“…[12][13][14] Thus, buprenorphine recipients report far higher rates of chronic pain than the 10 % prevalence estimated in the general US population by the World Health Organization. 15,16 Heterogeneous clinical conditions account for the sites of pain-low back, legs, total body-that comprise the majority of pain complaints among opioid-dependent patients. 6,17 Pain in this population has been attributed to past traumatic injuries, chronic medical conditions, human immunodeficiency virus and hepatitis C virus infection, 18,19 opioid-induced hyperalgesia, 20 and non-specific factors unrelated to opioid withdrawal.…”