Personality and serotonin transporter genotype interact with social context to affect immunity and viral set-point in simian immunodeficiency virus disease

Capitanio, John P.; Abel, Kristina; Mendoza, Sally P.; Blozis, Shelley A.; McChesney, Michael B.; Cole, Steve W.; Mason, William A.

doi:10.1016/j.bbi.2007.05.006

Cited by 73 publications

(53 citation statements)

References 53 publications

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“…Importantly, by the end of treatment, social status differences in serum LH were no longer evident, suggesting the system was maximally suppressed at that time by this dose of E2. Nevertheless, these observations add support to pervious reports that individuals with this genotype are more vulnerable to the adverse consequences of social subordination [28] or other types of psychosocial stress [20,25,[57][58][59]. This finding should be expanded to a larger population analysis to confirm whether SLC6A4 polymorphisms potentiate stress-induced reproductive compromise via enhanced E2-negative feedback inhibition.…”

Section: Serum Lhsupporting

confidence: 65%

Social Subordination and Polymorphisms in the Gene Encoding the Serotonin Transporter Enhance Estradiol Inhibition of Luteinizing Hormone Secretion in Female Rhesus Monkeys1

Michopoulos¹,

Berga²,

Kaplan³

et al. 2009

Biology of Reproduction

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Psychosocial factors, particularly social stress, may compromise reproduction. However, some individuals may be more susceptible to socially induced infertility. The present study used group-housed, adult, ovariectomized rhesus monkeys to test the hypothesis that exposure to psychosocial stress, imposed by social subordination, would enhance estradiol (E2)-negative feedback inhibition of LH. Because polymorphisms in the gene encoding the serotonin transporter (SLC6A4) may contribute to individual differences in response to adverse environments, we determined whether subordinate females with the short-promoter-length allele (s-variant) would show greater suppression of LH. Subordinate females, particularly those with the s-variant SLC6A4 genotype, received significantly higher rates of noncontact aggression from more dominant cage mates and had consistently lower body weights. Serum LH was not influenced by social status in the absence of E2. In contrast, subordinate females were hypersensitive to E2-negative feedback inhibition of LH. Furthermore, serum LH in subordinate females with s-variant SLC6A4 genotype was maximally suppressed by Day 4 of treatment, whereas nadir concentrations were not reached until later in treatment in other females. Finally, pharmacological elevation of serum cortisol potentiated E2-negative feedback inhibition in all females. The current data suggest that infertility induced by psychosocial stressors may be mediated by hypersensitivity to E2-negative feedback and that polymorphisms in the SLC6A4 gene may contribute to differences in reproductive compromise in response to chronic stress.

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Section: Serum Lhsupporting

confidence: 65%

Social Subordination and Polymorphisms in the Gene Encoding the Serotonin Transporter Enhance Estradiol Inhibition of Luteinizing Hormone Secretion in Female Rhesus Monkeys1

Michopoulos¹,

Berga²,

Kaplan³

et al. 2009

Biology of Reproduction

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“…Humans and rhesus monkeys, particularly adult individuals, likewise both display stable and pronounced individual differences in social functioning. Moreover, Low-Social (LS) monkeys initiate fewer approaches and groom-presents and spend less time in conspecific proximity than do High-Social (HS) monkeys [4,5], suggesting that LS and HS monkeys differ in their motivation to interact with others. LS monkeys also receive fewer approaches, lipsmacks, and groom-presents compared to HS monkeys, indicating that LS animals may be perceived as less socially attractive [4].…”

Section: Introductionmentioning

confidence: 99%

Early Predictors of Impaired Social Functioning in Male Rhesus Macaques (Macaca mulatta)

et al. 2016

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Autism spectrum disorder (ASD) is characterized by social cognition impairments but its basic disease mechanisms remain poorly understood. Progress has been impeded by the absence of animal models that manifest behavioral phenotypes relevant to ASD. Rhesus monkeys are an ideal model organism to address this barrier to progress. Like humans, rhesus monkeys are highly social, possess complex social cognition abilities, and exhibit pronounced individual differences in social functioning. Moreover, we have previously shown that Low-Social (LS) vs. High-Social (HS) adult male monkeys exhibit lower social motivation and poorer social skills. It is not known, however, when these social deficits first emerge. The goals of this study were to test whether juvenile LS and HS monkeys differed as infants in their ability to process social information, and whether infant social abilities predicted later social classification (i.e., LS vs. HS), in order to facilitate earlier identification of monkeys at risk for poor social outcomes. Social classification was determined for N = 25 LS and N = 25 HS male monkeys that were 1–4 years of age. As part of a colony-wide assessment, these monkeys had previously undergone, as infants, tests of face recognition memory and the ability to respond appropriately to conspecific social signals. Monkeys later identified as LS vs. HS showed impairments in recognizing familiar vs. novel faces and in the species-typical adaptive ability to gaze avert to scenes of conspecific aggression. Additionally, multivariate logistic regression using infant social ability measures perfectly predicted later social classification of all N = 50 monkeys. These findings suggest that an early capacity to process important social information may account for differences in rhesus monkeys’ motivation and competence to establish and maintain social relationships later in life. Further development of this model will facilitate identification of novel biological targets for intervention to improve social outcomes in at-risk young monkeys.

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“…Fifth, and related to the previous point, there has been growing recognition that “one size does not fit all;” that is, the relationship between precipitating factors on the one hand (e.g., adverse early experiences, encounter with a pathogen) and physical or psychological disease outcomes on the other hand is often moderated by host factors, such as sex, genotype, and personality. In human medicine, this has been referred to as “personalized medicine,” and parallel studies in nonhuman primates of moderated relationships involving, for example, personality and genotype, [e.g., Capitanio et al, 2008] fit easily within, and contribute to, this development in medicine. Sixth, there has been a greater awareness that the management of captive populations of nonhuman primates must focus not only on preventing disease, but must also attend to the social needs of these highly social animals.…”

Section: Resultsmentioning

confidence: 99%

Social Processes and Disease in Nonhuman Primates: Introduction to the Special Section

Capitanio

2012

American J Primatol

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Most nonhuman primate species are remarkably social, but their social nature presents many challenges, including increased opportunities for pathogen transmission and development of disease (both physical and psychological). An interdisciplinary symposium was convened at the 2010 annual meeting of the American Society of Primatologists on the topic of social processes and disease in nonhuman primates, and four articles from that session, as well as a fifth that was separately solicited, appear in this special section. The articles reflect a variety of disciplines and perspectives that highlight the many ways that social processes can impact disease processes (and vice versa) in this highly social taxon. This is an increasingly active area of research interest as a consequence of technological developments and the availability of long-term field data. The continuing loss of primate habitat in the wild, climate change, and the need to manage high densities of primates in captivity, however, all add urgency to our need to better understand the bidirectional relationship between social factors and disease processes.

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Personality and serotonin transporter genotype interact with social context to affect immunity and viral set-point in simian immunodeficiency virus disease

Cited by 73 publications

References 53 publications

Social Subordination and Polymorphisms in the Gene Encoding the Serotonin Transporter Enhance Estradiol Inhibition of Luteinizing Hormone Secretion in Female Rhesus Monkeys1

Social Subordination and Polymorphisms in the Gene Encoding the Serotonin Transporter Enhance Estradiol Inhibition of Luteinizing Hormone Secretion in Female Rhesus Monkeys1

Early Predictors of Impaired Social Functioning in Male Rhesus Macaques (Macaca mulatta)

Social Processes and Disease in Nonhuman Primates: Introduction to the Special Section

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