Personalized Bacteria Loaded with Autoantigens for the Enhancement of Tumor Immunotherapy

Wu, Chenhu; Wang, He; Chen, Yue; Cai, Jie; Zeng, Fanjun; Lu, Zi-Dong; Wang, Jilong

doi:10.1002/adhm.202203026

Cited by 9 publications

(3 citation statements)

References 40 publications

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“… 157 Then, engineered Salmonella (EnS) was encapsulated in PDA@CL (EnS@PDA@CL). 158 In animal experiments, the quantities of DCs and CD8 T cells in the EnS@PDA@CL group were almost three times higher than in the PBS group, verifying that EnS@PDA@CL intensively promoted antigen cross‐presentation and subsequent CD8 T cell stimulation by DCs.…”

Section: Advancing Solid Tumor Therapeutics: Applications Of Nanomate...mentioning

confidence: 78%

“…The tumor cell lysate‐coated polydopamine nanoparticles (PDA@CL) were designed to transfer tumor‐associated antigens (TAAs) precisely, alleviating the restricted activation of CD8 T cells in the TME due to insufficient antigen presentation by DCs 157 . Then, engineered Salmonella (EnS) was encapsulated in PDA@CL (EnS@PDA@CL) 158 . In animal experiments, the quantities of DCs and CD8 T cells in the EnS@PDA@CL group were almost three times higher than in the PBS group, verifying that EnS@PDA@CL intensively promoted antigen cross‐presentation and subsequent CD8 T cell stimulation by DCs.…”

Section: Advancing Solid Tumor Therapeutics: Applications Of Nanomate...mentioning

confidence: 99%

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Nanomaterial‐assisted oncolytic bacteria in solid tumor diagnosis and therapeutics

Zeng,

Chen,

Chen

2024

Bioengineering & Transla Med

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Cancer presents a formidable challenge in modern medicine due to the intratumoral heterogeneity and the dynamic microenvironmental niche. Natural or genetically engineered oncolytic bacteria have always been hailed by scientists for their intrinsic tumor‐targeting and oncolytic capacities. However, the immunogenicity and low toxicity inevitably constrain their application in clinical practice. When nanomaterials, characterized by distinctive physicochemical properties, are integrated with oncolytic bacteria, they achieve mutually complementary advantages and construct efficient and safe nanobiohybrids. In this review, we initially analyze the merits and drawbacks of conventional tumor therapeutic approaches, followed by a detailed examination of the precise oncolysis mechanisms employed by oncolytic bacteria. Subsequently, we focus on harnessing nanomaterial‐assisted oncolytic bacteria (NAOB) to augment the effectiveness of tumor therapy and utilizing them as nanotheranostic agents for imaging‐guided tumor treatment. Finally, by summarizing and analyzing the current deficiencies of NAOB, this review provides some innovative directions for developing nanobiohybrids, intending to infuse novel research concepts into the realm of solid tumor therapy.

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Section: Advancing Solid Tumor Therapeutics: Applications Of Nanomate...mentioning

confidence: 78%

Section: Advancing Solid Tumor Therapeutics: Applications Of Nanomate...mentioning

confidence: 99%

Nanomaterial‐assisted oncolytic bacteria in solid tumor diagnosis and therapeutics

Zeng,

Chen,

Chen

2024

Bioengineering & Transla Med

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“…The field of cancer vaccines has seen significant advancements in recent years, with numerous studies focusing on different aspects of vaccine development and application [ 8 – 12 ]. These advances have been facilitated by the exploration of various types of cancer vaccines, including those targeting viral antigens, neoantigens, and other tumor-specific antigens [ 13 – 16 ].…”

Section: Introductionmentioning

confidence: 99%

Cancer Vaccines Designed Based the Nanoparticle and Tumor Cells for the Treatment of Tumors: A Perspective

Wu,

2024

IET Nanobiotechnology

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Cancer vaccines based on tumor cell components have shown promising results in animal and clinical studies. The vaccine system contains abundant tumor antigen components, which can activate the immune system by antigens. However, their efficacy has been limited by the inability of antigens delivery, which are the core components of vaccines, further fail to be presented and activation of effective cells. Nanotechnology offers a novel platform to enhance the immunogenicity of tumor-associated antigens and deliver them to antigen-presenting cells (APCs) more efficiently. In addition, nanotreatment of tumor cells derivate active ingredients could also help improve the effectiveness of cancer vaccines. In this review, we summarize recent advances in the development of cancer vaccines by the combination of nanotechnology and tumor-based ingredients, including liposomes, polymeric nanoparticles, metallic nanoparticles, virus-like particles and tumor cells membrane, tumor lysate, and specific tumor antigens. These nanovaccines have been designed to increase antigen uptake, prolong antigen presentation, and modulate immune responses through codelivery of immunostimulatory agents. We also further discuss challenges and opportunities in the clinical translation of these nanovaccines.

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Surface Engineering on Bacteria for Tumor Immunotherapy: Strategies and Perspectives

Fu,

He,

et al. 2024

Adv Funct Materials

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Bacteria have garnered significant attention in tumor immunotherapy recently years, owing to their immune‐activating properties, ease of genetic manipulation, and colonization abilities. In order to further enhance the safety, efficacy, and clinical translation potential of bacterial therapy, and to endow bacteria with additional functions, modifications or engineering of bacterial surfaces have emerged as a current research hotspot. This review systematically summarizes the primary methods and strategies for bacterial surface modification and engineering, including chemical alteration, physical modification, and bio‐modification. Subsequently, it is delve into the roles of these techniques in enhancing bacterial tumor immunotherapy, such as improving immunotherapeutic efficacy and reducing toxic side effects, and elucidate the underlying mechanisms. Finally, the current challenges faced in this field are deeply explored, and potential solutions for the future are presented. This work offers a comprehensive overview of the advancements in the new generation of bacterial surface modification techniques and their implications in bacterial‐based tumor immunotherapy.

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Personalized Bacteria Loaded with Autoantigens for the Enhancement of Tumor Immunotherapy

Cited by 9 publications

References 40 publications

Nanomaterial‐assisted oncolytic bacteria in solid tumor diagnosis and therapeutics

Nanomaterial‐assisted oncolytic bacteria in solid tumor diagnosis and therapeutics

Cancer Vaccines Designed Based the Nanoparticle and Tumor Cells for the Treatment of Tumors: A Perspective

Surface Engineering on Bacteria for Tumor Immunotherapy: Strategies and Perspectives

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