Personal Use of Hair Dyes and Risk of Cancer

Takkouche, Bahi; Etminan, Mahyar; Montes-Martínez, Agustín

doi:10.1001/jama.293.20.2516

Cited by 137 publications

(105 citation statements)

References 55 publications

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“…Hair dye use has been associated with an increased risk of various cancers in some studies, but these results have generally not been confirmed (14). The present study is the first to assess hair relaxers in relation to a cancer.…”

Section: Discussionmentioning

confidence: 57%

Hair Relaxers Not Associated with Breast Cancer Risk: Evidence from the Black Women's Health Study

Rosenberg

Boggs

Adams‐Campbell

et al. 2007

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Hair relaxers (straighteners) have been used by millions of African American women, often for many years. Relaxer ingredients can enter the body through scalp lesions and burns. Because manufacturers are not required to list all ingredients, these products may contain unknown harmful substances. We assessed hair relaxer use in relation to breast cancer incidence in the Black Women's Health Study, a nationwide follow-up study of African American women. Information on hair relaxer use was collected in 1997; 48,167 women were followed subsequently through 2003 for incident breast cancer. Incidence rate ratios of breast cancer were estimated with Cox regression. During 266,298 person-years of followup, 574 incident cases of breast cancer were ascertained. There were no increases in breast cancer risk associated with any categories of duration of hair relaxer use, frequency of use, age at first use, number of burns experienced during use, or type of relaxer used. The incidence rate ratio for use at least seven times a year for 20 or more years relative to use for less than a year was 0.98 (95% confidence interval, 0.78-1.39). These results suggest that hair relaxer use does not increase the incidence of breast cancer in African American women.

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Section: Discussionmentioning

confidence: 57%

Hair Relaxers Not Associated with Breast Cancer Risk: Evidence from the Black Women's Health Study

Rosenberg

Boggs

Adams‐Campbell

et al. 2007

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…35,148,[438][439][440][441][442][443][444][445][446][447] In a recent meta-analysis of 14 studies, Takkouche et al 450 reported a significant excess risk of NHL among ever-users of hair dyes, compared to never-users (meta-RR 5 1.23, 95% CI: 1.07-1.42). There was heterogeneity of results by study design, as the relative risk estimates observed in the casecontrol studies were significantly elevated (meta-RR 5 1.27, 95% CI: 1.06-1.53), but those in the 2 cohort studies were not (meta-RR 5 1.10, 95% CI: 0.94-1.28).…”

Section: Hair Dyesmentioning

confidence: 99%

The non-Hodgkin lymphomas: A review of the epidemiologic literature

et al. 2007

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“…In a population-based case-control study of men and women, permanent hair dye use, particularly use of dark hair coloring products, was associated with increased risk for multiple myeloma, based on a small number of exposed cases (n 5 12 permanent users among men and women; n 5 6 permanent brown/brunette users among women). 225 A recent meta-analysis 228 reported an inverse association among cohort studies (meta-RR 5 0.69, 95% CI: 0.28-1.66), while a weak positive association was observed for case-control studies (meta-RR 5 1.31, 95% CI: 1.03-1.67). The inconsistency within and among study findings may be a reflection of differences in exposure recall and in exposure misclassification, as hair color chemical formulations and patterns of hair dye use-including color and product type-have varied over time.…”

Section: Cosmetologists Hairdressers and Hair Coloring Product Exposmentioning

confidence: 99%

Multiple myeloma: A review of the epidemiologic literature

et al. 2007

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Multiple myeloma, a neoplasm of plasma cells, accounts for 15% of lymphatohematopoietic cancers (LHC) and 2% of all cancers in the US. Incidence rates increase with age, particularly after age 40, and are higher in men, particularly African American men. The etiology is unknown with no established lifestyle, occupational or environmental risk factors. Although several factors have been implicated as potentially etiologic, findings are inconsistent. We reviewed epidemiologic studies that evaluated lifestyle, dietary, occupational and environmental factors; immune function, family history and genetic factors; and the hypothesized precursor, monoclonal gammopathies of undetermined significance (MGUS). Because multiple myeloma is an uncommon disease, etiologic assessments can be difficult because of small numbers of cases in occupational cohort studies, and few subjects reporting exposure to specific agents in case-control studies. Elevated risks have been reported consistently among persons with a positive family history of LHC. A few studies have reported a relationship between obesity and multiple myeloma, and this may be a promising area of research. Factors underlying higher incidence rates of multiple myeloma in African Americans are not understood. The progression from MGUS to multiple myeloma has been reported in several studies; however, there are no established risk factors for MGUS. To improve our understanding of the causes of multiple myeloma, future research efforts should seek the causes of MGUS. More research is also needed on the genetic factors of multiple myeloma, given the strong familial clustering of the disease. ' 2007 Wiley-Liss, Inc.Key words: multiple myeloma; epidemiology Multiple myeloma is a malignancy of plasma cells that results in an overproduction of light and heavy chain monoclonal immunoglobulins. The specific immunoglobulin secreted by the malignant cell is the M-protein, named in reference to its monoclonal characteristics. It is found in the serum and/or urine of persons affected with multiple myeloma.

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Personal Use of Hair Dyes and Risk of Cancer

Cited by 137 publications

References 55 publications

Hair Relaxers Not Associated with Breast Cancer Risk: Evidence from the Black Women's Health Study

Hair Relaxers Not Associated with Breast Cancer Risk: Evidence from the Black Women's Health Study

The non-Hodgkin lymphomas: A review of the epidemiologic literature

Multiple myeloma: A review of the epidemiologic literature

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