Personalized medicine in psychiatry

Wium‐Andersen, Ida Kim; Vinberg, Maj; Kessing, Lars Vedel; McIntyre, Roger S.

doi:10.1080/08039488.2016.1216163

Cited by 58 publications

(43 citation statements)

References 97 publications

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“…31,36,46,49,50,[58][59][60] Our research data provide further evidence that the treatment decisions for the individual schizophrenic patients are more correct if they are guided by the objectively measured LMPs. 4,5 Such an objective and quantitative evaluation at a single-patient level is in line with the modern tendency for personalized 36,61,62 and precision 63,64 medicine in the psychiatric neuroscience research, aimed at replacing the traditional categorical diagnostic approach with a more dimensional one 64-68 that looks for "theranostic" 69 rather than for diagnostic biomarkers. 67,68 It is interesting to note that just in the last few years the motor dimension was proposed to be included in the translational psychiatric neuroscience research.…”

Section: Clinical Implications Of the Translational Equilibriometrimentioning

confidence: 90%

“…As mentioned before, every single schizophrenic patient might combine prototypical schizotaxic LMPs (indicating locomotor ataxia) with atypical nonschizotaxic ones (indicating either hypolocomotion or hyperlocomotion). Evaluating such subclinical combinations of qualitative and quantitative locomotor abnormalities could allow us to make more reliable predictions for more appropriate drug therapy and its more accurate dosage, which might lead to individualized or personalized treatment strategies . On the other hand, the diversity of possible locomotor combinations could explain why the individual reactions to one and the same antipsychotic treatment might vary from patient to patient and why these individual reactions are more predictable by objective evaluation of the patient's motor abnormalities .…”

Section: Translational Implications Of the Objective Locomotor Evaluamentioning

confidence: 99%

“…12,14 itative and quantitative locomotor abnormalities could allow us to make more reliable predictions for more appropriate drug therapy and its more accurate dosage, 19,29,36,40,46,51 which might lead to individualized or personalized treatment strategies. [59][60][61][62][63][64] On the other hand, the diversity of possible locomotor combinations could explain why the individual reactions to one and the same antipsychotic treatment might vary from patient to patient and why these individual reactions are more predictable by objective evaluation of the patient's motor abnormalities. 46,[68][69][70][71][72] As we consider the schizotaxic LMPs as locomotor biomarkers for early detection of vulnerability to develop schizophrenia, such an approach links our findings with the classical neuroscience tradition of translational animal research in psychiatry.…”

Section: Clinical Implications Of the Translational Equilibriometrimentioning

confidence: 99%

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Objective and quantitative equilibriometric evaluation of individual locomotor behaviour in schizophrenia: Translational and clinical implications

Haralanov

Haralanova

Milushev

et al. 2018

Evaluation Clinical Practice

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Psychiatry is the only medical specialty that lacks clinically applicable biomarkers for objective evaluation of the existing pathology at a single-patient level. On the basis of an original translational equilibriometric method for evaluation of movement patterns, we have introduced in the everyday clinical practice of psychiatry an easy-to-perform computerized objective quantification of the individual locomotor behaviour during execution of the Unterberger stepping test. For the last 20 years, we have gradually collected a large database of more than 1000 schizophrenic patients, their relatives, and matched psychiatric, neurological, and healthy controls via cross-sectional and longitudinal investigations. Comparative analyses revealed transdiagnostic locomotor similarities among schizophrenic patients, high-risk schizotaxic individuals, and neurological patients with multiple sclerosis and cerebellar ataxia, thus suggesting common underlying brain mechanisms. In parallel, intradiagnostic dissimilarities were revealed, which allow to separate out subclinical locomotor subgroups within the diagnostic categories. Prototypical qualitative (dysmetric and ataxic) locomotor abnormalities in schizophrenic patients were differentiated from 2 atypical quantitative ones, manifested as either hypolocomotion or hyperlocomotion. Theoretical analyses suggested that these 3 subtypes of locomotor abnormalities could be conceived as objectively measurable biomarkers of 3 schizophrenic subgroups with dissimilar brain mechanisms, which require different treatment strategies. Analogies with the prominent role of locomotor measures in some well-known animal models of mental disorders advocate for a promising objective translational research in the so far over-subjective field of psychiatry. Distinctions among prototypical, atypical, and diagnostic biomarkers, as well as between neuromotor and psychomotor locomotor abnormalities, are discussed. Conclusions are drawn about the translational and clinical implications of the new approach and its future perspectives.

