Personality, dopamine, and Parkinson's disease: Insights from subthalamic stimulation

Lhommée, Eugénie; Boyer, François; Wack, Maxime; Pélissier, Pierre; Klinger, Hélène; Schmitt, Emmanuelle; Bichon, Amélie; Fraix, Valérie; Chabardès, Stéphan; Mertens, Patrick; Castrioto, Anna; Kistner, Andrea; Broussolle, Emmanuel; Thobois, Stéphane; Krack, Paul

doi:10.1002/mds.27065

Cited by 30 publications

(21 citation statements)

References 57 publications

(131 reference statements)

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“…The whole behavioral clinical spectrum illustrates the relation between personality, dopamine and behaviors [ 19 , 51 ]. While PD patients frequently exhibit harm avoidance and introspective traits that refers to baseline personality traits [ 88 ], they also frequently develop apathy, anhedonia, depression, and anxiety during the premotor stage of the disease, the so-called “hypodopaminergic behavioural spectrum” [ 66 , 80 ].…”

Section: Introductionmentioning

confidence: 99%

“…While PD patients frequently exhibit harm avoidance and introspective traits that refers to baseline personality traits [ 88 ], they also frequently develop apathy, anhedonia, depression, and anxiety during the premotor stage of the disease, the so-called “hypodopaminergic behavioural spectrum” [ 66 , 80 ]. Conversely, later in the disease course, patients which are prone to develop ICDs and related disorders, the so-called “hyperdopaminergic behavioural spectrum”, frequently exhibit novelty seeking, and risk-taking personality traits, the exact opposite of the premorbid pattern mentioned above [ 19 , 51 ].…”

Section: Introductionmentioning

confidence: 99%

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Neurobiology and clinical features of impulse control failure in Parkinson’s disease

Béreau

Krack

Brüggemann

et al. 2019

Neurol. Res. Pract.

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Impulse control disorders (ICDs) and other impulsive-compulsive related behaviours are frequent and still under recognized non-motor complications of Parkinson's disease (PD). They result from sensitization of the mesocorticolimbic pathway that arose in predisposed PD patients concomitantly with spreading of PD pathology, non-physiological dopaminergic and pulsatile administration of dopamine replacement therapy (DRT). Neuropsychiatric fluctuations (NPF) reflect the psychotropic effects of dopaminergic drugs and play a crucial role in the emergence of ICDs and behavioral addictions. Dopamine agonists (DA) which selectively target D2 and D3 receptors mostly expressed within the mesocorticolimbic pathway, are the main risk factor to develop ICDs. Neuroimaging studies suggest that dopamine agonists lead to a blunted response of the brain's reward system both during reward delivery and anticipation. Genetic predispositions are crucial for the responsiveness of the mesolimbic system and the development of ICDs with several genes having been identified. Early screening for neuropsychiatric fluctuations, reduction of DA, fractionating levodopa dosage, education of patients and their relatives, are the key strategies for diagnosis and management of ICDs and related disorders.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Neurobiology and clinical features of impulse control failure in Parkinson’s disease

Béreau

Krack

Brüggemann

et al. 2019

Neurol. Res. Pract.

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“…Individuals with higher levels of harm avoidance show anticipatory worry, fear of uncertainty, shyness with strangers as well as fatigability and asthenia. Yet harm avoidance has been linked with hypodopaminergic behaviors such as apathy, depression, anxiety, irritability, and hyperemotionality ( 44 – 46 ) as well as with PD ( 47 ). In addition, SPARK scores were strongly related with higher levels of depression and anxiety, and moderately associated with the level of apathy.…”

