Persistently Increased Serum Concentration of Heart-Type Fatty Acid-Binding Protein Predicts Adverse Clinical Outcomes in Patients With Chronic Heart Failure

Niizeki, Takeshi; Takeishi, Yasuchika; Arimoto, Takanori; Nakatani, Naoki; Hirono, Osamu; Watanabe, Tetsu; Nitobe, Joji; Miyashita, Takehiko; Miyamoto, Takuya; Koyama, Yo; Kitahara, Tatsuro; Suzuki, Satoshi; Sasaki, Toshiki; Kubota, Isao

doi:10.1253/circj.72.109

Cited by 62 publications

(48 citation statements)

References 20 publications

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“…H-FABP has been used as a diagnostic marker for chronic congestive heart failure in adult patients. In this study, serum levels of H-FABP were used to monitor and guide therapy of congestive heart failure [24] .…”

Section: Discussionmentioning

confidence: 99%

Urinary NT-proBNP, NGAL, and H-FABP May Predict Hemodynamic Relevance of Patent Ductus Arteriosus in Very Low Birth Weight Infants

Tosse¹,

Pillekamp²,

Verde

et al. 2012

Neonatology

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Background: Hemodynamically significant patent ductus arteriosus (hsPDA) is the most common functional cardiovascular disease in preterm infants. The necessity to treat hsPDA can neither be derived solely from clinical nor from echocardiographic criteria. Objective: The aim of this study was to establish non-invasive parameters which can differentiate hsPDA from non-hsPDA. Methods: Urinary protein levels of NT-proBNP, NGAL, and H-FABP were measured and correlated with the necessity of therapy for PDA. In 37 neonates (<1,500 g), urinary protein concentrations were tested on days 0, 2, and 7 by ELISA methodology. Of 37 infants, 12 required therapeutic interventions according to current treatment standards. Results: Infants receiving an intervention for PDA showed significantly higher levels of pro-BNP, NGAL, and H-FABP at all time points except for NT-proBNP on day 0. Infants requiring a second or third course of ibuprofen had significantly higher levels of H-FABP and NGAL. In all samples, the concentration of the three proteins correlated positively with each other. Conclusions: The present study shows that measurement of urinary proteins is a powerful and non-invasive method to quantify the effect of PDA on systemic perfusion in preterm infants. Furthermore, NGAL and H-FABP may be used to indicate the necessity of pharmacological or surgical treatment of PDA.

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Section: Discussionmentioning

confidence: 99%

Urinary NT-proBNP, NGAL, and H-FABP May Predict Hemodynamic Relevance of Patent Ductus Arteriosus in Very Low Birth Weight Infants

Tosse¹,

Pillekamp²,

Verde

et al. 2012

Neonatology

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show abstract

“…Heart-type faty acid-binding protein (H-FABP) is used as a prognosis tool biomarker in human cardiac disease as it indicates myocardial stretch and injury in chronic heart failure even in children. Higher levels of H-FABP are associated with a poorer long-term outcome in both adults and children [61][62][63][64][65]. Although litle work has been carried out in other species, this is an area of research which has potential, in addition to investigating whether H-FABP levels are raised prior to infarction and/or heart disease.…”

Section: The Role Of Faty Acids In Cardiovascular Function and Diseasementioning

confidence: 99%

Fatty Acids in Veterinary Medicine and Research

Simpson¹,

Mostyn²

2017

Fatty Acids

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Faty acid regulation is an essential process for all animals. A number of studies have shown that diet afects the levels/availability of faty acids in the body but increasingly an evidence shows that disease states can alter the amounts within the body too. Faty acid levels and availability have been altered by a number of diseases, disorders and reactions including inlammatory responses, heart disease and heart failure and wound repair. They are also essential during the growth and development stages of animals. The amount of research into the consequences of diferent faty acid intake and levels in various disease states and during development has increased in both humans and animals. This review presents an overview of the research undertaken to date and highlights the importance, uses and beneits of understanding the roles of faty acids in both the healthy animals and animals under difering disorders and diseases.

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“…В нескольких недавних исследованиях были получе ны результаты оценки Н FABP с целью диагностики и стратификации риска при остром коронарном синдроме [28][29][30]. Помимо его использования при остром коронарном синдроме, значение этого био маркера дополнительно продемонстрировано при ДХСН и ТЭЛА [31][32][33].…”

Section: оригинальные исследованияunclassified

Diagnostic and prognostic impact of heart injury biomarkers (troponin I and heart-type fatty acid binding protein) in patient with acute exacerbations of chronic obstructive pulmonary disease

Баймаканова¹,

Авдеев²

2012

Pulʹmonologiâ (Mosk.)

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Persistently Increased Serum Concentration of Heart-Type Fatty Acid-Binding Protein Predicts Adverse Clinical Outcomes in Patients With Chronic Heart Failure

Cited by 62 publications

References 20 publications

Urinary NT-proBNP, NGAL, and H-FABP May Predict Hemodynamic Relevance of Patent Ductus Arteriosus in Very Low Birth Weight Infants

Urinary NT-proBNP, NGAL, and H-FABP May Predict Hemodynamic Relevance of Patent Ductus Arteriosus in Very Low Birth Weight Infants

Fatty Acids in Veterinary Medicine and Research

Diagnostic and prognostic impact of heart injury biomarkers (troponin I and heart-type fatty acid binding protein) in patient with acute exacerbations of chronic obstructive pulmonary disease

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