Personalized Cancer Medicine: From Molecular Diagnostics to Targeted Therapy with Natural Products

Efferth, Thomas

doi:10.1055/s-0030-1249937

Cited by 29 publications

(13 citation statements)

References 101 publications

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“…Cluster analyses of microarray data have been frequently applied during the past decade to predict sensitivity or resistance of tumors towards anticancer drugs (45)(46)(47). Gene expression profiles may therefore be valuable for therapy planning in settings of personalized medicine: If a tumor's response to certain drugs can be predicted by gene expression profiling prior to chemotherapy, the most effective drugs could be chosen (48)(49)(50). On the other hand, significant correlations between gene expressions and cellular responsiveness to a cytotoxic compound do not necessarily imply that such genes indeed represent mechanistic causes of drug resistance.…”

Section: Discussionmentioning

confidence: 99%

Laurus nobilisL. Seed Extract Reveals Collateral Sensitivity in Multidrug-Resistant P-Glycoprotein-Expressing Tumor Cells

Saab

Guerrini

Zeino

et al. 2015

Nutrition and Cancer

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The frequent failure of standard cancer chemotherapy requires the development of novel drugs capable of killing otherwise drug-resistant tumors. Here, we have investigated a chloroform extract of Laurus nobilis seeds. Fatty acids and 23 constituents of the volatile fraction were identified by gas chromotography/flame ionization detection (GC/FID) and gas chromatography/mass spectrometry (GC/MS), in good agreement with (1)H NMR (nuclear magnetic resonance) spectrum. Multidrug-resistant P-glycoprotein-expressing CEM/ADR5000 leukemia cells were hypersensitive (collaterally sensitive) toward this extract compared to drug-sensitive CCRF-CEM cells, whereas CEM/ADR5000 cells were 2586-fold resistant to doxorubicin as control drug. Collateral sensitivity was verified by measurement of apoptotic cells by flow cytometry. The log10IC50 values of 3 compounds in the extract (limonene, eucalyptol, oleic acid) did not correlate with mRNA expression of the P-glycoprotein-coding ABCB1/MDR1 gene and accumulation of the P-glycoprotein substrate rhodamine in the NCI panel of tumor cell lines. A microarray-based profile of 20 genes predicted resistance to doxorubicin and 7 other anticancer drugs involved in the multidrug resistance phenotype but not to limonene, eucalyptol and oleic acid. In conclusion, our results show that Laurus nobilis seed extract is suitable to kill multidrug-resistant P-glycoprotein expressing tumor cells.

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Section: Discussionmentioning

confidence: 99%

Laurus nobilisL. Seed Extract Reveals Collateral Sensitivity in Multidrug-Resistant P-Glycoprotein-Expressing Tumor Cells

Saab

Guerrini

Zeino

et al. 2015

Nutrition and Cancer

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“…The demand for traditional medicines both in developing as well as industrialized countries makes it mandatory to investigate the scientific basis of herbal remedies [8][9][10][11][12][13]. Evidence-based medicine is thought to be a standard for modern academic medicine, although the use of not few western-style drugs is more experience-based than evidencebased.…”

Section: Traditional Medicine Todaymentioning

confidence: 99%

Traditional Medicine with Plants Present and Past

Efferth

Greten

2014

Medicinal Aromatic Plants

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“…Today, translational research and pharmacogenetics generate data to tailor the treatment to the individual patient, and targeted therapies allow a more specific tumor therapy. These new research activities brought forward the development of targeted therapies and strategies to overcome drug resistance with natural products like Chinese Medicine [27]. In its longstanding history, Chinese Medicine has always been centered around individualized treatment with regular adaptation to the changing course of disease.…”

Section: Personalized Medicinementioning

confidence: 99%

“…In today's Western Medicine, we usually have to deliver one or more treatment cycles to judge the effectiveness of the treatment. New predictive protein markers may help in the future to adapt the treatment earlier to the individual situation [27].…”

Section: Personalized Medicinementioning

confidence: 99%

Western and Chinese Medicine in Oncology and Hematology

Lampe

Halle²,

Freund

2011

Forsch Komplementmed

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Based on a conclusive theoretical background, both Western and Chinese Medicine have developed diagnostic and therapeutic procedures which lead to reproducible treatment results. Whilst Western Medicine focuses on a most precise diagnosis of tumor histology and the extend of dissemination, Chinese Medicine has developed tools for a functional diagnoses of disturbed body functions. And as Western Medicine aims at producing most specific targeted drugs, Chinese Medicine intends to stabilize disturbed body functions mostly with decoctions. A combined treatment which synergizes specific tumor attack and patient stabilization seems promising. However, the different cultural backgrounds have led to different standards of evaluation. Although the scientific evaluation of Chinese Medicine has led to the development of new drugs, the majority of treatments with decoctions are not evaluated according to the accepted standards. As of today, modern research could only occasionally find explanations for the longstanding experience, but new research ideas have resulted from this confrontation. The approach of combining standard treatments with Chinese treatment concepts only started a few decades ago. The experiences and promising results from smaller studies stand against possible risks of unknown interactions with proven treatment concepts. Pharmacokinetic and clinical studies will be necessary to evaluate these combined treatment concepts. In everyday life, Western and Chinese Medicine should be used in sequence, whereas in studies and special situations the combined approach should be applied to offer possible benefits without causing unnecessary risks to the patients.

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Personalized Cancer Medicine: From Molecular Diagnostics to Targeted Therapy with Natural Products

Cited by 29 publications

References 101 publications

Laurus nobilisL. Seed Extract Reveals Collateral Sensitivity in Multidrug-Resistant P-Glycoprotein-Expressing Tumor Cells

Laurus nobilisL. Seed Extract Reveals Collateral Sensitivity in Multidrug-Resistant P-Glycoprotein-Expressing Tumor Cells

Traditional Medicine with Plants Present and Past

Western and Chinese Medicine in Oncology and Hematology

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Personalized Cancer Medicine: From Molecular Diagnostics to Targeted Therapy with Natural Products

Cited by 29 publications

References 101 publications

Laurus nobilisL. Seed Extract Reveals Collateral Sensitivity in Multidrug-Resistant P-Glycoprotein-Expressing Tumor Cells

Laurus nobilisL. Seed Extract Reveals Collateral Sensitivity in Multidrug-Resistant P-Glycoprotein-Expressing Tumor Cells

Traditional Medicine with Plants  Present and Past

Western and Chinese Medicine in Oncology and Hematology

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Product

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Traditional Medicine with Plants Present and Past