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Section: Clinical Implications Of the Translational Equilibriometrimentioning

confidence: 90%

Section: Translational Implications Of the Objective Locomotor Evaluamentioning

confidence: 99%

Section: Clinical Implications Of the Translational Equilibriometrimentioning

confidence: 99%

See 1 more Smart Citation

Objective and quantitative equilibriometric evaluation of individual locomotor behaviour in schizophrenia: Translational and clinical implications

Haralanov

Haralanova

Milushev

et al. 2018

Evaluation Clinical Practice

View full text Add to dashboard Cite

show abstract

“…The second plan of the project was to utilize existing Finnish biobanks in the PSYCOHORTS consortium. Combining pure biological data from biobanks with large cohort data will help identify biomedical patterns that predict diagnosis and phenotypes with high accuracy, which is the major goal of personalized medicine [50].…”

Section: Plans and Perspectives Of Psycohortsmentioning

confidence: 99%

The Finnish psychiatric birth cohort consortium (PSYCOHORTS) – content, plans and perspectives

Filatova

Gyllenberg

Sillanmäki

et al. 2019

Nordic Journal of Psychiatry

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Background: Psychiatric disorders tend to be developmental, and longitudinal settings are required to examine predictors of psychiatric phenomena. Replicating and combining data and results from different birth cohorts, which are a source of reliable data, can make research even more valuable. The Finnish Psychiatric Birth Cohort Consortium (PSYCOHORTS) project combines birth cohorts in Finland. Aim: The aim of this paper is to introduce content, plans and perspectives of the PSYCOHORTS project that brings together researchers from Finland. In addition, we illustrate an example of data harmonization using available data on causes of death. Content: PSYCOHORTS includes eight Finnish birth cohorts. The project has several plans: to harmonize different data from birth cohorts, to incorporate biobanks into psychiatric birth cohort research, to apply multigenerational perspectives, to integrate longitudinal patterns of marginalization and inequality in mental health, and to utilize data in health economics research. Data on causes of death, originally obtained from Finnish Cause of Death register, were harmonized across the six birth cohorts using SAS macro facility. Results: Harmonization of the cause of death data resulted in a total of 21,993 observations from 1965 to 2015. For example, the percentage of deaths due to suicide and the sequelae of intentional self-harm was 14% and alcohol-related diseases, including accidental poisoning by alcohol, was 13%. Conclusions: PSYCOHORTS lays the foundation for complex examinations of psychiatric disorders that is based on compatible datasets, use of biobanks and multigenerational approach to risk factors, and extensive data on marginalization and inequality.

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“…Heterogeneity in symptoms, course, and etiology of disorders is recognized as a profound challenge in studying psychopathology (Dacquino et al , 2015, Geschwind & Flint, 2015, Hines et al , 2005, Lee et al , 2016, Milaneschi et al , 2016, Wium-Andersen et al , 2017). Although this challenge makes gene identification a particularly difficult undertaking, it is hypothesized to be overcome by “brute force” approaches with large sample sizes, as described above (e.g.…”

Section: Post-gwas Areas Of Exploration From a Developmental Perspectivementioning

confidence: 99%

Post‐GWAS in Psychiatric Genetics: A Developmental Perspective on the “Other” Next Steps

Dick

Barr

Cho

et al. 2018

Genes Brain and Behavior

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As psychiatric genetics enters an era where gene identification is finally yielding robust, replicable genetic associations and polygenic risk scores, it is important to consider next steps and delineate how that knowledge will be applied to ultimately ameliorate suffering associated with substance use and psychiatric disorders. Much of the post-genome-wide association study discussion has focused on the potential of genetic information to elucidate the underlying biology and use this information for the development of more effective pharmaceutical treatments. In this review we focus on additional areas of research that should follow gene identification. By taking genetic findings into longitudinal, developmental studies, we can map the pathways by which genetic risk manifests across development, elucidating the early behavioral manifestations of risk, and studying how various environments and interventions moderate that risk across developmental stages. The delineation of risk across development will advance our understanding of mechanism, sex differences and risk and resilience processes in different racial/ethnic groups. Here, we review how the extant twin study literature can be used to guide these efforts. Together, these new lines of research will enable us to develop more informed, tailored prevention and intervention efforts.

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Personalized medicine in psychiatry

Cited by 58 publications

References 97 publications

Objective and quantitative equilibriometric evaluation of individual locomotor behaviour in schizophrenia: Translational and clinical implications

Objective and quantitative equilibriometric evaluation of individual locomotor behaviour in schizophrenia: Translational and clinical implications

The Finnish psychiatric birth cohort consortium (PSYCOHORTS) – content, plans and perspectives

Post‐GWAS in Psychiatric Genetics: A Developmental Perspective on the “Other” Next Steps

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