In the digital age, the personalization of learning has become a critical priority in education. This article delves into the cutting-edge of educational innovation by exploring the essential role of ontology-based knowledge representation in transforming the educational experience. This research stands out for its significant and distinctive contribution to improving the personalization of learning. For this, concrete examples of use cases are presented in various academic fields, from formal education to corporate training and online learning. It is identified how ontologies capture and organize knowledge semantically, allowing the intelligent adaptation of content, the inference of activity and resource recommendations, and the creation of highly personalized learning paths. In this context, the novelty lies in the innovative approach to designing educational ontologies, which exhaustively considers different use cases and academic scenarios. Additionally, we delve deeper into the design decisions that support the effectiveness and usefulness of these ontologies for effective learning personalization. Through practical examples, it is illustrated how the implementation of ontologies transforms education, offering richer educational experiences adapted to students’ individual needs. This research represents a valuable contribution to personalized education and knowledge management in contemporary educational environments. The novelty of this work lies in its ability to redefine and improve the personalization of learning in a constantly evolving digital world.