Personal sleep debt and daytime sleepiness mediate the relationship between sleep and mental health outcomes in young adults

Dickinson, David L.; Wolkow, Alexander; Rajaratnam, Shanthakumar M W; Drummond, Sean P.A.

doi:10.1002/da.22769

Cited by 59 publications

(46 citation statements)

References 53 publications

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“…The interaction between sleep duration and mental health in adolescents is significant, with insufficient sleep and daytime sleepiness having the greatest relationship with mood disorder. 31,32 The relationships among sleep duration, training volume, and mental health were examined in athletes 6 to 18 years old. Female athletes, athletes who self-reported a history of clinically diagnosed depression or anxiety, and athletes who reported a prior sport-related injury were less likely to meet sleep recommendations.…”

Section: Sleep and Mental Healthmentioning

confidence: 99%

The Psychosocial Implications of Sport Specialization in Pediatric Athletes

Brenner

LaBotz

Sugimoto

et al. 2019

Journal of Athletic Training

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Data on the psychosocial implications of sport specialization in pediatric athletes are lacking. Sport specialization often requires increased training hours and may predispose young athletes to social isolation, poor academic performance, increased anxiety, greater stress, inadequate sleep, decreased family time, and burnout. Sport specialization frequently introduces multiple stressors that could be expected to adversely affect mental health and function in young athletes and may increase the risk for burnout. This may be confounded by altered sleep duration and quality, increased drive for elite status, and perfectionistic personality types. The signs and symptoms of burnout in young athletes can be difficult to detect. It is important to be aware of the possible diagnosis of burnout in young athletes who display vague symptoms and a decrease in academic performance. The purpose of this review was to survey the available literature on sport specialization in young athletes and its association with mental health, sleep, the drive for success in sport, and burnout.

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Section: Sleep and Mental Healthmentioning

confidence: 99%

The Psychosocial Implications of Sport Specialization in Pediatric Athletes

Brenner

LaBotz

Sugimoto

et al. 2019

Journal of Athletic Training

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“…Disturbances to the sleep/wake system that impair daily functioning leading to reduced health are prevalent, with around two thirds of the UK's adult population (67%) reporting some sort of sleep issue [1,2]. It is well documented that restricted sleep and disrupted circadian rhythmicity result in changes to many physiological processes such as endocrine regulation [3] and core body temperature (CBT) [4], as well as being linked with a variety of health issues, including mood disturbances [5], increased morbidity and mortality rates [6], and declines in cognitive and physical performance [7]. Disruption to circadian and sleep/wake processing represents a substantial economic burden on society, primarily through loss of productivity, absenteeism and poor performance [8], and increases the risk of occupational accidents [9].…”

Section: Introductionmentioning

confidence: 99%

Resetting the late timing of ‘night owls’ has a positive impact on mental health and performance

et al. 2019

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Background: There is conflict between living according to our endogenous biological rhythms and our external environment, with disruptions resulting in negative consequences to health and performance. This is often documented in shift work and jet lag, but 'societal norms' (eg, typical working hours) can create profound issues for 'night owls', people whose internal biological timing predisposes them to follow an unusually late sleep-wake cycle. Night owls have also been associated with health issues, mood disturbances, poorer performance and increased mortality rates. Methods: This study used a randomized control trial design aimed to shift the late timing of night owls to an earlier time (phase advance), using non-pharmacological, practical interventions in a real-world setting. These interventions targeted light exposure (through earlier wake up/sleep times), fixed meals times, caffeine intake and exercise. Results: Overall, participants demonstrated a significant advance of~2 h in sleep/wake timings as measured by actigraphy and circadian phase markers (dim light melatonin onset and peak time of the cortisol awakening response), whilst having no adverse effect on sleep duration. Notably, the phase advance was accompanied by significant improvements to self-reported depression and stress, as well as improved cognitive (reaction time) and physical (grip strength) performance measures during the typical 'suboptimal' morning hours. Conclusions: Our findings propose a novel strategy for shifting clock timing towards a pattern that is more aligned to societal demands that could significantly improve elements of performance, mental health and sleep timing in the real world.

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“…Exclusion criteria for all subjects included mental retardation, chronic somatic illness, current use of medication, substance abuse/ dependence, age over 17. 5 Table 1). All subjects consumed less than three cups of coffee daily (or the equivalent amount of other caffeinated products).…”

Section: Subjectsmentioning

confidence: 99%

“…Symptomatology in insomnia and depression are tightly linked and share many common features as well as common mechanisms [2,3]. Disordered sleep also increases the risk of depression [4,5]. The majority of patients with depressive disorder have symptoms of disturbed sleep (insomnia or hypersomnia), which also belong to the diagnostic criteria of the disorder [6].…”

Section: Introductionmentioning

confidence: 99%

Epigenetic dysregulation of genes related to synaptic long-term depression among adolescents with depressive disorder and sleep symptoms

et al. 2019

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Objectives: This study aimed to test the hypothesis that sleep and depression have independent effects on brain development and plasticity in adolescents, and that these changes are reflected in changes in the epigenome. Methods: Participants were 17 medication-free adolescent boys (age 16.05 ± 0.80 years, mean ± standard deviation (SD); eight cases with depression and sleep symptoms, nine healthy controls). Sleep was assessed by polysomnography recordings and the Pediatric Daytime Sleepiness Scale (PDSS) and Athens Insomnia Scale (AIS). Participants underwent a clinical evaluation. DNA methylation of blood leukocytes was measured by Illumina 450K array, and Ingenuity Pathway analysis was applied to identify the most significant pathways with differentially methylated positions (DMPs). Secondary analysis of the identified loci included linear correlations between methylation and the subjectively rated scales of sleep, depression and sleep microarchitecture. Results: Due to small sample size, we found no genome-wide significant differences in methylation between cases and controls. However, pathway analysis identified the synaptic long-term depression (LTD) canonical pathway (p ¼ 0.00045) when the best 500 DMPs from the original caseecontrol design were included. A flattened dissipation of slow wave sleep, tiredness and depression severity values correlated with five of 10 sites from the LTD pathway (IGF1R, PLAG16, PLA2R1, PPP2C5 and ERK12) in the secondary analysis when the caseecontrol status was controlled for. Conclusion: Among adolescents, depressive disorder with sleep symptoms is associated with a distinctive epigenetic pattern of DNA methylation in blood leukocytes. The enrichment of DMPs on genes related to synaptic LTD emphasizes the role of sleep in synaptic plasticity and the widespread physiological consequences of disturbed sleep.

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Personal sleep debt and daytime sleepiness mediate the relationship between sleep and mental health outcomes in young adults

Cited by 59 publications

References 53 publications

The Psychosocial Implications of Sport Specialization in Pediatric Athletes

The Psychosocial Implications of Sport Specialization in Pediatric Athletes

Resetting the late timing of ‘night owls’ has a positive impact on mental health and performance

Epigenetic dysregulation of genes related to synaptic long-term depression among adolescents with depressive disorder and sleep symptoms

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