2019
DOI: 10.1101/2019.12.19.883108
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Personalized genealogical history inferred from biobank-scale IBD segments

Abstract: When modern biobanks collect genotype information for a significant fraction of a population, dense genetic connections of a person can be traced using identity by descent (IBD) segments. These connections offer opportunities to characterize individuals in the context of the underlying populations. Here, we conducted an individual-centric analysis of IBDs among the UK Biobank participants that represent 0.7% of the UK population. On average, one UK individual shares IBDs over 5 cM with 14,000 UK Biobank partic… Show more

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Cited by 3 publications
(3 citation statements)
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“…Instead of enumerating all ROH diplotypes, we focused on those that are sufficiently long and frequent. Such ROH diplotypes are of interest because they are at the extreme of distribution: the chance of ROH is determined by the chance of a pair of mates having IBD, and such chance and also the length of IBD segments will decay quickly in outbred populations, as supported by population genetics theory ( Thompson, 2013 ; Donnelly, 1983 ) and real-world data ( Ralph and Coop, 2013 ; Naseri et al, 2019b ). However, little is known about such ROH diplotypes because no existing methods can efficiently find them.…”
Section: Introductionmentioning
confidence: 99%
“…Instead of enumerating all ROH diplotypes, we focused on those that are sufficiently long and frequent. Such ROH diplotypes are of interest because they are at the extreme of distribution: the chance of ROH is determined by the chance of a pair of mates having IBD, and such chance and also the length of IBD segments will decay quickly in outbred populations, as supported by population genetics theory ( Thompson, 2013 ; Donnelly, 1983 ) and real-world data ( Ralph and Coop, 2013 ; Naseri et al, 2019b ). However, little is known about such ROH diplotypes because no existing methods can efficiently find them.…”
Section: Introductionmentioning
confidence: 99%
“…Ideally, IBD estimates can be obtained from phased haplotypes; this means each diploid individual in the data set is represented by two sequences each of which consists of alleles inherited from a single parent. IBD estimates that are phase aware can improve relationship and pedigree inference (Ramstetter et al 2017, 2018; Williams et al 2020), enable health and trait inheritance to be traced (Browning and Thompson 2012; Lin et al 2013; Vacic et al 2014; Henden et al 2016; Belbin et al 2017; Yang et al 2019; Henden et al 2019; Finke et al 2020), and increase the accuracy of many other inferences regarding demographic history and genetic ancestry (Palamara et al 2012; Ralph and Coop 2013; Palamara and Pe’er 2013; Martin et al 2018; Pathak et al 2018; Browning et al 2018; Naseri et al 2019c).…”
Section: Introductionmentioning
confidence: 99%
“…Instead of enumerating all ROH diplotype, we focused on those that are sufficiently long and frequent. Such ROH diplotypes are of interest because they are at the extreme of distribution: the chance of ROH is determined by the chance of a pair of mates having IBD, and such chance and also the length of IBD segments will decay quickly in outbred populations, as supported by population genetics theory 17,18 and real world data 19,20 . However, little is known about such ROH diplotypes because no existing methods can efficiently find them.…”
Section: Introductionmentioning
confidence: 99%