Personality, Anxiety, and Individual Variation in Psychophysiological Habituation and Sensitization to Painful Stimuli

Nakamura, Yoshio; Donaldson, Gary; Okifuji, Akiko

doi:10.4172/2167-0846.1000156

Cited by 3 publications

(2 citation statements)

References 32 publications

(37 reference statements)

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“…For statistical analysis, two continuous composite scores were created for baseline pretrauma anxiety (trait anxiety = z(EPM index) + z(ASR Amplitude)) and post-trauma anxiety (PTSD-like behavior = z(EPM index) + z(ASR Amplitude) + z(ASR Habituation)). Note that the ASR Habituation index was not included in the trait anxiety score, as human studies on the relation between trait anxiety and habituation are debated (Campbell et al, 2014;Donaldson, 2014;Grillon et al, 1993;Martin-Soelch et al, 2006).…”

Section: Behavioral Profiling Of Ptsd-like Behaviormentioning

confidence: 99%

Pre-trauma memory contextualization as predictor for PTSD-like behavior in male rats

Sep

Sarabdjitsingh

Geuze

et al. 2021

Preprint

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While many people experience potentially threatening events during their life, only a minority develops posttraumatic stress disorder (PTSD). The identification of individuals at risk among those exposed to trauma is crucial for PTSD prevention in the future. Since re-experiencing trauma elements outside of the original trauma-context is a core feature of PTSD, we investigate if the ability to bind memories to their original encoding context (i.e. memory contextualisation) predicts PTSD vulnerability. We hypothesize that pre-trauma neutral memory contextualization (under stress) negatively relates to PTSD-like behavior, in a prospective design using the cut-off behavioral criteria rat model for PTSD. 72 male Sprague Dawley rats were divided in two experimental groups to assess the predictive value of 1) memory contextualization without acute stress (NS-group) and 2) memory contextualization during the recovery phase of the acute stress-response (S-group) for susceptibility to PTSD-like behavior. A powerful extension to regression analysis -path analysis- was used to test this specific hypothesis, together with secondary research questions. Following traumatic predator scent stress, 19.4% of the rats displayed PTSD-like behavior. Results showed a negative relation between pre-trauma memory contextualization and PTSD-like behavior, but only in the NS-group. Pre-trauma memory contextualization was positively related to fear association in the trauma environment, again only in the NS group. If the predictive value of pre-trauma contextualization of neutral information under non-stressful conditions for PTSD susceptibility is replicated in prospective studies in humans, this factor would supplement already known vulnerability factors for PTSD and improve the identification of individuals at risk among the trauma exposed, especially those at high trauma risk such as soldiers deployed on a mission.

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Section: Behavioral Profiling Of Ptsd-like Behaviormentioning

confidence: 99%

Pre-trauma memory contextualization as predictor for PTSD-like behavior in male rats

Sep

Sarabdjitsingh

Geuze

et al. 2021

Preprint

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“…Few studies have focused on individual differences in habituation of responses to pain (e.g. [1,5,17,33,44,47,62,63]). Individual differences may play a more important role in habituation to pain than in the initial response to a painful stimulus.…”

Section: Individual Differencesmentioning

confidence: 99%

Habituation to pain: a motivational-ethological perspective

Paepe

Williams

Crombez

2019

Pain

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Facets of neuroticism and musculoskeletal symptoms. A study of middle-aged twins

Vassend¹,

Orvik²,

Czajkowski³

et al. 2016

Nor J Epidemiol

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Clinical and epidemiological studies have shown that both site-specific and more widespread musculoskeletal (MS) conditions are linked to anxiety and depression symptoms. However, the nature of this relationship is poorly understood, particularly in terms of underlying genetic and environmental influences. Furthermore, the personality trait neuroticism has been shown to be related to common emotional symptoms and somatic distress as well as to more serious psychiatric and medical disorders. In modern personality theory, the broad neuroticism domain is conceptualized as consisting of a set of lower-order facets, such as anxiety, hostility, and depression, which may be differentially related to various health outcome measures. So far, the role of neuroticism facets as risk factors for MS conditions has not been explored in genetically informative designs. In the current study, the relationship between MS symptoms and six neuroticism facets was investigated in bivariate analyses and in regression models including sex, education level, and general health indices as control variables. Using multivariate twin modeling, genetic and environmental influences on the phenotypes and the associations among them were determined. The sample consisted of 746 monozygotic (MZ) and 770 dizygotic (DZ) twins in the age group of 50-65 (mean = 57.11 years, SD = 4.5). The results showed that a single factor accounted for about 50% of the overall variance in MS symptom reporting. Two neuroticism facets, N1: anxiety and N3: depression, appeared as significant in the regression analyses. Both these facets and MS symptoms were strongly influenced by genetic factors [heritability (h 2 ) = 0.46-0.54]. While there was a considerable overlap in genetic risk factors between the three phenotypes, a large proportion (71%) of the genetic variance in MS symptoms was unique to the phenotype, and not shared with the neuroticism facets.This is an open access article distributed under the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Personality, Anxiety, and Individual Variation in Psychophysiological Habituation and Sensitization to Painful Stimuli

Cited by 3 publications

References 32 publications

Pre-trauma memory contextualization as predictor for PTSD-like behavior in male rats

Pre-trauma memory contextualization as predictor for PTSD-like behavior in male rats

Habituation to pain: a motivational-ethological perspective

Facets of neuroticism and musculoskeletal symptoms. A study of middle-aged twins

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