Personal Permanent Hair Dye Use Is Not Associated with Bladder Cancer Risk: Evidence from a Case-Control Study

Abstract

Whether personal hair dye use is associated with an increased bladder cancer risk has been controversial and there are limited available data addressing this issue. We used a large case-control study of 712 incident bladder cancer cases and 712 age-, gender-, and ethnicity-matched controls to evaluate this association. After adjusting for confounding variables, the use of permanent hair dye was not associated with bladder cancer risk in all subjects [odds ratio (OR)

Internal exposure of hairdressers to permanent hair dyes: a biomonitoring study using urinary aromatic diamines as biomarkers of exposure

“…This suspicion is supported by some epidemiological studies (e.g. GagoDominguez et al 2001) while other investigators could not confirm these findings (Lin et al 2006;Rollison et al 2006;Bolt and Golka 2007).…”

Personal use of hair dyes and risk of bladder cancer: a meta-analysis of epidemiologic data

“…The current meta-analysis consists of 10 studies included in two previous meta-analyses [10,11] and two recent case-control studies that were published subsequently [12,13]. The meta-analysis by Huncharek and Kupelnick included seven studies published from 1980 to 2001, whereas the analysis by Takkouche et al included 10 studies published during the period 1977-2004. Excluding the two recent case-control studies that appeared after publication of the earlier meta-analyses, our independent literature search did not identify any new studies not previously evaluated by Takkouche et al [11] or Huncharek and Kupelnick [10].…”

“…Summary of recent case-control studies included in the present meta-analysis Lin et al [12] conducted a large case-control study of hair dye use and bladder cancer. A total of 712 incident bladder cancer cases and 712 age-, gender-, and ethnicity-matched controls were included in this study.…”

“…Huncharek and Kupelnick suggested that an association exists; while, Takkouche et al concluded that there was no association between personal hair dye use and risk of bladder cancer. Since the publication of these meta-analyses, two new case-control studies have been reported [12,13].…”

Hair dye use and risk of human cancer

“…A total of 11 case-control studies (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15) and three cohort studies (16)(17)(18) have investigated the relationship between personal hair dye use and risk of bladder cancer (Table 1). These investigations assessing hair dye use and risk of bladder cancer have produced inconsistent results.…”