Personality and risk of adult asthma in a prospective cohort study

Loerbroks, Adrian; Li, Jian; Bosch, Jos A.; Herr, Raphael M.; Angerer, Peter

doi:10.1016/j.jpsychores.2015.04.002

Cited by 13 publications

(8 citation statements)

References 51 publications

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“…With regards to neuroticism, other studies have found up to a fifteen-year longitudinal association between neuroticism and the development of asthma [5,13,15]; our study extends this period up to 29 years. Even after this extremely long follow-up time, the association between neuroticism and asthma was still rather strong, with effects similar to concurrently measured major depression (lowest vs highest quartile).…”

Section: Discussionsupporting

confidence: 66%

“…Similarly, several studies have shown that the personality trait neuroticism influences the risk for asthma in adults, possibly increasing the risk up to three times among those with high neuroticism scores [13][14][15]. Neuroticism is characterized by a tendency to experience emotional instability and excessive worry, and has notable stability across the lifespan [16,17].…”

Section: Introductionmentioning

confidence: 99%

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Asthma and affective traits in adults: a genetically informative study

Lehto

Pedersen

Almqvist³

et al. 2019

Preprint

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Depression, anxiety and high neuroticism (affective traits) are often comorbid with asthma. A causal direction between the affective traits and asthma is difficult to determine, however, it may be that there is a common underlying pathway attributable to shared genetic factors. Our aim was to determine whether a common genetic susceptibility exists for asthma and each of the affective traits.An adult twin cohort from the Swedish Twin Register underwent questionnaire-based health assessments (n=23 693) and genotyping (n=15 908). Firstly, questionnaire-based associations between asthma and affective traits were explored. This was followed by genetic analyses: a) polygenic risk scores (PRS) for affective traits were used as predictors of asthma, and b) linkage-disequilibrium score regression based on genome-wide association results from UK Biobank was used to quantify genetic correlations.Analyses found that the questionnaire-based associations between asthma and each affective trait were associated (OR 1.7, 95%CI 1.5-1.9 major depression, OR 1.5, 95%CI 1.3-1.6 anxiety, and OR 1.6, 95% 1.4-1.8 high neuroticism). Genetic susceptibility for neuroticism explained the variance in asthma with a dose response effect; that is, those in the highest neuroticism PRS quartile were more likely to have asthma than those in the lowest quartile (OR 1.4, 95%CI 1.2-1.6). Genetic correlations were found between depression and asthma (rg= 0.17), but not for anxiety or neuroticism score.We conclude that the observed comorbidity between asthma and the affective traits may in part be due to shared genetic influences between asthma and depression and neuroticism, but not anxiety.

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Section: Discussionsupporting

confidence: 66%

Section: Introductionmentioning

confidence: 99%

Asthma and affective traits in adults: a genetically informative study

Lehto

Pedersen

Almqvist³

et al. 2019

Preprint

View full text Add to dashboard Cite

show abstract

“…Presuming with some approximation that high psychoticism according to the Eysenck model means a high level of openness to experience and low agreeableness and conscientiousness [6], that study fails to confirm our observation concerning the association of asthma with psychoticism. On the other hand, a study by Loerbroks et al assessed the association of asthma with the personality traits and not with the degree of asthma control [29]. Perhaps the additional high value of the psychoticism dimension determines poor control of the course of the disease in neurotic subjects with asthma, as the psychological profile of a person with poor control of asthma which emerges from our research is a neurotic person with considerable intensity of psychoticism traits, including a propensity to lie.…”

Section: Discussionmentioning

confidence: 70%

“…This is probably due to the fact that patients with poor asthma control are likely to show high values of neuroticism and psychoticism, as well as components of the latter. Indeed, a longitudinal prospective study on a population of 12 thousand confirmed the association of neuroticism with the development and course of bronchial asthma [29]. Such studies, however, were not conducted for the psychological construct of psychoticism according to the Eysenck model because it used a questionnaire designed based on the Big Five model of personality.…”

Section: Discussionmentioning

confidence: 99%

Bronchial asthma control degree and the temperament structure according to the Eysenck model

