Persistent Insomnia: the Role of Objective Short Sleep Duration and Mental Health

Vgontzas, Alexandros N.; Fernández-Mendoza, Julio; Bixler, Edward O.; Singareddy, Ravi; Shaffer, Michele L.; Calhoun, Susan L.; Liao, Duanping; Basta, Maria; Chrousos, George P.

doi:10.5665/sleep.1586

Cited by 99 publications

(95 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These findings further support that objective short sleep duration is a biological marker that predicts both the severity 2 and the natural course of the disorder. 5,6 We agree with Dr Kawada 1 that the use of polysomnographic measures provides strong validity for the findings reported in our study and that future longitudinal studies using longer and multiple followups should further examine the relationship among the natural history of insomnia, objective sleep duration, and cardiovascular risk.…”

supporting

confidence: 86%

Response to Poor Sleep With Normal Sleep Duration: A Preventive Effect on Incident Hypertension

et al. 2013

Self Cite

View full text Add to dashboard Cite

supporting

confidence: 86%

Response to Poor Sleep With Normal Sleep Duration: A Preventive Effect on Incident Hypertension

et al. 2013

Self Cite

View full text Add to dashboard Cite

“…Individuals with combined insomnia and PSG-defined short sleep duration (<6 hours) have an increased risk of hypertension (Vgontzas et al, 2009a; Fernandez-Mendoza et al, 2012) and Type-2 Diabetes (Vgontzas et al, 2009b), and deficits in executive attention (Fernandez-Mendoza et al, 2010). The presence of PSG-defined short sleep duration (<6 hours) in insomnia is a strong predictor of persistent insomnia years later (Vgontzas et al, 2012). …”

Section: Discussionmentioning

confidence: 99%

Insomnia in women approaching menopause: Beyond perception

Baker

Willoughby

Sassoon

et al. 2015

Psychoneuroendocrinology

View full text Add to dashboard Cite

The menopause transition is marked by increased prevalence in disturbed sleep and insomnia, present in 40–60% of women, but evidence for a physiological basis for their sleep complaints is lacking. We aimed to quantify sleep disturbance and the underlying contribution of objective hot flashes in 72 women (age range: 43–57 years) who had (38 women), compared to those who had not (34 women), developed clinical insomnia in association with the menopause transition. Sleep quality was assessed with two weeks of sleep diaries and one laboratory polysomnographic (PSG) recording. In multiple regression models controlling for menopause transition stage, menstrual cycle phase, depression symptoms, and presence of objective hot flashes, a diagnosis of insomnia predicted PSG-measured total sleep time (p<0.01), sleep efficiency (p=0.01) and wakefulness after sleep onset (WASO) (p=0.01). Women with insomnia had, on average, 43.5 minutes less PSG-measured sleep time (p<0.001). There was little evidence of cortical EEG hyperarousal in insomniacs apart from elevated beta EEG power during REM sleep. Estradiol and follicle stimulating hormone levels were unrelated to beta EEG power but were associated with the frequency of hot flashes. Insomniacs were more likely to have physiological hot flashes, and the presence of hot flashes predicted the number of PSG-awakenings per hour of sleep (p=0.03). From diaries, women with insomnia reported more WASO (p=0.002), more night-to-night variability in WASO (p<0.002) and more hot flashes (p=0.012) compared with controls. Women who develop insomnia in the approach to menopause have a measurable sleep deficit, with almost 50% of the sample having less than 6 hours of sleep. Compromised sleep that develops in the context of the menopause transition should be addressed, taking into account unique aspects of menopause like hot flashes, to avoid the known negative health consequences associated with insufficient sleep and insomnia in midlife women.

show abstract

“…Short sleep is also recognized to have an adverse effect on hypertension, diabetes, and cardiovascular disease in addition to adverse effects on mental health, including stress, depression or suicide (Cappuccio et al 2011;Kohyama 2011;Vgontzas et al 2012;Gangwisch 2014;Shan et al 2015). Moreover, a prospective cohort study showed that lack of physical activity was linked to worse mental health, with participation in physical activity reported to improve the symptoms of depression (Mammen and Faulkner 2013;Kuwahara et al 2015).…”

Section: Introductionmentioning

confidence: 99%

Sedentary Behavior and Sleep Duration Are Associated with Both Stress Symptoms and Suicidal Thoughts in Korean Adults

Jang

Kim

2015

Tohoku J. Exp. Med.

View full text Add to dashboard Cite

Prolonged sedentary time and sleep deprivation are associated with mental health problems such as depression and stress symptoms. Moreover, mental illness is linked with suicidal thoughts and suicide attempts. However, it is not clear whether sedentary time and sleep duration are associated with stress symptoms and suicidal thoughts independent of physical activity. Thus, our study aimed to identify if sedentary time and sleep duration were associated with both stress symptoms and suicidal thoughts. The participants in present cross-sectional study were 4,674 general Korean adults (1,938 male; 2,736 female), aged ≥ 20 years. Prolonged sedentary time (≥ 420 min/day) was significantly associated with the increased risk of stress symptoms (OR, 1.30; 95% CI, 1.04-1.62) compared with sedentary time of < 240 min/day. The OR for stress symptoms was significant for individuals who had ≤ 5 h/day of sleep time (OR, 1.88; 95% CI, 1.48-2.38) compared with sleep duration of ≥ 7 h/day. Moreover, prolonged sedentary time (OR, 1.55; 95% CI, 1.01-2.42 in ≥ 420 min/day vs. < 240 min/day) and short sleep duration (OR, 1.75; 95% CI, 1.17-2.62 in ≤ 5 h/day vs. ≥ 7 h/day) were significantly associated with an increased risk for suicidal thoughts after adjusting for confounding factors including physical activity. Thus, prolonged sedentary time and sleep deprivation are independently associated with both the risk of stress symptoms and suicidal thoughts. From a public health perspective, reducing sedentary time and improvement of sleep deprivation may serve as an effective strategy for preventing mental illness.

show abstract

Persistent Insomnia: the Role of Objective Short Sleep Duration and Mental Health

Abstract: Objective short sleep duration and mental health problems are the strongest predictors of persistent insomnia. These data further support the validity and clinical utility of objective short sleep duration as a novel marker of the biological severity of insomnia.

Cited by 99 publications

References 35 publications

Response to Poor Sleep With Normal Sleep Duration: A Preventive Effect on Incident Hypertension

Response to Poor Sleep With Normal Sleep Duration: A Preventive Effect on Incident Hypertension

Insomnia in women approaching menopause: Beyond perception

Sedentary Behavior and Sleep Duration Are Associated with Both Stress Symptoms and Suicidal Thoughts in Korean Adults

Contact Info

Product

Resources

About