Personality changes in Alzheimer's disease

Talassi, E; Cipriani, Gabriele; Bianchetti, Angelo; Trabucchi, Marco

doi:10.1080/13607860601086603

Cited by 28 publications

(23 citation statements)

References 23 publications

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“…Overall, there seems to be a predictable increase in neuroticism and a decrease in extraversion, conscientiousness and possibly openness to experience in MCI patients compared to control subjects. This change is in contrast with the overall stability of personality traits observed in control subjects [37], in whom modifications occur, if at all, slowly and imperceptibly [47], but never as quickly and profoundly as observed in our clinical group. In keeping with the findings of our study, Siegler et al [48] found that patients diagnosed with memory impairment had higher values in neuroticism and lower ones in openness, extraversion and conscientiousness.…”

Section: Discussioncontrasting

confidence: 53%

The Evolution of Personality in Patients with Mild Cognitive Impairment

Donati

Studer

Petrillo

et al. 2013

Dement Geriatr Cogn Disord

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Aims: To describe personality traits and their changes in mild cognitive impairment (MCI) and control subjects. Methods: Sixty-three MCI and 90 control subjects were asked to describe their current personality traits by the Structured Interview for the Five-Factor Model (SIFFM). For each subject, a close relative retrospectively assessed these descriptions both as to the previous and current personality traits, using the Revised NEO Personality Inventory, Form R (NEO-PI-R). Results: Self-assessed MCI subjects reported significantly lower scores in the openness dimension than control subjects [F(1, 150) = 9.84, p = 0.002, η_p² = 0.06]. In current observer ratings, MCI subjects had higher scores on neuroticism [F(1, 137) = 7.55, p = 0.007, η_p² = 0.05] and lower ones on extraversion [F(1, 137) = 6.40, p = 0.013, η_p² = 0.04], openness [F(1, 137) = 9.93, p = 0.002, η_p² = 0.07], agreeableness [F(1, 137) = 10.18, p = 0.002, η_p² = 0.07] and conscientiousness [F(1, 137) = 25.96, p < 0.001, η_p² = 0.16]. Previous personality traits discriminated the groups as previous openness [odds ratio (OR) = 0.97, 95% confidence interval (CI) = 0.95-0.99, p = 0.014] and conscientiousness (OR = 0.96, 95% CI 0.94-0.98, p = 0.001) were negatively related to MCI group membership. In MCI subjects, conscientiousness [F(1, 137) = 19.20, p < 0.001, η_p² = 0.12] and extraversion [F(1, 137) = 22.27, p < 0.001, η_p² = 0.14] decreased between previous and current evaluations and neuroticism increased [F(1, 137) = 22.23, p < 0.001, η_p² = 0.14], whereas no significant change was found in control subjects. Conclusions: MCI subjects undergo significant personality changes. Thus, personality assessment may aid the early detection of dementia.

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Section: Discussioncontrasting

confidence: 53%

The Evolution of Personality in Patients with Mild Cognitive Impairment

Donati

Studer

Petrillo

et al. 2013

Dement Geriatr Cogn Disord

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“…The Previous research has demonstrated that patients in different stages of AD display an increase in neuroticism and a decrease in extraversion, openness, conscientiousness, and agreeableness in relation to normal elderly [8][9][10] . A recent study has reported patients being quieter, relying on others, disliking of company, unhappy and regressive after onset of AD, when compared to healthy control subjects [11] . Patients with AD furthermore express more apathy, increased rigidity and less interest in hobbies.…”

mentioning

confidence: 99%

Personality Features in Subjective Cognitive Impairment and Mild Cognitive Impairment – Early Indicators of Dementia

Ausén

Edman

Almkvist

et al. 2009

Dement Geriatr Cogn Disord

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Objectives: The purpose of the present study was to investigate patterns of personality in patients with subjective cognitive impairment (SCI) and mild cognitive impairment (MCI), compared to healthy controls. Methods: We assessed24 patients with SCI, 35 patients with MCI and 26 healthy controls with the self-report questionnaire Swedish Universities Scales of Personality measuring aspects of neuroticism/anxiety proneness, extraversion, and aggression-hostility. Results: Patients with SCI and MCI showed significantly more Somatic Trait Anxiety, Psychic Trait Anxiety and Stress Susceptibility than healthy controls. Moreover, there was a significant increase in Detachment in patients with MCI and a significant decrease in Adventure Seeking in patients with SCI, relative to healthy controls. Conclusions: Patients with SCI and MCI presented specific patterns of personality alterations with higher scores in traits related to anxiety proneness and aggression-hostility and lower in traits of extraversion. In most subscales differences followed a sequential pattern with gradually increasing scores from healthy controls, to patients with SCI and further to MCI. The groups differed in amount and type of symptoms, suggesting that patterns of personality may be related to degree of cognitive impairment.

