Abstract-Growing the entrepreneurial spirit is currently very difficult due to the lack of good support from the government on a large scale as well as families on a small scale. Actually entrepreneurship is very easy. It only requires strong determination and the ability to read opportunities. The ability to read opportunities here is able to see opportunities from different aspects of difference. A plural Indonesian society is a huge market for an entrepreneur. Entrepreneur who has a creative and innovative personality, with the characteristics of full confidence, has the initiative, has the motive of achievement, has leadership spirit, and dare to take risks with full calculation In this paper trying to describe the development of entrepreneurial spirit through multicultural approach in Indonesia.