2017
DOI: 10.3390/jpm7040012
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Personalized Nanomedicine: A Revolution at the Nanoscale

Abstract: Nanomedicine is an interdisciplinary research field that results from the application of nanotechnology to medicine and has the potential to significantly improve some current treatments. Specifically, in the field of personalized medicine, it is expected to have a great impact in the near future due to its multiple advantages, namely its versatility to adapt a drug to a cohort of patients. In the present review, the properties and requirements of pharmaceutical dosage forms at the nanoscale, so-called nanomed… Show more

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Cited by 132 publications
(90 citation statements)
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“…Since then, nanotechnology enormously grew in a number of fields, including physics, biology, chemistry, medicine, electronics, and information technology, and it is currently part of our everyday life. The advent of nanotechnology in the medical field, giving rise to the term nanomedicine, dates back to the 1990s [11], even if several nanosystems, now applied for drug delivery, were designed and developed previously in the 1960s [12]. The term 'nanosystem' refers to a system having a size comprised between 1 and 1000 nm [11].…”
Section: Nanoparticles As Drug Delivery Systemsmentioning
confidence: 99%
See 1 more Smart Citation
“…Since then, nanotechnology enormously grew in a number of fields, including physics, biology, chemistry, medicine, electronics, and information technology, and it is currently part of our everyday life. The advent of nanotechnology in the medical field, giving rise to the term nanomedicine, dates back to the 1990s [11], even if several nanosystems, now applied for drug delivery, were designed and developed previously in the 1960s [12]. The term 'nanosystem' refers to a system having a size comprised between 1 and 1000 nm [11].…”
Section: Nanoparticles As Drug Delivery Systemsmentioning
confidence: 99%
“…The advent of nanotechnology in the medical field, giving rise to the term nanomedicine, dates back to the 1990s [11], even if several nanosystems, now applied for drug delivery, were designed and developed previously in the 1960s [12]. The term 'nanosystem' refers to a system having a size comprised between 1 and 1000 nm [11]. They are mostly designed for drug delivery (triggered or non-triggered), imaging, regenerative, and gene therapy purposes.…”
Section: Nanoparticles As Drug Delivery Systemsmentioning
confidence: 99%
“…The use of DNA nanostructures for the detection and isolation of circulating tumor cells can help the identification of the type and source tissue of the cancer [169]. Overall, DNA nanostructures are potential tools for a more comprehensive specific diagnosis and treatment [170]. Novel biomarkers, such as Oncotype DX and MammaPrint, are complementing traditional ones-estrogen and progesterone receptors, and human epidermal growth factor receptor 2 (HER2)-as efficient prevention and prognostic tools for breast cancer [171].…”
Section: Dna Nanostructures As Personalized Therapymentioning
confidence: 99%
“…Personalized medicine consists in the tailoring of either the diagnosis, treatment, or prevention of a disease based on the unique genetic profile of a patient. It results in the shift from a “one‐size‐fits‐all” approach, where all patients that are diagnosed with the same disease will receive the same treatment, to a “personalized” approach, where a specific treatment is designed for a specific patient or group of patients . Such an individualized approach aims at overcoming the limitations related to the conventional symptoms oriented diagnosis and treatment of a disease, which include i) focus on terminal symptoms, with low or no attention to risk factors; ii) broad description of a disease, without discriminating between diseases that may have similar symptoms but different pathophysiology; iii) lack of attention to the underlying mechanisms of the symptoms; and iv) use of common therapeutic targets without taking into consideration the heterogeneity and complexity of pathophysiologic determinants of specific diseases, i.e., tumor microenvironment for cancer diseases.…”
Section: Biohybrid Nps Potential In Personalized Medicinementioning
confidence: 99%