Personalized medicine: current status and prospects

Nasadyuk, C. M.; Sklyarov, Alexander

doi:10.22494/cot.v7i1.96

Cited by 1 publication

(1 citation statement)

References 19 publications

(43 reference statements)

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“…Antimicrobial peptides have recently gathered significant attention as an emerging source of potential antibiotics, due to the swift emergence of multidrug-resistant bacteria and a dwindling antibiotic pipeline [35]. Since the vast majority of antimicrobial peptides are long, comprised of more than 10 amino acids, resulting in significant production costs for their synthesis while simultaneously displaying metabolic instability and relatively poor pharmacological profiles, efforts have been shifted to shorter molecules and the development of new peptidomimetic approaches [35].…”

Section: Application Of Short Peptide Sequences In Medicinementioning

confidence: 99%

Short peptide sequences: current knowledge and future prospects

Nasadyuk¹

2021

Ukr.Biochem.J.

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According to modern knowledge, the biological effect of many peptides is mediated by their shortchain fragments -oligopeptides -ranging from 2 to 20 amino acids and the activity of short peptides often significantly exceeds the activity of the peptide precursor. Aim of the review was to summarize the uptodate data on the stability of short peptide sequences, mechanisms of cell penetration, interaction with cell receptors, biological effects and approaches to clinical application. Stability of short peptides is mediated by their structure and molecular weight. Some di-/tripeptides were reported to be able to permeate through intestinal membranes in their intact forms via peptide transporter systems, while others are vulnerable to protease degradation. although pinocytosis is presumed to be the main mechanism how short peptide sequences enter the cell, some lipophilic oligopeptides were shown to penetrate the cell membrane by the same mechanism as steroid or thyroid hormones and specific extracellular receptors were also described. Low-weighing oligopeptides realize their effect on the cell, chromosomal, genome and molecular levels. The advantages of oligopeptides include oral availability (for low weight compounds), low immunogenicity, high tissue specificity, faster biological effect, better cost efficiency and environmental friendliness of their synthesis. Hence, short peptide sequences are regarded as promising candidates for pharmacotherapy, cell cultures and drug delivery purposes.

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Section: Application Of Short Peptide Sequences In Medicinementioning

confidence: 99%

Short peptide sequences: current knowledge and future prospects

Nasadyuk¹

2021

Ukr.Biochem.J.

View full text Add to dashboard Cite

show abstract

Personalized medicine: current status and prospects

Cited by 1 publication

References 19 publications

Short peptide sequences: current knowledge and future prospects

Short peptide sequences: current knowledge and future prospects

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