Aim: To investigate the relationship between generic and condition specific (CS) quality of life (QoL), general psychological wellbeing and personality in patients with tooth wear. Materials and Methods: Ethical approval was granted (REC:10/H0709/21). Patients 18-70 years with tooth wear completed the Oral Impacts on Daily Performances (OIDP) quality of life questionnaire, the NEO-FFI Personality questionnaire, and the General Health Questionnaire-12 (GHQ). Tooth wear was measured with the Basic Erosive Wear Examination (BEWE).Results: 102 subjects were recruited. Increased BEWE scores were correlated with older age, and worse generic, and CS related QoL. Increased Neuroticism was correlated to increased generic and CS-OIDP scores; generic and CS eating scores; CS smiling score and CS carrying out major work scores. Increased GHQ scores were positively correlated with increased generic and CS-OIDP scores; generic and CS-eating scores; CS-speaking scores; generic and CScleaning scores; generic relaxing scores, generic and CS-smiling scores and generic emotional state score (p=<0.05). Multivariable linear regression analyses showed thatincreasedNeuroticism and decreased GHQ both had an independent effect on generic and CS-OIDP scores when adjusted for tooth wear severity (p<0.05). Conclusion: Quality of life perception is complex, and was not only affected by worsening levels of tooth wear.