Persistent interferon‐β‐1b‐induced psychosis in a patient with multiple sclerosis

Manfredi, Giovanni; Kotzalidis, Georgios D.; Sani, Gabriele; Koukopoulos, Alexia E.; Savoja, Valeria; Lazanio, Simone; Girardi, Nicoletta; Tatarelli, Roberto

doi:10.1111/j.1440-1819.2010.02122.x

Cited by 17 publications

(8 citation statements)

References 15 publications

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“…In addition, some of the medical treatments that have been proposed for COVID-19 could contribute to onset or worsening of psychiatric symptoms. These include psychiatric disturbances with antivirals and steroids as well as depressive-dysphoric experiences with interferons (Tamam et al, 2003;Warrington and Bostwick, 2006;Manfredi et al, 2010;Kenna et al, 2011).…”

Section: Consequences Of Lockdown and Other Measures To Prevent And Tmentioning

confidence: 99%

Response to the Novel Corona Virus (COVID-19) Pandemic Across Africa: Successes, Challenges, and Implications for the Future

Ogunleye

Basu

Mueller³

et al. 2020

Front. Pharmacol.

176

215

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Background: The COVID-19 pandemic has already claimed considerable lives. There are major concerns in Africa due to existing high prevalence rates for both infectious and non-infectious diseases and limited resources in terms of personnel, beds and equipment. Alongside this, concerns that lockdown and other measures will have on prevention and management of other infectious diseases and non-communicable diseases (NCDs). NCDs are an increasing issue with rising morbidity and mortality rates. The World Health Organization (WHO) warns that a lack of nets and treatment could result in up to 18 million additional cases of malaria and up to 30,000 additional deaths in sub-Saharan Africa. Objective: Document current prevalence and mortality rates from COVID-19 alongside economic and other measures to reduce its spread and impact across Africa. In addition, suggested ways forward among all key stakeholder groups. Our Approach: Contextualise the findings from a wide range of publications including internet-based publications coupled with input from senior-level personnel. Ongoing Activities: Prevalence and mortality rates are currently lower in Africa than among several Western countries and the USA. This could be due to a number of factors including early instigation of lockdown and border closures, the younger age of the population, lack of robust reporting systems and as yet unidentified genetic and other factors. Innovation is accelerating to address concerns with available equipment. There are ongoing steps to address the level of misinformation and its consequences including fines. There are also ongoing initiatives across Africa to start addressing the unintended consequences of COVID-19 activities including lockdown measures and their impact on Ogunleye et al. COVID-19 in Africa NCDs including the likely rise in mental health disorders, exacerbated by increasing stigma associated with COVID-19. Strategies include extending prescription lengths, telemedicine and encouraging vaccination. However, these need to be accelerated to prevent increased morbidity and mortality. Conclusion: There are multiple activities across Africa to reduce the spread of COVID-19 and address misinformation, which can have catastrophic consequences, assisted by the WHO and others, which appear to be working in a number of countries. Research is ongoing to clarify the unintended consequences given ongoing concerns to guide future activities. Countries are learning from each other.

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Section: Consequences Of Lockdown and Other Measures To Prevent And Tmentioning

confidence: 99%

Response to the Novel Corona Virus (COVID-19) Pandemic Across Africa: Successes, Challenges, and Implications for the Future

Ogunleye

Basu

Mueller³

et al. 2020

Front. Pharmacol.

176

215

View full text Add to dashboard Cite

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“…The initial presentation of BD may include a depressive phase, or a manic-phase with or without psychotic symptoms. All of these presentations have been temporally associated with MS (13–17) and pharmacological treatments of MS (18, 19), making expeditious and confident diagnosis perilous. It remains unclear to what degree and how consistent bipolar disorder is as a prodromal feature of MS.…”

Section: Introductionmentioning

confidence: 99%

The Prevalence of Bipolar Disorders and Association With Quality of Life in a Cohort of Patients With Multiple Sclerosis

Jun-O’Connell¹,

Butala²,

Morales³

et al. 2017

JNP

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Clinical observations of mood instability in multiple sclerosis (MS) have led to the hypothesis that bipolar disorder (BD) may be more prevalent in persons with MS than in the general population. This cross-sectional study assesses the prevalence of BD among patients with MS using standardized psychiatric diagnostic interviews, and evaluates quality of life. This study demonstrates a higher prevalence of BD in patients with MS compared to the general population. It also shows the negative impact of BD on quality of life, raises the concern that BD can occur before the onset of neurological symptoms in MS, and reveals how BD may delay diagnosis of MS in patients.

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“…There is also a case report of persistent psychosis due to interferon-β-1b in a patient with MS (Manfredi et al, 2010). However, to the best of our knowledge there are no reported cases with natalizumab, and it is unlikely that this medication caused the auditory phenomenon because cessation for a few months did not abate the symptoms.…”

Section: Discussionmentioning

confidence: 81%

Recurrent refrains in a patient with multiple sclerosis: Earworms or musical hallucinations?

Husain

Levin

Scott

et al. 2014

Multiple Sclerosis and Related Disorders

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Musical hallucinations are recognized in certain neurological and psychiatric conditions and can be caused by focal brain disease (Evers and Ellger, 2004). However, the occurrence of primary musical hallucinations in multiple sclerosis (MS) has not been reported previously. We report a case of a 54 year old woman with progressive, relapsing MS who has continuous, unremitting, complex auditory phenomenon for an extended period of time. We believe that MS lesions rather than medications are the cause for this disturbing symptom and we present a brief review of the literature regarding the current views on the neural substrates of musical perception and cognition.

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Persistent interferon‐β‐1b‐induced psychosis in a patient with multiple sclerosis

Cited by 17 publications

References 15 publications

Response to the Novel Corona Virus (COVID-19) Pandemic Across Africa: Successes, Challenges, and Implications for the Future

Response to the Novel Corona Virus (COVID-19) Pandemic Across Africa: Successes, Challenges, and Implications for the Future

The Prevalence of Bipolar Disorders and Association With Quality of Life in a Cohort of Patients With Multiple Sclerosis

Recurrent refrains in a patient with multiple sclerosis: Earworms or musical hallucinations?

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