Personalized Genomic Analyses for Cancer Mutation Discovery and Interpretation.

Anagnostou, Valsamo; Jones, Siân; Lytle, Karli; Parpart-Li, Sonya; Nesselbush, Monica; Adleff, Vilmos; Riley, David R.; Shukla, Manish; Chesnick, Bryan; Kadan, Michael J.; Papp, Eniko; Galens, Kevin; Murphy, Derek; Zhang, Theresa; Kann, Lisa; Sausen, Mark; Angiuoli, Samuel; Díaz, Luis A.; Velculescu, Victor E.

doi:10.1200/jco.2015.33.15_suppl.1529

Cited by 2 publications

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“…Our workforce requirements model takes this dynamic into account through Pathway 6 ( Figure 1 ), which in the base case assumes that 11.5% of new cancer patients receive tumour testing and P/LP germline mutations are detected in 3% of those patients, which leads to Pathway 6 only accounting for about 1% of the caseload and <1% of FTE requirements. However, while the 11.5% tumour testing rate was calculated based on comprehensive country-wide data from France [ 24 ], it reflects practice as of 2017, and the 3% germline variant estimate is from 2015 [ 25 ]. If either statistic increases by 2030 (which appears likely based on more recent studies [ 23 ]), the impact of germline P/LP variants detected through somatic testing on overall hereditary cancer clinics’ workforce requirements could increase significantly.…”

Section: Discussionmentioning

confidence: 99%

Workforce Implications of Increased Referrals to Hereditary Cancer Services in Canada: A Scenario-Based Analysis

Dragojlovic,

Borle,

Kopac

et al. 2023

Current Oncology

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Over the last decade, utilization of clinical genetics services has grown rapidly, putting increasing pressure on the workforce available to deliver genetic healthcare. To highlight the policy challenges facing Canadian health systems, a needs-based workforce requirements model was developed to determine the number of Canadian patients in 2030 for whom an assessment of hereditary cancer risk would be indicated according to current standards and the numbers of genetic counsellors, clinical geneticists and other physicians with expertise in genetics needed to provide care under a diverse set of scenarios. Our model projects that by 2030, a total of 90 specialist physicians and 326 genetic counsellors (1.7-fold and 1.6-fold increases from 2020, respectively) will be required to provide Canadians with indicated hereditary cancer services if current growth trends and care models remain unchanged. However, if the expansion in eligibility for hereditary cancer assessment accelerates, the need for healthcare providers with expertise in genetics would increase dramatically unless alternative care models are widely adopted. Increasing capacity through service delivery innovation, as well as mainstreaming of cancer genetics care, will be critical to Canadian health systems’ ability to meet this challenge.

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Section: Discussionmentioning

confidence: 99%

Workforce Implications of Increased Referrals to Hereditary Cancer Services in Canada: A Scenario-Based Analysis

Dragojlovic,

Borle,

Kopac

et al. 2023

Current Oncology

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The Relevance (and Irrelevance) of Questions of Personhood (and Mindedness) to the Abortion Debate

Johnson

2019

SHERM

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Disagreements about abortion are often assumed to reduce to disagreements about fetal personhood (and mindedness). If one believes a fetus is a person (or has a mind), then they are “pro-life.” If one believes a fetus is not a person (or is not minded), they are “pro-choice.” The issue, however, is much more complicated. Not only is it not dichotomous—most everyone believes that abortion is permissible in some circumstances (e.g. to save the mother’s life) and not others (e.g. at nine months of a planned pregnancy)—but scholars on both sides of the issue (e.g. Don Marquis and Judith Thomson) have convincingly argued that fetal personhood (and mindedness) are irrelevant to the debate. To determine the extent to which they are right, this article will define “personhood,” its relationship to mindedness, and explore what science has revealed about the mind before exploring the relevance of both to questions of abortion’s morality and legality. In general, this article does not endorse a particular answer to these questions, but the article should enhance the reader’s ability to develop their own answers in a much more informed way.

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Personalized Genomic Analyses for Cancer Mutation Discovery and Interpretation.

Cited by 2 publications

References 0 publications

Workforce Implications of Increased Referrals to Hereditary Cancer Services in Canada: A Scenario-Based Analysis

Workforce Implications of Increased Referrals to Hereditary Cancer Services in Canada: A Scenario-Based Analysis

The Relevance (and Irrelevance) of Questions of Personhood (and Mindedness) to the Abortion Debate

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