Personalized Management Approach for OSA

Incorporating polysomnography into obstructive sleep apnoea phenotyping: moving towards personalised medicine for OSA

“…The phenotyping of patients with OSA has been tackled in several different ways. One strategy has been to address the anatomical and physiological traits underlying OSA occurrence and the range of severity 4. The pathophysiological causes of OSA vary considerably between patients.…”

“…The pathophysiological causes of OSA vary considerably between patients. Determining the respective contributions of upper airway anatomy and collapsibility, arousal threshold and loop gain (ventilator drive) will help to predict which therapeutic modality would be beneficial to the appropriately targeted patient subgroups 4. Another topic has been to define distinct OSA clinical phenotypes.…”

Advanced polysomnographic analysis for OSA: A pathway to personalized management?

“…Other individual differences include the effect of OSA on susceptibility to morbidities and the effect of treatment on health outcomes. The variable pathways, symptoms and health outcomes create opportunities for personalized care …”

“…The variable pathways, symptoms and health outcomes create opportunities for personalized care. 4 The polysomnogram (PSG), first reported in 1974, 5 remains the gold-standard diagnostic test. The PSG contains multiple sensors with simultaneous recording of airflow, blood oxygen levels, respiratory effort, electrocardiogram (ECG), electroencephalogram (EEG), electromyogram (EMG) and electrooculogram (EOG).…”

Diagnostic criteria for obstructive sleep apnea: time for reappraisal

“…This call is reinforced by the recognition of OSAS as an important contributing factor in motor vehicle accidents and the recent introduction of Europe-wide regulations regarding fitness to drive for patients with the disorder (17). Thus, a personalised approach to the diagnosis and management of patients with OSAS is most appropriate (18), preferably by a clinician with experience and expertise in managing OSAS. This approach is most likely to achieve successful results in terms of patient satisfaction, optimum choice of therapy, and successful outcomes.…”