Personal Reflections on Clinical Investigations

Bean, William B.

doi:10.1146/annurev.nu.02.070182.000245

Cited by 8 publications

(4 citation statements)

References 19 publications

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“…Forty-eight hours later the answer was in: it worked! Their important report (14) and subsequent reports of the effectiveness of nicotinic acid in human pellagra [see Bean (4)] appeared that same fall.…”

Section: Nicotinic Acid Pyridoxine Biotin and Avidinmentioning

confidence: 92%

Untitled

1989

Annu. Rev. Nutr.

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I This chapter cites only a few original articles from the relevant literature. It emphasizes work on the lactic acid bacteria during the period between about 1936 and 1952 and is an extension of previous accounts of this subject (75,79). Reviews that cover nutritional requirements of both these and other microorganisms in greater detail are available (16,18,55,77,34). Reviews dealing extensively with development and use of microbiologic assays are also available (1,3,77) . A useful anthology of papers in bacterial nutrition has appeared (35).

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Section: Nicotinic Acid Pyridoxine Biotin and Avidinmentioning

confidence: 92%

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1989

Annu. Rev. Nutr.

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“…Pellagra developed in a few people in the first group, but none in the second group. Some of them developed the disease after one year of living in rural areas [27]. In 1810, the Italian, Giovanni Battista Marzari, put forward the hypothesis that corn lacked a certain vital ingredient, which was denied by most medical authorities.…”

Section: History Of Research On Pellagramentioning

confidence: 99%

“…Pelagra rozwinęła się u kilku osób z pierwszej grupy, lecz u żadnego z badanych w drugiej grupie. U części z nich choroba wystąpiła po roku ponownego zamieszkiwania na obszarach wiejskich [27]. W 1810 roku Włoch Giovanni Battista Marzari wysunął hipotezę, że w kukurydzy brakuje pewnego składnika koniecznego do życia, która była negowana przez większość autorytetów medycznych.…”

Section: Historia Badań Nad Pelagrąunclassified

The history of pellagra

Jaworek¹,

Łazarczyk²,

Hałubiec³

et al. 2021

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Currently pellagra is usually the subject of dermatological or non-dermatological case reports. Since the first description of the disease, its cause has remained unknown for many years. There were no known methods of prevention and treatment. For two centuries, pellagra was an incurable disease and caused several hundred thousand deaths in Europe and North America. Research by clinicians and scientists has made it possible to refute the common theory of the infectious etiology of the disease and link the disease epidemic to maize, which was then the primary source of food for the poor. Consumption limited to this grain resulted in an extreme deficiency of niacin (vitamin B 3 ) and symptoms of pellagra. Niacin supplementation caused the lesions to regress, and became crucial to combat the epidemic. The article presents the first descriptions, the greatest outbreaks of the epidemic and the stormy process of discovering data on the etiology of pellagra, as well as typical clinical features of the diseases.

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“…That the latter method failed to gain wide recognition I believe stems from several factors: (a) other reasonably satisfactory tradi tional methods (e.g. the thiochrome method for thiamine) were available, (b) S. aureus is a potential pathogen, and (c) the method was not validated by careful recovery experiments or cross-checking against other available (14) and subsequent reports of the effectiveness of nicotinic acid in human pellagra [see Bean (4)] appeared that same fall.…”

Section: Microbiologic Assaysmentioning

confidence: 99%

Nutrition Research with Lactic Acid Bacteria: A Retrospective View

Snell¹

1989

Annu. Rev. Nutr.

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From the above discussion, it is apparent that one or another of the lactic acid bacteria requires each of the B vitamins required by animals and that assay methods developed during study of nutrition of bacteria and yeasts have played a large role in the initial or independent discovery, isolation, and characterization of vitamins, vitamin derivatives, and functionally similar substances. Clear examples include biotin, biocytin, lipoic acid, nicotinic acid, pantothenic acid, pantetheine, folic acid and tetrahydrofolic acid (and their derivatives), pyridoxal, pyridoxamine, and pyridoxamine phosphate. Improved assay methods that use these organisms also have provided much of the currently available information concerning distribution and stability of the vitamins in natural products, while quantitative inconsistencies between assays, when traced to their origin, have frequently revealed previously unknown metabolic precursors, products, or functions of the vitamins and have provided explanations of the mechanisms by which certain peptide growth factors act. Extension of such studies to organisms that cannot yet be grown in media of known composition should provide additional insights into currently obscure areas of nutrition.

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Personal Reflections on Clinical Investigations

Cited by 8 publications

References 19 publications

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The history of pellagra

Nutrition Research with Lactic Acid Bacteria: A Retrospective View

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