Personality profiles and pulmonary function of children with sighing dyspnoea

Wong, Kin-Sun; Huang, Yu‐Shu; Huang, Yu-Hsuan; Chiu, Chih‐Yung

doi:10.1111/j.1440-1754.2007.01059.x

Cited by 10 publications

(16 citation statements)

References 27 publications

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“…1) is a nitrogen-rich chemical implicated in the pet and human food recalls in 2007 [1,2] and in the global food safety scares in 2008 involving milk and milk-derived products [3][4][5]. In those food safety incidents, melamine was intentionally added to foods and animal feed to boost the protein content which was measured by the Kjeldahl method [6,7]. In late 2008, trace amount of melamine and its analogue, cyanuric acid (1,3,5-triazine-2,4,6-triol) ( Fig.…”

Section: Introductionmentioning

confidence: 99%

Potential of SERS for rapid detection of melamine and cyanuric acid extracted from milk

Liu

Lin

2010

Sens. & Instrumen. Food Qual.

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Melamine, a nitrogen-rich chemical, was implicated in the pet and human food recalls in 2007 and in the global food safety scares in 2008 involving milk and other milk-derived products. In this study, we investigated the feasibility of using surface-enhanced Raman spectroscopy (SERS) coupled with SERS-active gold substrates for rapid detection of trace amounts of melamine and its analogue (that is, cyanuric acid) in liquid milk. Raman signals of tested samples were significantly enhanced by SERS. The identification limit for SERS using gold substrate can reach 2 ppm of melamine in liquid milk. Partial least squares (PLS) models were established for the quantification of melamine in liquid milk by SERS: R = 0.90, RMSEP = 1.48 9 10 -5 . Our results demonstrate that rapid detection of melamine in milk can be achieved by SERS; while detection of cyanuric acid in milk remains a challenging task due to rapid enol-keto tautomerism of cyanuric acid. The SERS method is faster and simpler than other traditional methods, and requires minimum sample preparation. These results demonstrate that SERS could be used to detect food contaminants such as melamine in foods and food ingredients quickly and accurately.

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Section: Introductionmentioning

confidence: 99%

Potential of SERS for rapid detection of melamine and cyanuric acid extracted from milk

Liu

Lin

2010

Sens. & Instrumen. Food Qual.

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“…A wide spectrum of diseases can cause dyspnea in the adult population, among which chronic heart failure and interstitial lung diseases are the leading causes of dyspnea, but are uncommon in children. Few studies have been done on the causes of sighing dyspnea in children 1–7 . Functional and behavior changes have been suggested to be the most prevalent cause in adolescents and young children, 1–3 but obstructive pulmonary diseases should be excluded first 11 .…”

Section: Discussionmentioning

confidence: 99%

“…Normal volunteers from children of staff were invited to undertake pulmonary function tests if they had no previous history of allergy, wheezing, chronic coughing or chronic cardiopulmonary diseases. Each subject underwent baseline spirometry measurement in a standing position with the use of nose clip and bacterial filter (MicroGard, Sensor Medics, Yorba Linda, CA, USA) and attached mouthpiece according to standard guidelines 5,8,9 . Flow volume loops were displayed after each maneuver, along with FVC, forced expiratory volume in 1 s (FEV 1 ), and forced expiratory flow between 25% and 75% of the FVC (FEF 25–75 ).…”

Section: Methodsmentioning

confidence: 99%

“…Flow volume loops were displayed after each maneuver, along with FVC, forced expiratory volume in 1 s (FEV 1 ), and forced expiratory flow between 25% and 75% of the FVC (FEF 25–75 ). The highest values were recorded and expressed as a percentage of the predicted normal value for age, sex and height without correction for ethnicity 5,10 . The post‐bronchodilator (post‐BD) FVC, FEV 1 , FEV 1 /FVC, FEF 25–75 were repeated after inhalation of 400 μg albuterol, and a BD response was considered positive for FEV 1 ≥12%.…”

