Personality Correlates of Platelet Monoamine Oxidase (MAO) Activity in Female and Male Subjects

Klinteberg, Britt af; Schalling, Daisy; Edman, Gunnar; Oreland, Lars; Åsberg, Marie

doi:10.1159/000118399

Cited by 67 publications

(28 citation statements)

References 19 publications

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“…Thus, in the male group, criminal offending was associated with psychopathyrelated personality traits. Such traits have been reported to characterize male subjects with early-onset alcohol problems, and are repeatedly found to be linked to underlying biological markers (af Klinteberg et al, 1987;von Knorring et al, 1987;Alm et al, 1996;von Knorring and Oreland, 1996). Among female subjects, the criminal group was found to be higher in cognitive-social anxiety (the psychasthenia scale), and to display less guilty conscience than non-criminal females.…”

Section: Introductionmentioning

confidence: 94%

Child behaviour and adult personality: comparisons between criminality groups in Finland and Sweden

Pulkkinen

Virtanen²,

Klinteberg

et al. 2000

Criminal Behav Ment Health

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Section: Introductionmentioning

confidence: 94%

Child behaviour and adult personality: comparisons between criminality groups in Finland and Sweden

Pulkkinen

Virtanen²,

Klinteberg

et al. 2000

Criminal Behav Ment Health

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“…However, studies relating 5-HT-induced endocrine responses to personality traits are rare. However, an extrapolation from clinical states to personality traits with respect to 5-HT has been demonstrated in the past by other indicators of central 5-HT function like platelet MAO-B [26][27][28] or CSF 5-HIAA levels [29,30].…”

Section: Introductionmentioning

confidence: 99%

Endocrine Responses after <i>d</i>-Fenfluramineand Ipsapirone Challenge: Further Support for Cloninger’s Tridimensional Model of Personality

et al. 2000

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The tridemensional model of personality introduced by Cloninger relates aspects of novelty seeking to the dopaminergic, harm avoidance (HA) to the serotonergic, and reward dependence to the noradrenergic neurotransmitter system. Using a neuroendocrine challenge paradigm, this study investigates whether subjects characterized by blunted cortisol (CORT) responses after ipsapirone (IPS) relate to different subfactors of HA from those characterized by blunted prolactin (PRL) responses after treatment with d-fenfluramine (D-FEN). Moreover, subjects blunted in both responses should differ in scale values of subfactors of HA from those with only one or no blunted reactions. In the first part of the experiment, 16 healthy male volunteers were treated with 15 mg D-FEN. The second part of the study (about 1 year later) consists of a challenge with the partial 5-hydroxytryptamine-1a (5-HT_1a) agonist IPS (10 mg) in the same subjects. The results indicate that blunted PRL responses are accompanied by high values in HA, while the main effect of IPS responsivity did not relate significantly to this dimension. With respect to the subscales of HA, subjects blunted in both responses (PRL–/C–) exhibit significantly higher levels in fatigability and asthenia when compared to all other groups (PRL–/C+, PRL+/C–,PRL+/C+). The data demonstrate that combined challenge tests may shed more light on the biological basis of personality and that HA and most clearly fatigability and asthenia relate to the 5-HT system.

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“…In earlier research, low activity of the enzyme mono amine oxidase (MAO; EC 1.4.3.4) in platelets has consis tently been associated with psychiatric syndromes charac terized as 'disinhibitory psychopathology' [1][2][3] and with temperaments underlying disinhibited or 'externalizing' behaviors [4][5][6], Low activities of platelet MAO tend to be connected with sensation-seeking traits [7,8] and impulsivity [5], Attempts to link the field of biological markers of monoamine systems to that of temperament or personality variables, associated with a disposition to different forms of psychosocial deviancy and psychiatric illness, have been presented [for reviews, see ref. 9.…”

Section: Introductionmentioning

confidence: 99%

Exploring the Connections between Platelet Monoamine Oxidase Activity and Behavior

Klinteberg

Hallman²,

Oreland³

et al. 1992

Neuropsychobiology

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Platelet monoamine oxidase (MAO) activity and serum levels of the adrenal androgen metabolite dehydroepiandrosterone sulfate (DHAS) were measured in 18 male air force pilot recruits and 19 randomly selected male conscripts. Personality scales from three inventories were given, and computerized neuropsychological tests were performed: finger tapping and alternation, reaction time, perceptual maze, perspective fluctuation and lexical decision. The pilot recruits had higher scores in sensation-seeking-related scales suggesting disin-hibited behavior in the social sphere, interest in sports and activities involving some danger, and a need for change. They also had higher scores on an impulsivity scale which comprises sensation-seeking content. In the neuropsychological tasks, the pilot recruits were faster in finger-tapping alternation and performed more efficiently in the perceptual-maze test than the conscripts. In a linear discriminant analysis, neuropsychological-task performance discriminated significantly between the pilot and conscript groups. In the biochemical measures, the pilot recruits had higher DHAS levels but similar MAO activity levels compared to the conscripts, which is in contrast to what has been found in other sensation-seeking groups in comparison to controls. This result is in accordance with the normal scores in one of the impulsivity scales in the pilot recruits, and with the absence of signs of disinhibition in neuropsychological tasks. It is proposed that only some aspects of the impulsivity concept might be critical for the association with low MAO activity.

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Personality Correlates of Platelet Monoamine Oxidase (MAO) Activity in Female and Male Subjects

Cited by 67 publications

References 19 publications

Child behaviour and adult personality: comparisons between criminality groups in Finland and Sweden

Child behaviour and adult personality: comparisons between criminality groups in Finland and Sweden

Endocrine Responses after <i>d</i>-Fenfluramineand Ipsapirone Challenge: Further Support for Cloninger’s Tridimensional Model of Personality

Exploring the Connections between Platelet Monoamine Oxidase Activity and Behavior

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