Personality and bipolar disorder: dissecting state and trait associations between mood and personality

Barnett, Jennifer H.; Huang, Jue; Perlis, Roy H.; Young, M M; Rosenbaum, Jerrold F.; Nierenberg, Andrew A.; Sachs, Gary S.; Nimgaonkar, V.L.; Miklowitz, David J.; Smoller, Jordan W.

doi:10.1017/s0033291710002333

Cited by 100 publications

(119 citation statements)

References 67 publications

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“…These results are in line with a considerable number of previous studies that have described patients with BD to have higher levels of Neuroticism [26][27][28][29][30] , lower levels of Extraversion 27,30,31 , and lower Conscientiousness 26,32 .…”

Section: Discussionsupporting

confidence: 91%

Influence of personality traits in coping skills in individuals with bipolar disorder

Souza

Grassi‐Oliveira²,

Brietzke³

et al. 2014

Rev. psiquiatr. clín.

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Background: Bipolar disorder is marked by alterations in coping skills which in turn impacts the disease course. Personality traits are associated with coping skills and for this reason it has been suggested that personality traits of patients with BD may have influence over their coping skills. Objective: To investigate possible associations between coping skills and personality in individuals with bipolar disorder (BD). Methods: Thirty-five euthymic subjects with BD were compared with 40 healthy controls. Coping skills were evaluated using Ways of Coping Checklist Revised and Brief-COPE. Personality traits were assessed by Neo Personality Inventory. MANCOVA was used for between groups comparison. Results: Regarding coping, individuals with BD reported more frequent use of emotion-focused strategies than problem-focused strategies, and high levels of neuroticism and low levels of extroversion and conscientiousness on personality measures. Neuroticism influenced negatively the use of problem-focused strategies, and positively emotion-focused coping. Conscientiousness influenced the use of problem-focused strategies in both groups. There was a significant difference between emotion focused coping and personality traits between BD and control groups. Discussion: Personality traits seem to modulate coping skills and strategies in BD which may be took into account for further interventions.

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Section: Discussionsupporting

confidence: 91%

Influence of personality traits in coping skills in individuals with bipolar disorder

Souza

Grassi‐Oliveira²,

Brietzke³

et al. 2014

Rev. psiquiatr. clín.

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“…Further, because of the relative small sample size for genetic analysis, further studies on larger samples are needed to confirm our findings. Second, the inclusion of patients with different mood status could alter the association among the genetic variants and the TCI dimensions because of the known effects of mood state on TCI (e.g., [11]). However, to control for this possible confounding factor, we considered in the analysis the HAMD and BRMRS scores, as well as the mood status as identified by SCID I.…”

Section: Discussionmentioning

confidence: 99%

“…Indeed, associations between personality traits and BD may occur for several reasons. In particular, (1) early and repeated mood episodes may modulate personality (e.g., [8]), (2) early trauma events may both modulate personality traits (e.g., [9]) and increase the risk to develop BD (e.g., [10]), (3) mood status modulates personality traits [11], (4) a partial shared genetic background has been suggested [12], and (5) personality traits can be modulated by residual symptoms as well [11]. …”

Section: Introductionmentioning

confidence: 99%

Temperament and Character Inventory in Bipolar Disorder versus Healthy Controls and Modulatory Effects of 3 Key Functional Gene Variants