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“…ISSN: 0214-9877. pp:177-186 183 con su alrededor, indiferencia con sus actividades y tareas, y con menor probabilidades de percibir estímulos de bajos niveles de intensidad. (Boyle, Wilson, Schneider, Bienias & Bennett, 2008;Duberstein et al, 2011;Evans & Rothbart, 2007;Hertzog, Kramer, Wilson & Lindenberger, 2009;Talassi, Cipriani, Bianchetti & Trabucchi, 2007;Tucker-Drob, Johnson & Jones, 2009). La responsabilidad, por su turno, cuando se presenta con niveles bajos y expresión negativa, caracteriza al mayor por su desorganización, desinterés por su trabajo y incapacidad de planificar acciones.…”

Section: Discussionunclassified

Los Cambios De Personalidad en La Enfermedad De Alzheimer

Rodrigues¹,

Castro²,

Española³

2016

Revista INFAD de Psicología

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Previous scientific studies considered the existence of significant differences in the conditions of personality and cognition, in patients with Alzheimer's disease. The aim of this work was to verify the existence of these differences between patients with Alzheimer's disease and patients with normal aging. The sample consisted on 231 participants and was divided into two groups, experimental group (EG) with 103 participants with Alzheimer's disease and a control group (CG), with 128 participants of normal aging. Both groups were subdividing in two subgroups with and without frequency in a day care, rather, with and without cognitive stimulation. The participants were underwent a quantitative assessment based on the application of the MME test and the personality inventory NEO-FFI. Results showed statistically significant differences in all trait of personality, well as in cognition, but it was not possible to establish a pattern of behavior in Alzheimer's patients.Keywords: Alzheimer, normal aging, personality, cognition. RESUMENInvestigaciones científicas anteriores consideran que existen diferencias significativas en las condiciones de cognición y personalidad en enfermos de Alzheimer. El objetivo de este trabajo es verificar la existencia de tales diferencias entre mayores con Alzheimer y mayores en fase de envejecimiento normal. Participaron en esta investigación 231 mayores, divididos por 2 grupos, el grupo experimental (GE) con 103 mayores con diagnóstico clínico de Alzheimer y el grupo de control (GC), con 128 mayores en fase de envejecimiento normal. Ambos grupos fueron subdivididos por 2 subgrupos, con y sin frecuencia en centro de día, es decir, con y sin estimulación cognitiva. Los parti- cipantes fueron evaluados a través de la aplicación del test MME y del inventario NEO-FFI. Los resultados presentaron diferencias estadísticamente significativas en todos los trazos de personalidad, bien como en la cognición, pero no fue posible establecer un patrón de comportamiento en los enfermos de Alzheimer. Palabras-clave: Alzheimer, envejecimiento normal, personalidad, cognición. INTRODUCCIÓNLa enfermedad de Alzheimer es la principal causa de deterioro cognitivo en la vejez y se encuentra asociada a trastornos conductuales y alteraciones cognitivas. Una investigación reciente sobre la enfermedad, concluyó que mayores con Alzheimer, en fase incipiente, tienen diferentes perfiles de personalidad, cuando comparados con mayores en fase de envejecimiento normal. Los resultados se han basado en un aumento estadísticamente significativo del neurotisismo y una disminución de los rasgos de apertura a la experiencia, extraversión y responsabilidad (Callahan, Boustani, Weiner, Beck, Livin, Kellams & Hendrie, 2010; Pocnet, Rossier, Antonietti, Gunten & Phill, 2011).Los cambios de personalidad en el Alzheimer, ocurren normalmente desde el principio de la enfermedad, y su identificación podría contribuir para la caracterización de un patrón pre-mórbido capaz de permitir una intervención más eficaz. Aunque, algunas...

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Personality changes in Alzheimer's disease

Cited by 28 publications

References 23 publications

The Evolution of Personality in Patients with Mild Cognitive Impairment

The Evolution of Personality in Patients with Mild Cognitive Impairment

Personality Features in Subjective Cognitive Impairment and Mild Cognitive Impairment – Early Indicators of Dementia

Los Cambios De Personalidad en La Enfermedad De Alzheimer

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