volumes. Nineteen children with FASDs and 18 typically developing controls aged 9 to 15 years were assessed for verbal learning and verbal and spatial recall and underwent structural magnetic resonance imaging. Images were analyzed for total intracranial volume and for right and left hippocampal volumes. Results revealed smaller left hippocampi and poorer verbal learning and verbal and spatial recall performance in children with FASDs than controls, as well as positive correlations between selective memory indices and hippocampal volumes only in the FASD group. Additionally, hippocampal volumes increased significantly with age in controls only, suggesting that PAE may be associated with long-term abnormalities in hippocampal development that may contribute to impaired verbal learning and verbal and spatial recall. (JINS, 2008(JINS, , 14, 1022(JINS, -1033

show abstract

Persistent Impairment of Hippocampal Neurogenesis in Young Adult Rats Following Early Postnatal Alcohol Exposure

Abstract: These observations suggest that early postnatal binge alcohol exposure results in long-term deficits of adult hippocampal neurogenesis, providing a potential basis for the deficits of hippocampus-dependent behaviors reported for this model.

Cited by 146 publications

References 84 publications

Neurobehavioral Disorder Associated with Prenatal Alcohol Exposure (ND-PAE): Proposed DSM-5 Diagnosis

Neurobehavioral Disorder Associated with Prenatal Alcohol Exposure (ND-PAE): Proposed DSM-5 Diagnosis

An examination of sex differences in the effects of early-life opiate and alcohol exposure

Effects of prenatal alcohol exposure on hippocampal volume, verbal learning, and verbal and spatial recall in late childhood

Contact Info

Product

Resources

About