Persistent organic pollutants in foods, their interplay with gut microbiota and resultant toxicity

Popli, Shivani; Badgujar, Prarabdh C.; Agarwal, Tripti; Bhushan, Bharat; Mishra, Vijendra

doi:10.1016/j.scitotenv.2022.155084

Cited by 40 publications

(13 citation statements)

References 121 publications

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“…Al mismo tiempo, algunos productos químicos, como el el diclorodifenildicloroetileno, tienen el potencial de elevar la proporción de proteobacterias y firmicutes/bacteriodetes, lo que influye en su actividad metabólica, y ello conduce a una mayor síntesis de ácidos grasos de cadena corta, con la consiguiente obesidad o un estado prediabético. Se destaca el impacto de la exposición a los COP en la composición de la microbiota intestinal y la actividad metabólica, junto con una descripción de sus correspondientes consecuencias en la fisiología del huésped (Popli et al, 2022).…”

Section: Los Contaminantes Orgánicos Persistentes Y Su Impacto En La ...unclassified

Contaminantes orgánicos persistentes: Impactos y medidas de control

Castro López,

Castillo Rodríguez

2024

Manglar

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Persistent organic pollutants (POPs) represent a significant environmental problem due to their toxicity, with a high capacity to persist in the environment, resistance to conventional degradation methods, the ability to accumulate in living organisms and their magnification in food chains or food. In this review article, the impacts on health and environmental components are examined. Strategies and measures for control, mitigation and/or minimization of POPs are also addressed. Agricultural and industrial activities, inadequate final disposal of solid waste and lack of wastewater treatment are identified as the main sources of POP emissions. In addition, innovative and promising technologies are analyzed, such as nanotechnology, bioremediation, rhizoremediation, biochar, chromatography techniques, ultrasound, among others, for the adequate treatment of POPs. The review highlights both the advantages and limitations of these technologies, pointing out areas that still require developments to achieve effective treatments. More economical and ecological alternatives are also mentioned to counteract the impacts of POPs.

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Section: Los Contaminantes Orgánicos Persistentes Y Su Impacto En La ...unclassified

Contaminantes orgánicos persistentes: Impactos y medidas de control

Castro López,

Castillo Rodríguez

2024

Manglar

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“…Gut microbiota can come in contact with ingested foods contaminated with toxic chemicals, which include persistent organic pollutants (polychlorinated biphenyls, polybrominated diphenyl ethers) [ 274 ] or pesticides [ 275 , 276 ]. These molecules can induce gut dysbiosis which, in turn, can predispose to altered metabolic homeostasis and obesity.…”

Section: The Modulation Of Gut Microbiota-fat Axis By External Factorsmentioning

confidence: 99%

Contribution of the microbiome for better phenotyping of people living with obesity

Ciaula

Bonfrate

Khalil

et al. 2023

Rev Endocr Metab Disord

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Obesity has reached epidemic proportion worldwide and in all ages. Available evidence points to a multifactorial pathogenesis involving gene predisposition and environmental factors. Gut microbiota plays a critical role as a major interface between external factors, i.e., diet, lifestyle, toxic chemicals, and internal mechanisms regulating energy and metabolic homeostasis, fat production and storage. A shift in microbiota composition is linked with overweight and obesity, with pathogenic mechanisms involving bacterial products and metabolites (mainly endocannabinoid-related mediators, short-chain fatty acids, bile acids, catabolites of tryptophan, lipopolysaccharides) and subsequent alterations in gut barrier, altered metabolic homeostasis, insulin resistance and chronic, low-grade inflammation. Although animal studies point to the links between an “obesogenic” microbiota and the development of different obesity phenotypes, the translational value of these results in humans is still limited by the heterogeneity among studies, the high variation of gut microbiota over time and the lack of robust longitudinal studies adequately considering inter-individual confounders. Nevertheless, available evidence underscores the existence of several genera predisposing to obesity or, conversely, to lean and metabolically health phenotype (e.g., Akkermansia muciniphila , species from genera Faecalibacterium , Alistipes , Roseburia ). Further longitudinal studies using metagenomics, transcriptomics, proteomics, and metabolomics with exact characterization of confounders are needed in this field. Results must confirm that distinct genera and specific microbial-derived metabolites represent effective and precision interventions against overweight and obesity in the long-term.

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“…Thus, in this study, the administration of DDT to mice during pregnancy produced a reduction in body tem- Today it is known that the composition of the intestinal microbiota plays a key role in the development of obesity. In this context, ingested organochlorines can modify the composition thereof, generating dysbiosis (Popli et al, 2022). Thus, it has been observed that chronic exposure of adult mice to a low dose of DDE for 8 weeks influences the relative composition and diversity of the intestinal microbiota, and alters bile acid metabolism (Liu et al, 2017).…”

Section: Scientific Evidencementioning

confidence: 99%

Report of the Scientific Committee of the Spanish Agency for Food Safety and Nutrition (AESAN) on the available evidence in relation to the potential obesogenic activity of certain chemical compounds that may be present in foods

Velasco,

Lesmes,

Perales

et al. 2023

EFS4

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Persistent organic pollutants in foods, their interplay with gut microbiota and resultant toxicity

Cited by 40 publications

References 121 publications

Contaminantes orgánicos persistentes: Impactos y medidas de control

Contaminantes orgánicos persistentes: Impactos y medidas de control

Contribution of the microbiome for better phenotyping of people living with obesity

Report of the Scientific Committee of the Spanish Agency for Food Safety and Nutrition (AESAN) on the available evidence in relation to the potential obesogenic activity of certain chemical compounds that may be present in foods

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