Personality profile and its association with conversion to neurodegenerative disorders in idiopathic REM sleep behavior disorder

Abstract

Patients with Parkinson’s disease (PD) were described less extraverted and more neurotic. It remained unclear whether similar personality traits could be found in idiopathic rapid eye movement sleep behavior disorder (iRBD), a prodromal stage of PD, and could predict phenoconversion to neurodegenerative disorders. We aimed to investigate the personality profile and its association with future neurodegenerative phenoconversion in iRBD patients. One hundred and eighty-five video-polysomnography confirmed iRBD patients and 91 age- and sex-matched controls underwent personality assessment using the NEO five-factor inventory, and 171 iRBD patients were followed up. Our results showed that iRBD was marginally negatively associated with extraverted personality trait (B = −0.28, 95% confidence interval (CI) = −0.55, −0.001). During a median follow-up of 5.9 years, 47 iRBD patients (27.5%) had phenoconversion. More neurotic (adjusted hazard ratio (HR) = 2.0, 95% CI = 1.3, 3.1) and less extraverted personality traits (adjusted HR = 0.53, 95% CI = 0.36, 0.77) were associated with an increased risk of phenoconversion in iRBD patients. Our findings suggest that personality profile may be a potential prodromal marker of iRBD.

Altered Impulsivity Across Drug‐Naïve Parkinsonism, Isolated Rapid Eye Movement Sleep Behavior Disorder, and Their High‐Risk Relatives

“…23,24 Lifetime psychiatric disorders were assessed via a structured interview based on the DSM-IV and further supplemented by clinical records. 25,26 Current medications usage, including antidepressants, antipsychotics, and antiepileptics, were collected during the interview and supplemented by clinical records.…”

“…DEBs were evaluated by the Diagnostic Interview for Sleep Patterns and Sleep Disorders and supplemented by the RBD questionnaire‐Hong Kong (factor 2 score ≥8) 23,24 . Lifetime psychiatric disorders were assessed via a structured interview based on the DSM‐IV and further supplemented by clinical records 25,26 . Current medications usage, including antidepressants, antipsychotics, and antiepileptics, were collected during the interview and supplemented by clinical records.…”