Objective: This study aimed to determine whether there is an association between the occurrence of sexual dysfunction in women in postmenopausal women with depressive symptoms. Method: cross sectional study of 64 women aged 40 to 65 years old. To achieve the objective of the research we used a demographic questionnaire, the Beck Depression Inventory and theSexual Function Index Female (FSFI). Results: The median age of these women was 53 (50-58) years. Regarding education: 51.56% had primary education, 43.75% had high school and only 4.69% have higher education. Statistical analysis showed no significant association between sexual dysfunction and depressive symptoms (p=0.192); between depression and the item satisfaction FSFI showed statistically significant with p=0.021. Conclusion: This study demonstrated that the sexual dysfunction of women after menopause is not significantly associated with depressive symptoms. In the association between depression and the FSFI domains of instrument, there was a significant association only for the item satisfaction.