Section: Methodsmentioning

confidence: 99%

“…The mechanisms of dyspnea remain elusive, but may involve complex interactions of the central nervous system, mechanoreceptors in the upper airway, and lungs as well as in the thoracic cavity 4 . Sighing dyspnea in children has rarely been studied systematically, and the cause of sighing remains unknown 5–7 . In the present study children under 18 years of age who visited the pediatric chest clinic at Chang Gung Children’s Hospital because of deep inspiration with associated breathing difficulty, but no accompanying increase of respiratory rate and exercise intolerance were recruited and studied.…”

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confidence: 99%

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Plethysmographic lung volumes in children with sighing dyspnea

Wong¹,

Chiu²,

Huang³

et al. 2009

Pediatrics International

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RV and RV/TLC were higher in children with sighing dyspnea that were not measured by spirometry, but TLC and FRC(pleth) were not increased. The causal link between dysfunctional breathing patterns and changes in static lung volumes was not able to be determined in the present study. The possibility of heterogeneity of patients with sighing dyspnea obscures the significance of lung volume discrepancy in this population; further subdivision of children with sighing dyspnea in a larger cohort of patients is required.

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“Psychological characteristics of functional respiratory disorders in children and adolescents—Pilot study”

Niggemann

Maas²,

Suerbaum³

et al. 2022

Pediatric Pulmonology

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Background Aim of our prospective, multicenter, nonrandomized study was to identify characteristic features and similarities of patients with functional respiratory disorders regarding socio‐familial and behavioral aspects, in comparison with controls in a cross‐sectional analysis using standardized psychological questionnaires. Furthermore, we investigated the longitudinal outcome of symptoms, effects of primary interventions and the stability of psychological traits 6 months after diagnosis and primary intervention. Methods Initially, 106 patients (68 females, 27 males) and 58 controls (33 females, 25 males) were recruited for the study. Mean age was 12.6 years in patients and 11.9 years in controls. Results The child behavior checklist (CBCL) showed significantly increased scores for anxious/depressed (p = 0.002) and schizoid/obsessive (p = 0.001) behavior in patients. A trend was evident for internalizing behavior (p = 0.009) and for a higher total score (p = 0.008). In the self‐assessment youth self‐report (YSR), there was a trend towards higher values for anxious/depressed behavior in patients (p = 0.06) and towards more externalizing behavior (p = 0.029) in the control group. After 6 months, 31% of the patients were free of symptoms, 42% had improved. For themselves, parents reported a decreased burden from 56% to 23% (p < 0.001) and decreased impairment from 57% to 30% (p < 0.008). For their children, parents reported a decrease from 45% to 16% (p < 0.0001) and from 74% to 37% (p < 0.0001), respectively. A longitudinal comparison from T1 to T2 showed no statistically significant changes in all three psychological questionnaires (CBCL, YSR, and SOMS‐KJ). Conclusions In summary, we show that patients with functional respiratory disorders differ from healthy subjects, with internalizing behavior being a characteristic trait. The outcome in terms of symptoms, perceived psycho‐familial burden and impairment after 6 months is encouraging. However, we are aware that our preliminary data offer thought‐provoking impulses rather than firm findings.

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Personality profiles and pulmonary function of children with sighing dyspnoea

Abstract: The CBCL/4-18 scores of children with sighing dyspnoea were not significant different from age-matched healthy children and a heightened anxiety score was not confirmed in this study. Office spirometric values in patients with sighing dyspnoea were normal.

Cited by 10 publications

References 27 publications

Potential of SERS for rapid detection of melamine and cyanuric acid extracted from milk

Potential of SERS for rapid detection of melamine and cyanuric acid extracted from milk

Plethysmographic lung volumes in children with sighing dyspnea

“Psychological characteristics of functional respiratory disorders in children and adolescents—Pilot study”

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