Persistent Subacute Thyroiditis Post SARS-CoV-2 Vaccine in a Male Patient with Positive Thyroid Autoantibodies

Topaloğlu, Ömercan; Tekin, Sakin; Topaloğlu, Seda Nur; Bayraktaroğlu, Taner

doi:10.25179/tjem.2021-86594

Cited by 4 publications

(14 citation statements)

References 17 publications

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“…Topaloğlu et al had described persistent subacute thyroiditis, which started after the first and also second doses of CoronaVac vaccine in the same patient. They also suggested similar mechanisms to ASIA [19] mRNA vaccines such as Pfizer-BioNTech containing synthetic mRNA sequences that encode the spike protein of Sars-CoV-2. The mRNA in this vaccine is considered self-adjuvant due to its ability to act as both antigen and adjuvant and its capacity to directly stimulate innate immunity [20].…”

Section: Discussionmentioning

confidence: 92%

“…They also suggested similar mechanisms to ASIA. (19) mRNA vaccines such as Pfizer-BioNTech® contain synthetic mRNA sequences that encode the spike protein of Sars-CoV-2. The mRNA in this vaccine is considered selfadjuvant due to its ability to act as both antigen and adjuvant and its capacity to directly stimulate innate immunity.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

“…It has been shown that the SARS-CoV-2 spike protein, nucleoprotein, and membrane protein cross-react with thyroid peroxidase, and the thyroid peroxidase peptide sequence is the same or similar to the sequences in SARS-CoV-2 proteins. [19,24] This homology with human proteins can induce innate immunity after vaccination, resulting in an autoimmune or inflammatory process in which the body targets its own proteins. [25] Therefore, it is possible that mRNA vaccines encoding the SARS-CoV-2 spike protein may trigger autoimmune diseases by inducing innate immunity.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

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Subacute Thyroiditis Following SARS-CoV-2 Vaccines: Six Cases Report and Review of the Literature

Kurtulmuş

Kayikci

2022

Horm Metab Res

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Subacute thyroiditis(SAT) is an inflammatory disease of the thyroid that develops following viral upper respiratory tract infections. SARS-CoV-2 virus, the cause of COVID-19, binds to the Angiotensin-Converting Enzyme-2 (ACE2) molecule expressed on the target cell surface.Thyroid gland shows high levels of ACE2 expression. The cases of SARS-CoV-2-related subacute thyroiditis and Graves' disease have been reported. It has recently been noted that vaccines for SARS-CoV-2 also induce autoimmune and inflammatory reactions. We present six (4 male, 2 female) cases of SAT that developed after mRNA and inactivated SARS-CoV-2 vaccines. And we reviewed literature.SAT was seen in 5 patients after mRNA vaccine, in one after inactivated vaccine.Their clinic and laboratory findings suggested to SAT. They were treated with nonsteroid antiinflamatory drugs and/or methylprednisolone.They recovered within few weeks.Out patients didn’t have permanent hypothyroidism after SAT. The history of SARS-CoV-2 vaccination should be questioned in patients with subacute thyroiditis in pandemic days.

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Section: Discussionmentioning

confidence: 92%

Section: Accepted Manuscriptmentioning

confidence: 99%

Section: Accepted Manuscriptmentioning

confidence: 99%

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Subacute Thyroiditis Following SARS-CoV-2 Vaccines: Six Cases Report and Review of the Literature

Kurtulmuş

Kayikci

2022

Horm Metab Res

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“…We previously reported a case of persistent SAT associated with CoronaVac who did not have prominent elevations in ESR or CRP [21]. In that case, ESR was elevated at the 1 st referral of the patient after the 1 st dose of CoronaVac, but CRP was elevated especially in the 2 nd referral (persistence) after the 2 nd dose of the vaccine [21]. Actually, in the present study, we did measure ESR and CRP but failed to measure the other indicators of acute phase response such as interleukin-1, interferon-gamma, tumor necrosis factor-alpha, complement components, or fibrinogen.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

“…Vaccination against COVID-19 has been continued since January 2021, in our country, Türkiye, by mRNA (BioNTech®) and inactive (CoronaVac®) vaccines [18]. A lot of cases of SAT developed after the COVID-19 vaccination have been observed and reported worldwide and from Türkiye [19][20][21][22][23].…”

Section: Introductionmentioning

confidence: 99%

Differences in Clinical Aspects Between Subacute Thyroiditis Associated with COVID-19 Vaccines and Classical Subacute Thyroiditis

et al. 2022

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Subacute thyroiditis(SAT) developed after SARS-CoV-2 vaccines has been less studied. We aimed to compare classical SAT and SAT developed after SARS-CoV-2 vaccines in the context of clinical aspects. Adults with SAT detected in 90 days of COVID-19 vaccination (CoronaVac® or Pfizer/BioNTech®) were grouped as Vac-SAT (CoronaVac-SAT and BioNTech-SAT). Those with a history of SARS-CoV-2 or upper respiratory tract infection in 6 months before the vaccination, or vaccination with another antiviral vaccine after COVID-19 vaccination were excluded. Those with SAT detected before COVID-19 pandemic were grouped as Classical-SAT. Of total(n=85), female/male(54/31) ratio and age(43(23-65)) were similar in Vac-SAT(n=23) and Classical-SAT(n=62) groups. Duration between vaccine and SAT was 45(7-90) days, and similar in CoronaVac-SAT(n=5) and BioNTech-SAT(n=18) groups. SAT-duration was 28(10-150) days, and higher in Vac-SAT than in Classical-SAT group(p=0.023). SAT was developed after the 1st dose vaccine in minority in CoronaVac-SAT(n=2) and BioNTech-SAT(n=3) groups(p=0.263). Previous LT4 use, and TSH elevation after resolution were more frequent in Vac-SAT than in Classical-SAT(p=0.027 and p=0.041, respectively). We included a considerable number of patients with SAT occurred after COVID-19 vaccines. We cannot provide clear evidence regarding the association of COVID-19 vaccines with SAT. SAT associated with CoronaVac® or BioNTech® seems unlikely to be occurred after the 1st dose, and to have a longer duration, more likely to be associated with previous LT4 use and lead TSH elevation after resolution than Classical-SAT. TSH should be followed-up after the resolution of SAT detected after COVID-19 vaccination.

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SARS-CoV-2 vaccine inactivated Sinovac Biotech

2022

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Persistent Subacute Thyroiditis Post SARS-CoV-2 Vaccine in a Male Patient with Positive Thyroid Autoantibodies

Cited by 4 publications

References 17 publications

Subacute Thyroiditis Following SARS-CoV-2 Vaccines: Six Cases Report and Review of the Literature

Subacute Thyroiditis Following SARS-CoV-2 Vaccines: Six Cases Report and Review of the Literature

Differences in Clinical Aspects Between Subacute Thyroiditis Associated with COVID-19 Vaccines and Classical Subacute Thyroiditis

SARS-CoV-2 vaccine inactivated Sinovac Biotech

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