Persistent Pregnancy-Related Anxiety Reduces Breastfeeding Exclusiveness and Duration: A Prospective Cohort Study

Shao, Shanshan; Yan, Shuangqin; Zhu, Peng; Hao, Jiahu; Zhu, Beibei; Tao, Fangbiao

doi:10.1089/bfm.2021.0346

Cited by 9 publications

(4 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We add to the literature [39] by showing similar findings in pregnancy-related anxiety, a special mode of prenatal stress that has received little attention but predicts fetal development outcomes more accurately than general anxiety and depression symptoms [40,41]. Compared with our two previous works [7,8], the present study found similar gender-dependent outcomes but only focused on pregnancy-related anxiety at the third trimester because this cohort data showed that the third trimester is the critical period of pregnancy-related anxiety on child neurobehavioral development [42]. All the three works [7,8] reported the male-bias hyperactivity symptoms but only two works [8] reported the femalebias emotional symptoms.…”

Section: Discussionsupporting

confidence: 76%

Gender-specific associations of pregnancy-related anxiety with placental epigenetic patterning of glucocorticoid response genes and preschooler’s emotional symptoms and hyperactivity

Liu

Huang

et al. 2021

BMC Pediatr

View full text Add to dashboard Cite

Backgroud We have recently reported that maternal prenatal pregnancy-related anxiety predicts preschoolers’ emotional and behavioral development in a gender-dependent manner. This study aims to test for this gender-specific effect in a different cohort and investigate whether the gender difference was specific to placental methylation of genes regulating glucocorticoids. Methods A total of 2405 mother–child pairs from the Ma’anshan Birth Cohort Study were included in present study. The maternal pregnancy-related anxiety symptoms were evaluated with the Pregnancy-Related Anxiety Questionnaire in the third trimester of pregnancy. Child neurobehavior was assessed with the Strengths and Difficulties Questionnaire at 4 years old. Placental methylation of FKBP5, NR3C1 and HSD11B2 genes was quantified using the MethylTarget approach in 439 pregnant women. After exploratory factor analysis, the associations between methylation factor scores and pregnancy-related anxiety and child neurobehavior were examined using logistic regression analysis. Results After controlling for confounding factors, pregnancy-related anxiety in the third trimester of pregnancy increased the risk of hyperactivity only in boys and emotional symptoms only in girls. Decreased scores of the factor characterized by FKBP5 methylation were associated with maternal pregnancy-related anxiety only in boys. Furthermore, increased scores of the factors characterized by NR3C1 and HSD11B2 methylation were associated with hyperactivity (NR3C1: adjusted OR = 1.80, 95%CI = 1.15–2.83) and emotional symptoms (HSD11B2: adjusted OR = 0.53, 95%CI = 0.29–0.97; NR3C1: adjusted OR = 1.64, 95%CI = 1.03–2.59) only in boys. However, the scores of the factor characterized by FKBP5, NR3C1 and HSD11B2 did not mediate the relationship between maternal pregnancy-related anxiety and preschoolers’ emotional symptoms and hyperactivity. Conclusions Our results suggested that pregnancy-related anxiety in the third trimester of pregnancy predicted preschoolers’ emotional symptoms and hyperactivity in a gender-dependent manner. Although we did not find the mediation role of the placental methylation of genes regulating glucocorticoids, we found it was associated with both maternal pregnancy-related anxiety and preschoolers’ emotional symptoms and hyperactivity in a gender-dependent manner.

show abstract

Section: Discussionsupporting

confidence: 76%

Gender-specific associations of pregnancy-related anxiety with placental epigenetic patterning of glucocorticoid response genes and preschooler’s emotional symptoms and hyperactivity

Liu

Huang

et al. 2021

BMC Pediatr

View full text Add to dashboard Cite

show abstract

“…Additionally, higher levels of depressive and anxiety symptoms in mothers who are not breastfeeding have been reported, 63,64 whereby using baby formula milk may be a predictor of these symptoms. Interestingly, we observed that living near to chemistry laboratory or factory did not increase the risk for MIH, and a possible explanation is that in the locality there are very few and usually small factories or laboratories, which may not produce a large amount of waste reducing their pollution.…”

Section: Discussionmentioning

confidence: 99%

Association between psychological factors and molar–incisor hypomineralization: A cross‐sectional study