Section: Discussionmentioning

confidence: 99%

Embarrassment and Shame in People With Parkinson's Disease: A New Tool for Self-Assessment

et al. 2020

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Shame and embarrassment related to Parkinson's disease (PD) are rarely addressed in clinical practice nor studied in neuroscience research, partly because no specific tool exists to detect them in PD. Objective: To develop a self-applied assessment tool of shame and embarrassment specifically related to PD or its treatment, to promptly identify the presence and severity of these two emotions in PD. Methods: Identification and selection of relevant items were obtained from the collection of PD patients' opinions during support groups and interviews. Several further items were added following a literature review. Subsequently, a two-phase pilot study was performed for identification of ambiguous items and omissions, and to obtain preliminary data on acceptability, reliability, validity and relevance of the new scale (SPARK). Results: A total of 105 PD patients were enrolled in the study. Embarrassment was reported in 85% of patients, while shame was present in 26%. Fifteen percent of patients did not describe any shame or embarrassment. On average, the intensity of these two emotions was low with a marked floor effect in SPARK items and subscales. However, SPARK total score inter-individual variability was important (range 1-84 out of 99). Acceptability and quality of data were satisfactory with no floor or ceiling effects (2.9% each) or missing data. Internal consistency (Cronbach's alpha) was 0.94 for total score and 0.73-0.87 for subscales. The scale correlated ≥0.60 with instruments measuring related constructs. Content validity was satisfactory. SPARK total score strongly correlated with impaired health-related quality of life (r S = 0.81), the propensity to feel embarrassed or ashamed (r S = 0.68 and 0.66, respectively), and anxiety (r S = 0.72) and depression (r S = 0.63) levels. Moderate to high correlations were observed between SPARK total score and apathy (r S = 0.46) and a more pronounced personality trait directed toward harm avoidance (r S = 0.46). No significant differences in SPARK Fleury et al. Shame and Embarrassment in PD scores were found by sex, education level, PD duration, Hoehn and Yahr stages or PD phenotype. Conclusion: Preliminary analysis of psychometric properties suggests that SPARK could be an acceptable and reliable instrument for assessing shame and embarrassment in PD. SPARK could help healthcare professionals to identify and characterize PD-induced shame and embarrassment.

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“…All of these three variables are associated with creativity (Agnoli et al, 2016;De Fruyt et al, 2000;Hao et al, 2016;Perkins et al, 2015;Singh and Kaushik, 2015a). In particular, links to the dopaminergic system have been repeatedly described for extraversion (Cohen et al, 2005;Depue and Collins, 1999a;Golimbet et al, 2007;Lhommée et al, 2017;Rammsayer, 1998;Wacker et al, 2006) and neuroticism (emotional stability) (Barbato et al, 2012;Canli, 2008;Fischer et al, 1997;Tochigi et al, 2006). There is also some evidence for a relationship between fluency and dopamine (Murphy et al, 2013).…”

Section: /32mentioning

confidence: 95%

Modulations in resting state networks of subcortical structures linked to creativity

et al. 2019

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Creativity is a sine qua non ability for almost all aspects of everyday life. Although very profound behavioural models were provided by 21th century psychologists, the neural correlates of these personality features associated with creativity are largely unknown. Recent models suggest strong relationships between dopamine release and various creative skills. Herein, we employed functional connectivity analyses of resting-state functional magnetic imaging data in order to shed light on these neural underpinnings of creative aspects. For improved sensitivity, we performed the study at ultra-high magnetic field (7 Tesla). Seed regions were defined based on subcortical (ventral tegmental area/substantia nigra, nucleus caudatus) activation foci of a remote associates task (RAT). In addition, bilateral PCC was used as seed region to examine the default-mode network. Network strength across subjects was regressed against a battery of psychological variables related to creativity. Dopaminergic network variations turned out to be indicative for individual differences in creative traits. In this regard, the caudate network showed stronger connectivity in individuals with higher extraversion measures, while connectivity with the midbrain network was found increased with higher ideational behaviour and emotional stability.

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Personality, dopamine, and Parkinson's disease: Insights from subthalamic stimulation

Abstract: When subthalamic stimulation is applied in Parkinson's disease, significant changes in personality traits are observed, which may be related to postoperative tapering of dopaminergic treatment. © 2017 International Parkinson and Movement Disorder Society.

Cited by 30 publications

References 57 publications

Neurobiology and clinical features of impulse control failure in Parkinson’s disease

Neurobiology and clinical features of impulse control failure in Parkinson’s disease

Embarrassment and Shame in People With Parkinson's Disease: A New Tool for Self-Assessment

Modulations in resting state networks of subcortical structures linked to creativity

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