Persisting thrombin activity in elderly patients with atrial fibrillation on oral anticoagulation is decreased by anti-inflammatory therapy with intensive cholesterol-lowering treatment

Kuilenburg, Janet van; Lappegård, Knut Tore; Sexton, Joe; Plesiewicz, Izabela; Lap, Paul; Bouwels, Leon; Sprong, Tom; Mollnes, Tom Eirik; Verheugt, Freek W.A.; Pop, Gheorghe

doi:10.1016/j.jacl.2011.05.003

Cited by 23 publications

(25 citation statements)

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“…Van Kuilenburg and colleagues (2011) [13] observed that the increase in serum total cholesterol was positively correlated with an increase in circulating bFGF. Therefore, a diet high in cholesterol may increase the synthesis of bFGF and consequently induce proliferation solely in the stroma of the gland, as seen in our study.…”

Section: Discussionmentioning

confidence: 99%

“…Increased consumption of SFA increases the synthesis of total cholesterol and LDL-cholesterol and lowers HDL-cholesterol, increasing the risk for the development of BPH [2]. Van Kuilenburg and colleagues (2011) showed that dyslipidemia is associated with increased circulation of several growth factors, including basic fibroblast growth factor (bFGF) [13]. This growth factor acts as an important stimulator of fibroblast proliferation and collagen synthesis and deposition in the extracellular matrix and stimulates angiogenesis [14].…”

Section: Introductionmentioning

confidence: 99%

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Diets Rich in Saturated and Polyunsaturated Fatty Acids Induce Morphological Alterations in the Rat Ventral Prostate

et al. 2014

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AimTo evaluate the influence of dietary lipid quality on the body mass, carbohydrate metabolism and morphology of the rat ventral prostate.Materials and MethodsWistar rats were divided into four groups: SC (standard chow), HF-S (high-fat diet rich in saturated fatty acids), HF-P (high-fat diet rich in polyunsaturated fatty acids) and HF-SP (high-fat diet rich in saturated and polyunsaturated fatty acids). We analyzed body mass, fat mass deposits, plasma blood, insulin resistance and the ventral prostate structure.ResultsGroups that received high-fat diets were heavier and presented larger fat deposits than SC group. The HF-S and HF-SP groups had higher glucose, insulin and total cholesterol serum levels and insulin resistance compared with the SC. The acinar area, epithelium height and area density of the lumen were higher in the HF-SP than in the other groups. The epithelium area density and epithelial cell proliferation were greater in the HF-P and HF-SP than in the SC group. All of the groups that received high-fat diets had greater area density of the stroma, area density of smooth muscle cells and stromal cell proliferation compared with the SC group.ConclusionDiets rich in saturated and/or polyunsaturated fatty acids induced overweight. Independently of insulin resistance, polyunsaturated fatty acids increased prostate stromal and epithelial cell proliferation. Saturated fatty acids influenced only stromal cellular proliferation. These structural and morphometric alterations may be considered risk factors for the development of adverse remodeling process in the rat ventral prostate.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Diets Rich in Saturated and Polyunsaturated Fatty Acids Induce Morphological Alterations in the Rat Ventral Prostate

et al. 2014

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“…Statins favourably modulate blood coagulation by exerting mild anticoagulant and antiplatelet effects [26,27]. The results of statins on blood clotting can also be observed in patients with AF [28]. In the context of VKA, drug-drug interactions may be however of key importance.…”

Section: Discussionmentioning

confidence: 99%

Prediction of unstable anticoagulation with acenocoumarol versus warfarin in atrial fibrillation

2017

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(1-3). Proportions of patients with ≥ 2 points and 0-1 points in the SAMe-TT 2 R 2 score who had the time in therapeutic range (TTR) ≤ 70% were similar (61 [67%] vs. 63 [56%], p = 0.11). A modified score, involving medical history (myocardial infarction [MI] and chronic obstructive pulmonary disease [COPD], 1 point), statin treatment (1 point) and tobacco use (2 points) had a higher area under the curve (AUC) in patients on acenocoumarol compared to p = 0.042 (Cardiol J 2017; 24, 5: 477-483)

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“…La FA confiere un estado protrombótico o de hipercoagulabilidad, con alteraciones de la hemostasia, trombosis, activación de plaquetas y disfunción endotelial 22 . Se ha asociado a niveles elevados de marcadores procoagulantes, tales como GT y complejos TAT [23][24] , los que persisten elevados incluso en pacientes que están en tratamiento anticoagulante oral 25 . Los niveles plasmáticos elevados de fragmentos 1+2 de protrombina y los complejos TAT, reflejan la GT in vivo y sus niveles han sido asociados a mayor riesgo de accidente cerebrovascular [26][27] .…”

Section: Discussionunclassified

Evaluación de la anticoagulación con rivaroxaban, en pacientes con fibrilación auricular no valvular de reciente diagnóstico

et al. 2016

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Persisting thrombin activity in elderly patients with atrial fibrillation on oral anticoagulation is decreased by anti-inflammatory therapy with intensive cholesterol-lowering treatment

Cited by 23 publications

References 35 publications

Diets Rich in Saturated and Polyunsaturated Fatty Acids Induce Morphological Alterations in the Rat Ventral Prostate

Diets Rich in Saturated and Polyunsaturated Fatty Acids Induce Morphological Alterations in the Rat Ventral Prostate

Prediction of unstable anticoagulation with acenocoumarol versus warfarin in atrial fibrillation

Evaluación de la anticoagulación con rivaroxaban, en pacientes con fibrilación auricular no valvular de reciente diagnóstico

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