Persistent Palatal Ulcerations. A Potential Manifestation of Juvenile Systemic Lupus Erythematosus

Katz, Joel T.; Islam, M N; Cha, Seung-Hoon; Saleh, Wafa Elgeadi; Guelmann, Márcio

doi:10.17796/1053-4625-44.1.9

Cited by 2 publications

(2 citation statements)

References 5 publications

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“…A nationwide population-based study in Korea has demonstrated that oral ulcers were associated with an increased risk of systemic autoimmune diseases including SLE, and this study indicated that oral ulcers could be an early manifestation of systemic autoimmune disease [ 25 ]. Meanwhile, persistent palatal ulcerations could be a potential sign of SLE in adolescents [ 26 ]. We identified that the incidence of LMV in SLE patients with oral ulcers was four times those without oral ulcers.…”

Section: Discussionmentioning

confidence: 99%

Clinico-Laboratory Features and Associated Factors of Lupus Mesenteric Vasculitis

et al. 2021

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Introduction: Lupus mesenteric vasculitis (LMV) is a rare but potentially life-threatening clinical entity in systemic lupus erythematosus (SLE) patients. Objective: The present study was initiated to explore the clinical features and associated factors of LMV in SLE patients. Methods: We conducted a retrospective study on 50 cases of SLE patients with lupus mesenteric vasculitis (LMV) from January 2010 to December 2019 and 89 cases of non-LMV-SLE patients with similar demographic and comorbidities were included as control. All the data regarding clinical features, laboratory findings, and treatment were reviewed independently by two experts in the field. Both univariate and multivariate logistic regression analyses were employed to identify the associated factors of LMV. Results: The incidence of LMV was 2.9% among hospitalized SLE patients in the current study. The most frequent symptom and physical sign of LMV were respectively abdominal pain (48, 96%) and abdominal tenderness (45, 90%). Through univariate and subsequent multivariate analysis, oral ulcer (OR, 4.25; P = 0.024), urinary tract involvement (OR, 5.23; P = 0.021), and elevated D-dimer (OR, 1.121; P = 0.008) were demonstrated to be positively associated with LMV, while percentage of lymphocytes (OR, 0.928; P = 0.004) and complement 3 (OR, 0.048; P = 0.008) were negatively correlated with LMV. Conclusions: Oral ulcer, urinary tract involvement, reduced percentage of lymphocytes and complement 3, elevated D-dimer could be associated factors for LMV in SLE patients.

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Section: Discussionmentioning

confidence: 99%

Clinico-Laboratory Features and Associated Factors of Lupus Mesenteric Vasculitis

et al. 2021

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“…Furthermore, different geographical regions of the world affecting various ethnic backgrounds and both sexes showed variable clinical features 2. Only minor portion of SLE cases form Juvenile SLE (10-20%) that affect any organ system. Disease pattern is variable from mild to frequent flares requiring long term immunosuppressive therapy leading to considerable organ damage that depends on disease duration and time of onset 3,4 .…”

Section: Introductionmentioning

confidence: 99%

Clinical and Immunological Profile of Childhood Systemic Lupus Erythematosus: Observational Study

Qamar¹,

Naz²,

Batool³

et al. 2022

PJMHS

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Background: Childhood SLE is a severe autoimmune disease involving multiple systems that effect peoples globally. Aim: To delineate the spectrum of clinical manifestations of childhood SLE at the Government Children’s Hospital Lahore. Study design: Descriptive observational study. Methodology: Study was carried out at department of Pediatric medicine, unit 1, Children’s hospital Lahore from January 2016 to December 2019. Applying a nonprobability convenience sampling technique, children between 1-16 years of age with childhood systemic lupus erythematosus attending rheumatology outpatient clinic or admitted through emergency were included in study. Written and verbal informed consent was obtained after explanation of study purpose. Results: There were 59 (78.70%) female and 16 (28.3%) male patients enrolled in the study. Mean age at diagnosis was 10.89±3.4% years. Female predominance was noticeable. Amongst the clinical features fever (96%) was the commonest, followed by oral ulcers (74.70%), alopecia (72%), renal manifestations (69.30%), rash (61.30%), arthritis (56%), and hematological abnormalities (48%), photosensitivity (44%), neurological features (36%) in 24% of patients. Conclusion: It was concluded that disease was prevalent among all races around the world but in South Asia there are few studies available on its prevalence. Timely diagnosis by a detailed history, physical examination and laboratory evaluation can improve the chances of prolonged disease-free periods and better survival of children. Keywords: Childhood SLE, ACR and SLICC.

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Persistent Palatal Ulcerations. A Potential Manifestation of Juvenile Systemic Lupus Erythematosus

Cited by 2 publications

References 5 publications

Clinico-Laboratory Features and Associated Factors of Lupus Mesenteric Vasculitis

Clinico-Laboratory Features and Associated Factors of Lupus Mesenteric Vasculitis

Clinical and Immunological Profile of Childhood Systemic Lupus Erythematosus: Observational Study

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