Importance: Many personality traits robustly correlate with BMI, but the existence and direction of causality are unclear. As personality traits also correlate with various other mental and physical health outcomes, understanding causality in these intersections is widely useful; understanding causality between BMI and personality specifically could inform weight management strategies (if personality influences BMI) or delineate mechanisms of personality development (if otherwise).Objective: To test the existence and direction of causal links between BMI and personality.Design: Two genetically informed analyses. In Mendelian randomization, an allele score for BMI was used to predict eating-specific and domain-general phenotypic personality scores, and allele scores for personality traits were used to predict phenotypic BMI. In Direction of Causation, twin data were used to infer the best-fitting causal model (personality influencing BMI, BMI influencing personality, reciprocal causation, or no causation).Setting: Cross-sectional data: molecular genetic data for Mendelian randomization, twin data for Direction of Causation.Participants: Mendelian randomization used Estonian Biobank data (N=3,541); Direction of Causation combined twin samples from five countries (N=5,424).Exposures: In Mendelian randomization, genetic propensity for BMI and the personality traits Neuroticism, Worry, and Depressive Affect was summarized in allele scores. In Direction of Causation, phenotypic BMI and phenotypic personality scores were treated as both exposures and outcomes. Phenotypic scores for domain-general and eating-specific personality were calculated by summing relevant questionnaire items weighted by their empirical association with BMI, maximizing statistical power.Main outcomes and measures: Phenotypic BMI and phenotypic personality scores.Results: The allele score for BMI predicted domain-general (β=0.05, 95% CI 0.01–0.08, P=.009) and eating-specific phenotypic personality score (β=0.05, 95% CI 0.01–0.08, P=.009). The allele score for Worry also predicted BMI (β=-0.07, 95% CI -0.10–-0.03, P<.001), while those for Neuroticism and Depressive Affect did not (P≥.358). In Direction of Causation, BMI similarly predicted domain-general (β=0.21, 95% CI 0.18–0.24, P<.001) and eating-specific personality (β=0.19, 95% CI 0.16–0.22, P<.001). In exploratory analyses, causal links between BMI and domain-general personality traits appeared reciprocal for higher-weight individuals (BMI>~25).Conclusions and Relevance: Results suggest an influence of BMI on personality. Maintaining or achieving normal-range weight may contribute to a more favorable personality profile, possibly relevant in mental health and general well-being.Supplement: Supplementary online content available at https://osf.io/meqxn/