Persistent Unilateral Renal Hypertension in the Rabbit

Flasher, Jack; Drury, Douglas R.; Sobin, Sidney S.

doi:10.1152/ajplegacy.1949.158.3.433

Cited by 15 publications

(5 citation statements)

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“…The blood-pressure levels found in these resting rabbits (Table 1) were considerably lower than those reported by others (Landis et al 1938;Kapp, Friedland & Landis, 1941;Flasher et al 1949) in the unanaesthetized rabbit, but the systolic pressure approaches the figure found by Pickering (1945) with Grant's capsule, in the range 63-87 mm Hg for normal rabbits and 96-125 mm Hg for hypertensives. respectively.…”

Section: Resultscontrasting

confidence: 49%

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The behaviour of the blood pressure in normal and hypertensive rabbits in response to l‐noradrenaline and to ganglion block by hexa‐ or pentamethonium

Conway¹

1955

The Journal of Physiology

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Section: Resultscontrasting

confidence: 49%

“…Fourteen rabbits, mostly lop-eared, have been studied before and after hypertension was induced by renal encapsulation with moulded latex (Flasher, Drury & Sobin, 1949). Capsules were applied to both kidneys, or to one kidney with simultaneous removal of the other.…”

Section: Methodsmentioning

confidence: 99%

The behaviour of the blood pressure in normal and hypertensive rabbits in response to l‐noradrenaline and to ganglion block by hexa‐ or pentamethonium

Conway¹

1955

The Journal of Physiology

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“…The right kidney was removed and the left was enclosed in a molded latex capsule. 9 Arterial pressure began to rise within 24 hours and often reached a maximum value at three to five days, or~continued~to rise slowly for several weeks.…”

Section: Renal Hypertensionmentioning

confidence: 99%

Loss of Baroreflex Bradycardia in Renal Hypertensive Rabbits

Alexander

DeCuir

1966

Circulation Research

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The degree of reflex bradycardia elicited by a sudden, brief rise in arterial pressure was used as an index of sino-aortic reflex activity in conscious rabbits with early renal hypertension. Change in heart rate was measured every 6 seconds after injected angiotensin which caused a rise in blood pressure of 15 to 60 mm Hg. Ninety-one tests for reflex bradycardia were made in 30 normal rabbits; 14. p i them were tested intermittently during the 1 to 40 day period following unilateral riephrectomy and latex encapsulation of the opposite kidney. A total of 62 tests were made after arterial pressure had. risen 10 to 80 mm Hg, average 35,-above control values. Average decrease in heart rate was significantly less and frequency of negligible reflex bradycardia was much higher in hypertensives than controls. Individual" rabbits showed no tendency for reflex bradycardia to return toward normal magnitude. However, the vasomotor component of the sino-aortic reflex mechanism in renal hypertensive rabbits buffered the pressor response to angiotensin in a normal manner Rej.v setting of sino-aortic reflex activity under hypertensive conditions is dis-_ cussed. ADDITIONAL KEY WORDSheart rate reflex resetting of sino-aortic "reflexes baroreceptors and heart rate angiotensin and hypertension carotid sinus and aortic nerves conscious rabbits• Information concerning function of sinoaortic reflexes in man or in conscious laboratory animals with arterial hypertension is scanty, although it is important in the broader question of baroreflex resetting in hypertension. The term "reset" as applied to the sinoaortic baroreflex system has not been defined precisely in the literature, but is used here to mean that the effector response has returned to normal magnitude or rate under conditions that initially altered it. In this definition sino-aortic receptor activity, afferent or efferent nerve discharge can be substituted for effector response, the effector organs being, of course, the heart and blood vessels.

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“…Direct measurements of BP were made in rabbits [10). After shaving and alcohol rubbing the ear to well dilate the central auricularartery,an arterial puncture was performed with a 22-gauge needle.…”

Section: Pb Measurementsmentioning

confidence: 99%

Blood Pressure in Unilaterally Nephrectomized Rabbits: A Correlation with Serum Renotropic Activity

Areas

Enriquez²,

Newsome³

et al. 1991

Nephron

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Over 40 years ago, Grollman reported that unilateral nephrectomy (UN) in rabbits precipitated hypertension and suggested that liberation of a pressor substance by an ischemic or damaged kidney could not be causative. Because others were unable to corroborate that UN in rabbits led to increased blood pressure (BP), we followed 7 rabbits after UN and 4 rabbits after a sham operation. At 7–10 days postoperatively, BP increased from the baseline average of 83 to an average of 97 mm Hg in the UN rabbits (p < 0.01). In contrast, BP did not change significantly after sham operation. Measurements of blood chemistries, serum insulin levels and digoxin-like substances showed no significant changes after UN which would explain the BP rise, but plasma renin activity (PRA) rose from 11.4 to 30.3 ng/ml/h, (p < 0.05). However, similar elevations occurred in sham-operated rabbits that showed no significant change in BP, i.e. 10.6–26.2 ng/ml/h. Measurement of serum renotropic activity after UN, but not after sham operation, also showed a significant elevation above baseline 97.6% (p < 0.001). The renotropic activity 7–10 days after UN unlike PRA correlated significantly with the changes in BP(r = 0.87, p < 0.001). We conclude that BP rises after UN in rabbits, confirming Grollman’s findings. The correlative rise in BP and serum renotropic activity may play an important role in the BP elevation after UN.

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Persistent Unilateral Renal Hypertension in the Rabbit

Cited by 15 publications

References 0 publications

The behaviour of the blood pressure in normal and hypertensive rabbits in response to l‐noradrenaline and to ganglion block by hexa‐ or pentamethonium

The behaviour of the blood pressure in normal and hypertensive rabbits in response to l‐noradrenaline and to ganglion block by hexa‐ or pentamethonium

Loss of Baroreflex Bradycardia in Renal Hypertensive Rabbits

Blood Pressure in Unilaterally Nephrectomized Rabbits: A Correlation with Serum Renotropic Activity

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