et al. 2017

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Background: Bipolar disorder (BD) has been associated with temperamental and personality traits, although the relationship is still to be fully elucidated. Several studies investigated the genetic basis of temperament and character, identifying catechol-O-methyltransferase (COMT), brain derived neurotrophic factor (BDNF), and serotonin transporter (5-HTT) gene variants as strong candidates. Methods: In the GECO-BIP study, 125 BD patients and 173 HC were recruited. Subjects underwent to a detailed assessment and the temperament and character inventory 125 items (TCI) was administrated. Three functional genetic variants within key candidate genes (COMT rs4680, BDNF rs6265, and the serotonin-transporter-linked polymorphic region (5-HTTLPR)) were genotyped. Univariate and multivariate analyses were performed. Results: Compared to HC, BD patients showed higher scores in novelty seeking (NS; p = 0.001), harm avoidance (HA; p < 0.001), and self transcendence (St; p < 0.001), and lower scores in self directness (p < 0.001) and cooperativeness (p < 0.001) TCI dimensions. Concerning the genetic analyses, COMT rs4680 was associated with NS in the total sample (p = 0.007) and in the male subsample (p = 0.022). When performing the analysis in the HC and BD samples, the association was confirmed only in HC (p = 0.012), and in the HC male subgroup in particular (p = 0.004). BDNF rs6265 was associated with St in the BD group (p = 0.017). Conclusion: COMT rs4680 may modulate NS in males in the general population. This effect was not detected in BD patients, probably because BD alters the neurobiological basis of some TCI dimensions. BDNF rs6265 seems to modulate St TCI dimension only in BD patients, possibly modulating the previously reported association between rs6265 and BD treatment response. Further studies are needed to confirm our findings.

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“…Finally, it has been suggested that the overrepresentation of bipolar disorder observed in population-based studies of creativity may reflect a preference for the unconventional lifestyle provided by creative occupations, as many suffering with bipolar disorder have trouble maintaining stable employment. Indeed, the personality traits that seem to be most associated with choosing a creative occupation are openness and impulsivity [33], which are associated with bipolar disorder as discussed below [34,35,36,37]. However, a multitude of studies of both eminent and “everyday” creativity consistently suggest a relationship between creativity and risk for bipolar spectrum disorders that warrants further research.…”

Section: Bipolar Disorder and Creativity: “Madness Versus Genius”mentioning

confidence: 99%

“…Hyperthymic temperament is further associated with creativity in healthy subjects, as are hypomanic personality traits, which predict risk for bipolar disorder [53,54,55]. Bipolar and creative individuals also have higher neuroticism, extraversion, and openness personality scores compared with noncreative controls [33,36,37,38,51,52,56,57,58,59,60,61]. Openness to experience is a central feature of creativity, with an estimated effect size of 0.71 [33,62,63,64,65,66].…”

Section: Positive Traits In the Space Between Madness And Geniusmentioning

confidence: 99%

Positive Traits in the Bipolar Spectrum: The Space between Madness and Genius

Greenwood¹

2016

Complex Psychiatry

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Bipolar disorder is a severe, lifelong mood disorder for which little is currently understood of the genetic mechanisms underlying risk. By examining related dimensional phenotypes, we may further our understanding of the disorder. Creativity has a historical connection with the bipolar spectrum and is particularly enhanced among unaffected first-degree relatives and those with bipolar spectrum traits. This suggests that some aspects of the bipolar spectrum may confer advantages, while more severe expressions of symptoms negatively influence creative accomplishment. Creativity is a complex, multidimensional construct with both cognitive and affective components, many of which appear to reflect a shared genetic vulnerability with bipolar disorder. It is suggested that a subset of bipolar risk variants confer advantages as positive traits according to an inverted-U-shaped curve with clinically unaffected allele carriers benefitting from the positive traits and serving to maintain the risk alleles in the population. The association of risk genes with creativity in healthy individuals (e.g., NRG1), as well as an overall sharing of common genetic variation between bipolar patients and creative individuals, provides support for this model. Current findings are summarized from a multidisciplinary perspective to demonstrate the feasibility of research in this area to reveal the mechanisms underlying illness.

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Personality and bipolar disorder: dissecting state and trait associations between mood and personality

Abstract: While there are clear state effects of mood on self-reported personality, personality variables during euthymia predict future course of illness. Personality disturbances in extraversion, neuroticism and openness may be enduring characteristics of patients with BD.

Cited by 100 publications

References 67 publications

Influence of personality traits in coping skills in individuals with bipolar disorder

Influence of personality traits in coping skills in individuals with bipolar disorder

Temperament and Character Inventory in Bipolar Disorder versus Healthy Controls and Modulatory Effects of 3 Key Functional Gene Variants

Positive Traits in the Bipolar Spectrum: The Space between Madness and Genius

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