Personalized Cancer Medicine

Extreme Expression of DNA Repair Protein Apurinic/Apyrimidinic Endonuclease 1 (APE1) in Human Breast Cancer As Measured by Liquid Chromatography and Isotope Dilution Tandem Mass Spectrometry

“…Moreover, APE1 polymorphisms are associated with the disposition to cancer. , APE1 expression is upregulated or dysregulated in many human cancers. In general, APE1 overexpression is associated with many adverse effects, including resistance to therapy, prolonged therapeutic response, and lower survival rates. ,− DNA repair and redox regulatory activities of APE1 affect various signaling pathways, suggesting that cancer cells may be addicted to APE1 functions for survival . Many aspects of APE1 as outlined above make it a well-justified target in cancer for development of inhibitors as anticancer drugs.…”