The current literature on health care workers wearing personal protective equipment (PPE) indicates that they experience a wide variety of discomfort, especially for nurses in the emergency department. This article contributes mainly that the discomfort caused by wearing PPE could be classified into 7 categories: (1) dizziness, (2) dyspnea, (3) nausea, (4) micturition desire, (5) retroauricular pain, (6) thirst, and (7) inconvenience at work. More complaints about uncomfortable symptoms and pressure sores were reported by female physicians and nurses and by those working at designated hospitals or in intensive care units and working in PPE for more than 4 hours. Key implications for emergency nursing practice are that shorter time per shift, adequate protective products, and proper psychological interventions may be beneficial to relieve discomfort.