Persistent symptoms in patients with Crohn’s disease in remission: An exploratory study on the role of diet

Komperød, Maren Jeanette; Sommer, Christine; Mellin-Olsen, Tonje; Iversen, Per Ole; Røseth, Arne; Valeur, Jørgen

doi:10.1080/00365521.2017.1397736

Cited by 16 publications

(9 citation statements)

References 22 publications

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“…While the success of available exclusion diets is limited, we may be overlooking the potential of an antigen-response based exclusion diet. Patients with IBD have been shown to have significantly higher rates of food hypersensitivity (allergies and intolerances), and encouraging results have been observed in response to IgG or IgE-titre based exclusion diets [ 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 ]. Further research in this area using objective measures of disease activity is needed to determine if the intake of specific dietary antigens correlates directly with IBD symptoms.…”

Section: Discussionmentioning

confidence: 99%

Inflammatory Bowel Disease: Are Symptoms and Diet Linked?

et al. 2020

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New Zealand (NZ) has one of the world’s highest incidence rates of Inflammatory Bowel Disease (IBD), a group of chronic inflammatory conditions that affect the gastrointestinal tract. Patients with IBD often believe certain foods influence their disease symptoms and consequently may alter their diet considerably. The objective of this study was to determine foods, additives, and cooking methods (dietary elements) that NZ IBD patients identify in the onset, exacerbation, or reduction of their symptoms. A total of 233 participants completed a self-administered questionnaire concerning symptom behaviour in association with 142 dietary elements. Symptom onset and symptom exacerbation were associated with dietary elements by 55% (128) and 70% (164) of all IBD participants, respectively. Fruit and vegetables were most frequently identified, with dairy products, gluten-containing bread, and foods with a high fat content also considered deleterious. Of all IBD participants, 35% (82) associated symptom reduction with dietary elements. The identified foods were typically low in fibre, saturated fatty acids, and easily digestible. No statistically significant differences were seen between the type or number of dietary elements and disease subtype or recent disease activity. The association between diet and symptoms in patients with IBD and the mechanism(s) involved warrant further research and may lead to the development of IBD specific dietary guidelines.

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Section: Discussionmentioning

confidence: 99%

Inflammatory Bowel Disease: Are Symptoms and Diet Linked?

et al. 2020

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“…However, a 2009 Cochrane review found “uncertain” effects of elimination and vegan diets as a result of inadequate data reporting (92); little if any research has since been published on the effects of elimination diets on RA. The lack of recent research on this topic is concerning, since emerging research has shown that diets eliminating specific foods can be effective for other inflammatory and autoimmune conditions, such as Crohn's disease (93, 94) and eosinophilic esophagitis (95–98). Eliminating gluten has also been found to not only ameliorate intestinal signs and symptoms in celiac disease (CD) but also to improve arthritis/arthralgia in some CD patients (99, 100).…”

Section: Associations Between Diet and Ramentioning

confidence: 99%

Nutrition Interventions in Rheumatoid Arthritis: The Potential Use of Plant-Based Diets. A Review

et al. 2019

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Rheumatoid arthritis (RA), a chronic inflammatory autoimmune disease, affects roughly 1% of the world's population. RA pathogenesis remains unclear, but genetic factors account for 50–60% of the risk while the remainder might be linked to modifiable factors, such as infectious diseases, tobacco smoking, gut bacteria, and nutrition. Dietary triggers may play an inciting role in the autoimmune process, and a compromised intestinal barrier may allow food components or microorganisms to enter the blood stream, triggering inflammation. In addition, excessive body weight may affect pharmacotherapy response and the likelihood of disease remission, as well as the risk of disease mortality. Evidence suggests that changes in diet might play an important role in RA management and remission. Several studies have shown improvements in RA symptoms with diets excluding animal products. Studies have also shown that dietary fiber found in these plant-based foods can improve gut bacteria composition and increase bacterial diversity in RA patients, thus reducing their inflammation and joint pain. Although some of the trigger foods in RA patients are individualized, a vegan diet helps improve symptoms by eliminating many of these foods. This review examines the potential role of a plant-based diet in mediating RA symptoms. Further research is needed to test the effectiveness of plant-based diets on joint pain, inflammation, and quality of life in patients with RA.

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“…One-third of IBD patients underwent IBS-like symptoms, and partial exclusion of some fermentable components may be associated with benefits to functional symptoms. For example, in a small study with 16 CD patients in remission, a strict exclusion diet of wheat and dairy products for 2 weeks significantly decreased function symptoms such as abdominal pain [68]. In a prospective study with 89 IBD patients in remission, a low-FODMAP diet for 6 weeks reduced IBS-like symptoms while it increased quality of life in patients [69].…”

Section: Exclusion Dietsmentioning

confidence: 99%

Inflammatory Bowel Diseases and Food Additives: To Add Fuel on the Flames!

et al. 2019

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Inflammatory bowel diseases (IBDs) develop in genetically predisposed individuals in response to environmental factors. IBDs are concomitant conditions of industrialized societies, and diet is a potential culprit. Consumption of ultra-processed food has increased over the last decade in industrialized countries, and epidemiological studies have found associations between ultra-processed food consumption and chronic diseases. Further studies are now required to identify the potential culprit in ultra-processed food, such as a poor nutritional composition or the presence of food additives. In our review, we will focus on food additives, i.e., substances from packaging in contact with food, and compounds formed during production, processing, and storage. A literature search using PubMed from inception to January 2019 was performed to identify relevant studies on diet and/or food additive and their role in IBDs. Manuscripts published in English from basic science, epidemiological studies, or clinical trials were selected and reviewed. We found numerous experimental studies highlighting the key role of food additives in IBD exacerbation but epidemiological studies on food additives on IBD risk are still limited. As diet is a modifiable environmental risk factor, this may offer a scientific rationale for providing dietary advice for IBD patients.

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Persistent symptoms in patients with Crohn’s disease in remission: An exploratory study on the role of diet

Abstract: Our exploratory study suggests that dietary interventions such as an elimination diet may reduce GI symptoms in patients with CD in remission.

Cited by 16 publications

References 22 publications

Inflammatory Bowel Disease: Are Symptoms and Diet Linked?

Inflammatory Bowel Disease: Are Symptoms and Diet Linked?

Nutrition Interventions in Rheumatoid Arthritis: The Potential Use of Plant-Based Diets. A Review

Inflammatory Bowel Diseases and Food Additives: To Add Fuel on the Flames!

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