Mokros

Kuna

Pietras

2020

pdia

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Introduction Asthma is a disease of a psychosomatic nature. The control of asthma is still poor in approximately 5% of patients, despite introduction of modern inhalant drugs and psychotherapeutic interventions. Aim To evaluate whether the degree of bronchial asthma control is related to the characteristics of temperament according to Eysenck’s concept. Material and methods The study was conducted on a group of 111 bronchial asthma patients and 44 healthy subjects. In all of them, the Eysenck temperament questionnaire was administered and the level of asthma control was determined. Results Increase in the scale of neuroticism was associated with an 1.83-fold increase in the likelihood of poor asthma control. Increase in the result on the psychoticism scale and lie scale of about one point was associated with a slightly smaller increased risk of poor asthma control (respectively: 1.49-fold and 1.61-fold). Conclusions The structure of temperament of a person with poor control of bronchial asthma can be characterized. Patients with poor asthma control have a higher level of neuroticism, psychoticism and propensity to lie, compared with the healthy population and subjects with good or partial bronchial asthma control.

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“…The literature to date is inconsistent regarding the association between personality traits and asthma, although high Neuroticism has been reported (Huovinen, Kaprio, & Koskenvuo, 2001;Loerbroks, Li, Bosch, Herr, & Angerer, 2015;McCann, 2011). Nevertheless, high Openness to Experience, but low Extraversion, Agreeableness and Conscientiousness have also been described in persons with asthma (≥ 25 years old) (McCann, 2011).…”

Section: Personality Traits In Asthma and Adhdmentioning

confidence: 99%

Treatment adherence in Asthma and Attention Deficit Hyperactivity Disorder (ADHD), Personality traits, Beliefs about medication and Illness perception

Emilsson¹

2017

Linköping University Medical Dissertations

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Adherence to medication in asthma and attention deficit hyperactivity disorder (ADHD) is important because medication may prevent serious consequences, possibly with lifelong effects. Several factors have been identified that influence adherence to medication in these disorders, but the importance of personality traits, beliefs about medication and illness perception has been insufficiently explored. The overall aim of this thesis was to study adherence to medication in asthma and ADHD, and in particular factors associated with adherence.The participants (n=268) in Study I were recruited epidemiologically and consisted of young adults with asthma, aged 22 years (±1 year). Impulsivity and, in men Antagonism and Alexithymia were associated with low adherence among respondents with regular asthma medication (n=109). The participants (n=35) in Study II were recruited from primary care clinics and consisted of adults (mean age 53 years). In men, Neuroticism was associated with low adherence, but Conscientiousness with high adherence. Beliefs about the necessity of medication were positively associated with adherence behaviour in women. In the total sample, a positive necessity-concern differential of beliefs predicted higher adherence. The participants in Study III, IV (n=101) and V (n=99) were recruited from Child and Adolescent Psychiatric clinics and consisted of adolescents with ADHD on long-term ADHD medication. Study IV assessed the reliability and validity of Swedish translations of the Beliefs about Medicines Questionnaire-specific (BMQ-Specific) and Brief Illness Perception Questionnaire (B-IPQ) for use in adolescents with ADHD. Exploratory Principal Component Analysis (PCA) loadings of the BMQ-Specific items confirmed the original components, the specific-necessity and specific-concerns. The exploratory PCA for B-IPQ revealed two components; the first one, B-IPQ Consequences, captured questions regarding perceptions of the implication of having ADHD (items 1, 2, 5, 6 and 8) and the second one, B-IPQ-Control, the perceptions of the ability to manage the ADHD disorder (items 3, 4 and 7). Adherence correlated positively with BMQnecessity-concern differential but negatively with beliefs about medication regarding concerns and side effects as well as Antagonism. Adolescents with more beliefs in the necessity, but with less concerns and side effects were less intentionally non-adherent. Adolescents with more perceptions that ADHD affected life showed less unintentional non-adherence. Negative Affectivity was associated with beliefs in the necessity of medication, but also with concern about medication and side effects. Negative Affectivity was positively associated with perceived consequences in life caused by ADHD and less control over ADHD. Hedonic Capacity was associated with less concerns about medication. In conclusion: In asthma and ADHD, adherence was associated with personality and beliefs about medications treatment. The personality traits showed numerous associations with perception about ADHD a...

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Personality and risk of adult asthma in a prospective cohort study

Cited by 13 publications

References 51 publications

Asthma and affective traits in adults: a genetically informative study

Asthma and affective traits in adults: a genetically informative study

Bronchial asthma control degree and the temperament structure according to the Eysenck model

Treatment adherence in Asthma and Attention Deficit Hyperactivity Disorder (ADHD), Personality traits, Beliefs about medication and Illness perception

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