Mafla,

Orozco‐Tovar,

Ortiz‐Gómez

et al. 2023

Int J Paed Dentistry

View full text Add to dashboard Cite

BackgroundMolar–incisor hypomineralization (MIH) is a developmental enamel defect characterized by opacities from white to brownish color. A suspected multifactorial etiology has been suggested, whereas psychological factors during pregnancy have only been limitedly analyzed.AimWe assessed the association between stress, depression, and anxiety in pregnancy and the presence of MIH in children at a later age.DesignUsing a cross‐sectional Web‐based questionnaire, we included 384 mothers who had children aged 6 and 12 years from Pasto, Colombia. Data were collected between October 2021 and March 2022. Sociodemographic variables; maternal and child factors related to prenatal, natal, or postnatal problems; and psychological factors such as stress and symptoms of anxiety and depression in pregnancy were inquired. Utilizing photographs depicting MIH lesions, mothers assessed their child's MIH status. A directed acyclic graph (DAG) analysis was performed to create causal assumptions, and logistic regression models were estimated to evaluate these assumptions. p‐value was set at p < .05.ResultsThe prevalence of MIH was 33.3%; 12.8% of the participants exhibited hypomineralization in both molars and incisors. DAG analysis and logistic regression models determined that MIH (present or not) was associated with symptoms of maternal depression (ORadj = 3.26, 95% CI: 1.92–5.52, p < .001), and MIH (both molars and incisors) was associated with symptoms of maternal anxiety (ORadj = 3.49, 95% CI: 1.80–6.76, p < .001).ConclusionPsychological factors, among others, were significantly associated with the presence of MIH.

show abstract

“…More broadly, studies conducted prior to the pandemic have established links between perinatal distress and poorer child outcomes including worse cognitive performance (Glover, 2015), psychiatric disorders (Bale et al, 2010;Van den Bergh et al, 2020), and more socioemotional (Porter et al, 2019) and behavioral (Kingston & Tough, 2014) problems. Pregnancy-related anxiety (i.e., speci c anxiety about the emotions, thoughts, and physical symptoms experienced by pregnant individuals; Bayrampour et al, 2016), has also been uniquely linked to negative developmental outcomes in offspring, including developmental delays (Shao et al, 2021) and risk for emotional and behavioral problems (Wang et al, 2021). Thus, heightened prenatal pandemic-related anxiety may also signal risk for poorer developmental outcomes in children, although studies have yet to examine such associations within a prospective framework.…”

Section: Introductionmentioning

confidence: 99%

The Influence of Pandemic-Related Worries During Pregnancy on Child Development at 12 Months

White,

Himes,

Waller

et al. 2023

Child Psychiatry Hum Dev

View full text Add to dashboard Cite

The COVID-19 pandemic has been linked to increased risk for perinatal anxiety and depression among parents, as well as negative consequences for child development. Less is known about how worries arising from the pandemic during pregnancy are related to later child development, nor if resilience factors buffer negative consequences. The current study addresses this question in a prospective longitudinal design. Data was collected from a sub-study (n = 184) of a longitudinal study of pregnant individuals (total n = 1,173). During pregnancy (April 17-July 8, 2020) and the early postpartum period (August 11, 2020-March 2, 2021), participants completed online surveys. At 12 months postpartum (June 17, 2021-March 23, 2022, participants completed online surveys and a virtual laboratory visit, which included parent-child interaction tasks. We found more pregnancy-speci c pandemic worries were prospectively related to lower levels of child socioemotional development based on parent report (B=-1.13, SE = .43, p = .007) and observer ratings (B=-0.13, SE = .07, p = .045), but not to parent-reported general developmental milestones. Parental emotion regulation in the early postpartum period moderated the association between pregnancyspeci c pandemic worries and child socioemotional development such that pregnancy-speci c pandemic worries did not related to worse child socioemotional development among parents with high (B=-.02, SE = .10, t=-.14, p = .89) levels of emotion regulation. Findings suggest the negative consequences of parental worry and distress during pregnancy on the early socioemotional development of children in the context of the COVID-19 pandemic. Results highlight that parental emotion regulation may represent a target for intervention to promote parental resilience and support optimized child development.

show abstract

Persistent Pregnancy-Related Anxiety Reduces Breastfeeding Exclusiveness and Duration: A Prospective Cohort Study

Cited by 9 publications

References 33 publications

Gender-specific associations of pregnancy-related anxiety with placental epigenetic patterning of glucocorticoid response genes and preschooler’s emotional symptoms and hyperactivity

Gender-specific associations of pregnancy-related anxiety with placental epigenetic patterning of glucocorticoid response genes and preschooler’s emotional symptoms and hyperactivity

Association between psychological factors and molar–incisor hypomineralization: A cross‐sectional study

The Influence of Pandemic-Related Worries During Pregnancy on Child Development at 12 Months

Contact Info

Product

Resources

About